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The clinical presentation of Alzheimer's disease (AD) varies widely across individuals but the neurobiological mechanisms underlying this heterogeneity are largely unknown. Here, we compared regional gray matter (GM) volumes and associated gene expression profiles between cognitively-defined subgroups of amyloid-β positive individuals clinically diagnosed with AD dementia (age: 66 ± 7, 47% male, M

Implicit assumptions, approaches, rules and practices in teaching i.e. teaching and learning regimes (TLRs) are produced and reproduced (cf. Trowler & Cooper 2002) in the closest teaching environment, traditionally within a discipline. However, multidisciplinary programs implies that teachers from different disciplines and with different taken for granted assumptions, approaches and rules are Implicit assumptions, approaches, rules and practices in teaching i.e. teaching and learning regimes (TLRs) are produced and reproduced (cf. Trowler & Cooper 2002) in the closest teaching environment, traditionally within a discipline. However, multidisciplinary programs implies that teachers from different disciplines and with different taken for granted assumptions, approaches and rules are

Den främsta orsaken till en ökad växthuseffekt anses idag bero på en högre koncentrationav koldioxid i atmosfären. Sedan den industriella revolutionen harmänniskan påverkat mängden koldioxid i atmosfären genom aktiviteter så somförbränning av fossila bränslen, avskogning, förändringar i markanvändning, samtcementproduktion. För att kunna motverka framtida klimatförändringar krävs enfördjupad kunskThis thesis focuses on the development and application of efficient mathematicaltools for estimating and modelling the exchange of carbon dioxide (CO2) between the Earth and its atmosphere; here referred to as the global CO2 surface flux.There are two main approaches for estimating the CO2 flux: Processed based(bottom-up) modelling and atmospheric inversion (top-down) modelling. Thefirst part of t

The overall purpose of this thesis is to improve our understanding of how disaster risk management (DRM) systems function. Specifically, it aims to increase our knowledge about effective communication in a multi-stakeholder, multi-level DRM system, with a particular focus on the exchange of risk-related information for risk assessment. The Swedish DRM system is taken as a study case to examine how

Denna kunskapssammanställning beskriver hur hälsoskadlig värme kan uppstå inomhus, hur den kan identifieras och vilka åtgärder som kan vidtas med fokus på fastighetsägarens ansvar. Sammanställningen är begränsad till befintliga byggnader i Sverige och inkluderar skolor, äldreboenden, lägenheter, förskolor och kontor som är icke-industriella (utan industriella processer som producerar värme). Den pThis literature review describes how heat stress can develop indoors, how it can be identified, and what actions can be taken, with a focus on property owner’s responsibilities. The review is limited to existing buildings in Sweden and includes schools, retirement homes, apartments, preschools, and non-industrial offices (those without industrial processes that produce heat). The expected climate

IGF-1 is an essential regulator of fetal growth and brain development. Preterm birth in the human is followed by a rapid decrease in serum levels of IGF-1 and decreased levels of IGF-1 have been associated with development of severemorbidity. A recent clinical trial indicated that supplementation with IGF-1 prevented development of severe intraventricular hemorrhage (IVH) in extremely preterm infa

Context. The solar vicinity is currently populated by a mix of stars with various chemo-dynamic properties, including stars with a high metallicity compared to the Sun. Dynamical processes such as churning and blurring are expected to relocate such metal-rich stars from the inner Galaxy to the solar region. Aims. We report the identification of a set of old super-metal-rich (+0.15 ≤ [Fe/H] ≤ +0.50

Alloys and bimetallic systems have shown many advantages in heterogeneous catalysis, but the details of their catalytic functions are not always known. For instance, the atomic details about surface reconstructions under catalytic reaction conditions, or which phases that are high-active or low-active. Furthermore, the model catalysts studied in laboratories often differ a lot from the industrial

Key performance indexes (KPIs) in various forms have always been used in one way or another in the production and processing of raw materials. The need for KPIs was accentuated with the advent of industrialism in the western world. The way and strategy of manufacturing industrial products has been divided into several so-called developmental transformations. Primarily after the depression of the 1

Nowadays, there is a tendency towards higher dynamics in markets and increasing competition especially in engineering and high tech industries. Firms today need to invent new products, acquire unique business models and thereby continuously exceed customer expectations as well as outperform competition. In contrast to the previous innovative approach that relied solely on internal capabilities, ma

Title: To commit or not commit: An examination of employee commitment towards organizational CSR initiatives Course: BUSN39 Business Administration: Global Marketing Authors: Luis Ibbeken & Oliver Åkerman Key Words: Employee´s CSR commitment; employee´s CSR communication; organizational culture; internal CSR; internal communication; training & education; leadership; IKEA; home furnishi

Den organiserade brottsligheten har länge plågat samhället och dess moderna tappning kan dateras till slutet av 1800-talet. På grund av sin unika struktur har den organiserade brottsligheten visat sig vara särskilt svårutredd. Den organiserade brottsligheten fortsätter att växa i Sverige samtidigt som polis och åklagaren med tillgängliga medel försöker förhindra dess framfart och expansion. FråganOrganised crime is a type of criminal enterprise that has plagued society for ages, with its modern form dating back to the late 1800’s. Because of its unique structure considering the general sense of criminality, organised crime has proven to be an exceptionally difficult criminal activity to battle. Organised crime continues to grow in Sweden, with both the police and prosecutors trying to use

Människohandel är ett globalt fenomen som förekommer över i stort sett hela världen. Sverige är på intet sätt förskonat från denna cyniska verksamhet, utan har tvärt om visats sig utgöra en lukrativ marknad för människohandlare. Detta då det finns en efterfrågan på de tjänster som verksamheten tillhandahåller, framför allt de av sexuell karaktär. I denna framställning undersöks den svenska konstruHuman trafficking is a global phenomenon that occurs all over the world. Sweden is by no means spared from this cynical practice. On the contrary, the country has shown to be a lucrative market for traffickers. A reason for this is the major demand for the services that trafficking provides, especially those of a sexual nature. This presentation examines the legal construction of the human traffic

Uppgiftsskydd och marknadsexklusivitet är två nya immaterialrättsliga skydd till fördel för forskande läkemedelsföretag. Dessa skydd utgör komplement till bland annat patent och upphovsrätt och syftar till att skydda läkemedelsföretagens produkter från konkurrens. Uppgiftsskydd och marknadsexklusivitet har funnits i EU:s lagstiftning sedan 1987 men har först de senaste åren fått en ökad betydelse Data exclusivity and marketing exclusivity are two new forms intellectual property rights, for the benefit of pharmaceutical companies. They constitute a complement to other IPRs, including patent and copyright, and are intended to provide new pharmaceutical products with a limited time of protection against competition. Data exclusivity and marketing exclusivity has been a part of EU legislation

Sedan EU bildades har unionen haft en central roll för att integrera medlemsstaterna och har också som en effekt av detta haft ett ökande inflytande på medlemsstaternas nationella lagstiftning. Dessutom har denna utveckling lett till juridiska överväganden avseende hur EU:s författningar ska tolkas och verkställas och hur denna integration ska kunna säkerställas. Det finns fyra friheter i EU-fördr

The state of Akwa Ibom, Nigeria is known as one of the wetlands rich in biodiversity as well as oil and gas reserves. Its wetland ecosystem is noted for its primary support it has provided for the people living in this area. However, this wetland has also been a reservoir for Nigeria’s crude oil contributing a prominent share of petroleum product to the country’s GDP, total revenue to the governme

I ett samhälle där bilismen ökar blir en mer hållbar bilism allt viktigare. Sverige har satt upp som mål att ha en fossiloberoende fordonsflotta till 2030 och en helt fossilfri fordonsflotta till 2050. För att kunna uppnå detta spelar elbilen en viktig roll. Genom intervjuer med olika aktörer på den svenska marknaden visas i detta examensarbete att en stor tilltro sätts till elbilen, vid sidan av In a society with growing car mobility, sustainable motorism becomes increasingly important. Sweden has set targets of having a fossil fuel independent vehicle fleet by 2030 and a fossil free vehicle fleet by 2050.In order to reach these targets the electric car plays an important role. Through interviews with different actors on the Swedish market, this thesis shows that much confidence is put in

Three-dimensional (3D) models are widely used within the geosciences to provide scientists with conceptual and quantitative models of the earth’s subsurface. As a result, 3D geologic modelling is a growing field, such that scientific research often cannot keep up with technical advancements. Literature often shows conflicting results with respect to which interpolation algorithms produce the best

The interaction of a solid target with an ultra-high intensity laser pulse can result in the laser plasma acceleration of ions. The recent proposal of a new laser plasma ion acceleration scheme, named chirped standing wave acceleration, has created interest in a new class of ultra-thin solid target materials, either freestanding or as a part of novel compound targets. In this thesis, it is assesse