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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 114809 hits

Localization of phosphatidylserine binding sites to structural domains of factor X-a

Binding of short chain phosphatidylserine (C6PS) enhances the proteolytic activity of factor X-a by 60-fold (Koppaka, V., Wang, J., Banerjee, M., and Lentz, B. R. (1996) Biochemistry 35, 7482-7491). In the present study, we locate three C6PS binding sites to different domains of factor X-a using a combination of activity, circular dichroism, fluorescence, and equilibrium dialysis measurements on p

Low-intensity family therapy intervention is useful in a clinical setting to treat obese and extremely obese children

Aims. To study the influence of low-intensity solution-focused family therapy with obese and extremely obese pediatric subjects on body mass index (BMI) z-scores and self-esteem. Materials and Methods. Fifty-four obese children, aged 6-17 years, were referred to an outpatient obesity clinic. The families received solution-focused family therapy provided by a multidisciplinary team. Height and weig

Technique for measuring moisture storage capacity at high moisture levels

Knowledge of moisture storage capacity above the hygroscopic range is essential when calculating moisture, especially when different materials are to be connected. Generally, the storage capacity is represented by water retention curves, in which suction is plotted against the moisture content. In a number of laboratories in Europe and North America, the pressure plate and pressure membrane techni

Core excitation in O-3 localized to one of two symmetry-equivalent chemical bonds: Molecular alignment through vibronic coupling

Core excitation from terminal oxygen O-T in O-3 is shown to be an excitation from a localized core orbital to a localized valence orbital. The valence orbital is localized to one of the two equivalent chemical bonds. We experimentally demonstrate this with the Auger-Doppler effect which is observable when O-3 is core excited to the highly dissociative O(T)1S(-)17a(1)(1) state. Auger electrons emit

Age and sex are important factors in determining normal retinol levels

Cut-off levels for serum retinol levels of 20 micrograms/dl for marginal and 10 micrograms/dl for definite deficiency have been advocated and extensively used in population studies. However, the blood serum levels of retinol of the newborn are known to be very low and although the age dependency of the retinol binding protein has been described, the normal levels of serum retinol at different ages

Colour development in copper ruby alkali silicate glasses. Part 1. The impact of tin(II) oxide, time and temperature

The development of the red colour in copper ruby alkali silicate glasses has been studied by means of ultraviolet/visible spectroscopy, TEM and EXAFS. The results show that in both red and slightly overstruck, brownish glasses the colour is due to clusters of metallic copper. Before striking non-coloured glasses contain mainly cuprous ions, Cu+. Tin acts as a reducing agent but also has an acceler

New halogen-specific detector applied to the analysis of chlorinated fatty acids

A new halogen-specific detection method (XSD) was tested for determination of chlorinated fatty acids in marine biota. In XSD, an increased emission of ions and electrons is caused by the high-temperature combustion of halogen-containing compounds. The detection limit of methyl dichlorooctadecanoate and the selectivity at a reactor temperature of 900 degreesC match those of electrolytic conductivi

Intrauterine or oral administration of levonorgestrel in combination with estradiol to perimenopausal women--effects on lipid metabolism during 12 months of treatment

OBJECTIVE: Limited data concerning serum lipids and lipoproteins are available on the effect of HRT in perimenopausal women, who commonly have marked bleeding disturbances and may have severe climacteric symptoms. Almost all previously published data have utilized a simplified form of lipoprotein analysis, which includes an estimation and not a determination of LDL cholesterol. To delineate the ro

Altered vascular responses in experimental congestive heart failure

Popular Abstract in Swedish Hjärtsvikt är ett sjukdomstillstånd som blir allt vanligare i vårt samhälle i takt med att människor blir äldre och att man idag räddar allt fler människor till livet efter hjärtinfarkt. Som namnet antyder sviktar hjärtat, det kan inte pumpa ut den mängd blod som krävs för att tillgodose kroppens behov av syre och näringsämnen. Sjukdomen indelas i olika svårighetsgraderCongestive heart failure is accompanied with increased circulatory levels of several vasoregulatory neurotransmitters and hormones which affect the outcome of this disease. In this thesis the blood levels of several vasoactive peptides in humans with congestive heart failure and their effects on the vasculature by the use of an animal model of heart failure were studied. Patients with congestive

Conceptions, Categories, and Embodiment: Why Metaphors are of Fundamental Importance for Understanding Norms

The propositions in this chapter are to a large extent drawn from the thesis Metaphors and norms – understanding copyright law in a digital society (Larsson 2011b), however with some important complements, not least concerning the implications of categorisation. The chapter is explorative in bringing findings from cognitive linguistics into the quite common socio-legal task of studying norms. Its

eavesROP: Listening for ROP Payloads in Data Streams

We consider the problem of detecting exploits based on return-oriented programming. In contrast to previous works we investigate to which extent we can detect ROP payloads by only analysing streaming data, i.e., we do not assume any modifications to the target machine, its kernel or its libraries. Neither do we attempt to execute any potentially malicious code in order to determine if it is an att

Prosody in Swedish Children with Language Impairment. Perceptual, Acoustic and Interactional Aspects

Popular Abstract in Swedish Prosodi definieras som talets rytmiska, dynamiska och melodiska egenskaper (Bruce, 1998). Till de prosodiska dragen hör längd (kvantitet), betoning (tryck- och ordaccent), ton, satsmelodi (intonation) och gränser (tomrum i talvågen). Dessa drag används i kommunikativt syfte för att särskilja betydelser hos ord och orddelar, för att framhäva och gruppera delar av talet oThe aim of this thesis was to explore prosodic problems in Swedish children with language impairment (LI). In the first study, 29 children with LI participated. They were assessed with an assessment procedure for prosody at the word, phrase and discourse levels, developed within this thesis. The results showed that 41% of the children had prosodic problems to some extent. In addition, reliability

Multi-Pitch Estimation using Harmonic MUSIC

In this paper, we present a method for estimation of the fundamental frequencies, or pitches, of several periodic sources. This difficult estimation problem occurs, for example, in speech and audio processing whenever multiple speakers or tones are present. The presented method is an extension of a recently proposed method for estimation of the fundamental frequency of a set of harmonically relate