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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193297 hits

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This study evaluates the spatial and temporal performance of the Climate Hazard Group InfraRed Precipitation Satellite (CHIRPS) against Tropical Rainfall Measuring Mission (TRMM) Multi-Satellite Precipitation Analysis (TMPA) 3B42/3B43 v. 7 and Global Precipitation Measurement (GPM)-based Integrated Multi-Satellite Retrievals for GPM (IMERG V06), from 2000 to 2013. Several statistical metrics were

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Sjögren’s syndrome (SS) is an exocrinopathy characterized by the hypofunction of salivary glands (SGs). Aquaporin-5 (AQP5); a water channel involved in saliva formation; is aberrantly dis-tributed in SS SG acini and contributes to glandular dysfunction. We aimed to investigate the role of ezrin in AQP5 mislocalization in SS SGs. The AQP5–ezrin interaction was assessed by immuno-precipitation and p

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OBJECTIVE Diabetic nephropathy is a serious complication of type 1 diabetes. Recent studies indicate that end-stage renal disease (ESRD) incidence has decreased or that the onset of ESRD has been postponed; therefore, we wanted to analyze the incidence and time trends of ESRD in Sweden. RESEARCH DESIGN AND METHODS In this study, patients with duration of type 1 diabetes >14 years and age at onset

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The aim of this study was to estimate familial risks of Parkinson's disease (PD) in first-degree relatives of probands with PD compared with first-degree relatives of control probands. Standardized incidence ratios (SIRs) of PD were estimated in the total Swedish population for the period January 1, 1987 to December 31, 2001. SIRs were calculated by age, sex, occupation, geographic region, family

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Technological development, in particular the development of information and communicatiion technologies (ICT), is often presented as the answer to many social problems. Proponents of the Information Society suggest that poverty, failing integration, unemployment, and llack of democracy can be addressed with the appropriate technological means. Inequality iis often framed in terms of a digital divi

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Background: Studies assessing institutional performance regarding quality of care are frequently performed using single-level statistical analyses investigating differences between provider averages of various quality indicators. However, such analyses are insufficient as they do not consider patients' heterogeneity around those averages. Hence, we apply a multilevel analysis of individual-patient

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Energy efficiency measures in residential buildings typically include changes in ventilation and heating systems, and increased thermal insulation of the building envelope. The expected energy efficiency is not always reached, despite large knowledge and professional implementation of each separate measure. Thereis a lack in understanding of how technical systems interact, and how the ocupants are

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Aims: To investigate the trends in nutritional compliance of recipes from a Swedish food magazine to offer a perspective on the effects of home cooking on public health. Methods: The nutritional content of 654 recipes from magazine issues published in 1970, 1980, 2000, and 2010 were collected. The recipes were analyzed for macronutrient energy contribution, sodium content, and composition. Results

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The international community has been engaged in capacity development for decades, sometimes under different names or with a slightly different focus. So far, these efforts have failed to bring significant and sustainable change. The Sendai Framework for Disaster Risk Reduction 2015–2030 specifies capacity development as the means to reduce disaster losses substantially. The purpose of this paper i

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On-site cellulase enzyme fermentation in a softwood-to-ethanol process, based on S -catalysed steam pretreatment followed by simultaneous saccharification and fermentation, was investigated from a techno-economic aspect using Aspen Plus and Aspen Icarus Process Evaluator softwares. The effect of varying the carbon source of enzyme fermentation, at constant protein and mycelium yields, was monitore

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Nutrient iron sequestration is the most significant form of nutritional immunity and causes bacterial pathogens to evolve strategies of host iron scavenging. Cigarette smoking contains iron particulates altering lung and systemic iron homeostasis, which may enhance colonization in the lungs of patients suffering chronic obstructive pulmonary disease (COPD) by opportunistic pathogens such as nontyp

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Objective: To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice. Methods: We performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibros

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Excerpt: "Just like the rest of the population, Swedish Christians remain fundamentally divided in their opinions about the best way to arrange Sweden’s relationship to NATO. But the responses on the part of the churches also seem to hark back to bygone ages. National defense and foreign policy remain, in a country for centuries fundamentally shaped by Lutheran doctrine concerning the division bet

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This paper presents the numerical results of combustion and soot recession in the Engine Combustion Network (ECN) Spray A and D flames using large eddy simulations (LES). The nominal injector nozzle diameters for the ECN Spray A and D are 90μm and 186μm. A two-equation soot model is implemented to model the soot formation and oxidation processes. The numerical model is validated by comparing the s

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Introduction: Distal radius fractures (DRF) are associated with increased risk of subsequent fractures and physical decline in older adults. This study aims to evaluate the risk cognitive decline following DRF and potential for timely screening and intervention. Methods: A cohort of 1046 individuals 50–75 years of age with DRF were identified between 1995 and 2015 (81.5% female; mean age 62.5 [± 7

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BACKGROUND: Group B Streptococcus (GBS) transmission during pregnancy causes preterm labor, stillbirths, fetal injury, or neonatal infections. Rates of adult infections are also rising. The GBS-NN vaccine, engineered by fusing N-terminal domains of GBS Alpha C and Rib proteins, is safe in healthy, nonpregnant women, but further assessment is needed for use during pregnancy. Here, we tested GBS-NN

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BACKGROUND: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes. Atherosclerosis has been suggested as one of the underlying mechanisms, and findings from experimental studies support this, but human data are scarce. OBJECTIVES: Our objective was to determine the association between environmental lead exposure based on blood lead (B-Pb) concentrat