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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 192180 hits

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European settler colonies are often thought to have been characterized by a continued expansion of the landed frontier, which impacted the distribution of wealth across their settler populations. Hampered by a lack of data, few studies have been able to study this in-depth. How does settlement timing affect wealth and wealth accumulation when frontier expansion is not a smooth continuous process?

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Oral direct inhibitors (ODIs) of thrombin and factor Xa are now approved as anticoagulant drugs. The first two drugs to complete phase III clinical trials for thromboprophylaxis in orthopaedic surgery and treatment of patients with atrial fibrillation or venous thromboembolism were dabigatran and rivaroxaban. These small molecules are given at fixed dose with no requirement for monitoring as pharm

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Although the associations between climate, food conditions and reproduction in the wild has been the focus of numerous studies in recent years, we still know little about population level responses to climate and fluctuating food conditions in long-lived species and during longer periods of time. Here, we assessed the relative importance of the abundance of the main prey in winter (small mammals),

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Background: Postoperative pain clinical management in neonates has always been a challenging medical issue. Worldwide, several systemic opioid regimens are available for pediatricians, neonatologists, and general practitioners to control pain in neonates undergoing surgical procedures. However, the most effective and safe regimen is still unknown in the current body of literature. Objectives: To d

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This article presents several sport clubs in Finland connected to an organization Idrottsförening Kamraterna (Sporting Society Comrades), also known as IFK that originated in Sweden in 1895. The idea of IFK clubs reached Finland in 1897 and spread throughout the country. The beginning of the twentieth century was a period of growth and expansion for IFK, both in Sweden and Finland. IFK clubs forme

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Study design: Cross-sectional study. Objectives: To identify socio-demographic and injury-related factors that contribute to activity limitations and participation restrictions in people with spinal cord injury (SCI) in Bangladesh. Setting: Centre for the Rehabilitation of the Paralysed (CRP), Savar, Dhaka, Bangladesh. Methods: This study involved 120 (83% men) participants with SCI; their median

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In Sweden, approximately 1,200 individuals die by suicide annually. Inpatient suicide is considered rare, but death by suicide still occurs when admitted to a psychiatric hospital. This study was part of a national retrospective project covering data from all patients' medical records for the 2 years before death by suicide in 2015. In this study, 41 patients who died by suicide while being admitt

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This study regards a Child Play-and-Learn Area (CPLA) in a library as a third place and investigates its relationships with visitors through the concept of place attachment. To understand the influence of the CPLA, the study examined the relationships among visitors' place attachment, servicescape and behavioural intentions involving place scales. A survey was conducted in a CPLA in Christchurch,

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Today's Carrier-Envelope Phase (CEP) stabilizations of mode-locked oscillators widely used in attosecond science and frequency metrology rely on octave spanning frequency combs and the detection of beating between the blue end and the frequency doubled red end of the same spectrum. This technique was established by the seminal works of Hänsch and co-workers [1], demonstrating the stabilization of

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Background: TDP-43 proteinopathies represent a spectrum of neurological disorders, anchored clinically on either end by amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). The ALS–FTD spectrum exhibits a diverse range of clinical presentations with overlapping phenotypes, highlighting its heterogeneity. This study was aimed to use disease progression modeling to identify nov

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The popularity of digital gaming among older adults is on the rise, necessitating a deeper understanding of this phenomenon. Drawing upon the concepts and theoretical perspectives in domestication theory, actor network theory, and media engagement theory, we explored the digital gameplay experiences of older adults in China’s sociocultural contexts. We conducted in-depth interviews with 12 adults

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This article assesses the tension between cosmopolitan and communitarian approaches to the ethics of migration by analysing how the Protestant Church in Germany (EKD) has responded to the current so-called migration crisis in Europe. I argue that the statements of the EKD frame people on the move either as migrants or as Muslims. These frames come with competing ethical consequences. Whereas migra

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We report the first high-resolution, detailed abundances of 21 elements for giants in the Galactic bulge/bar within 1° of the Galactic plane, where high extinction has rendered such studies challenging. Our high-signal-to-noise-ratio and high-resolution, near-infrared spectra of seven M giants in the inner bulge, located at (l, b) = (0°, +1°), are observed using the IGRINS spectrograph. We report

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Family reunification is, in the words of the European Union (EU) Family Reunification Directive (2003/86/EC), a ‘necessary way of making family life possible’ and preserving family unity. Yet, barriers exist which hinder refugees’ realisation of their right to family reunification. By taking the plight of Eritrean refugees in Europe as a pertinent case study, this paper shows the obstacles that “p

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Alkylation of NAD+ with iodoacetic acid followed by alkaline rearrangement gave N6-carboxymethyl-NAD+. Condensation of this analogue with 1,6-diaminohexane gave the analogue NAD+- N6-[N-(6-aminohexyl)-acetamide]. The coenzymic activity of the two derivatives was tested with malate dehydrogenase, alcohol dehydrogenase and lactate dehydrogenase. The efficiency relative to unsubstitut

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The effects of transdermally administered scopolamine (TTS-scopolamine, release rate 5 g/h) and dimenhydrinate (100 pmg) were examined on caloriC., angular acceleration induced and optokinetic nystagmus in 16 volunteers in a randomized doubleblind study. All drugs induced a statistically significant decrease in maximum velocity of caloric nystagmus. In the rotatory test, two TTS-scopolamine and di

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PurposeAs the warehouse is increasingly viewed as a strategic component, retailers’ willingness to invest in automated warehouse systems (AWS) has increased. These investment decisions are influenced by well-known operational factors, but strategic factors, which have received limited attention in warehousing literature, also play a pivotal role. Addressing this gap, this study investigates how st

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The present invention provides a method for optimizing elastic flows in a multi-path network for a traffic demand by jointly determining a bandwidth for each flow in a set of flows that realize the traffic demand and an optimized path for the traffic demand by maximizing a fairness utility. The present invention can be implemented as a computer program embodied on a computer readable medium in whi