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Epithelial ovarian carcinoma has in general a poor prognosis since the vast majority of tumors are genomically unstable and clinically highly aggressive. This results in rapid progression of malignancy potential while still asymptomatic and thus in late diagnosis. It is therefore of critical importance to develop methods to diagnose epithelial ovarian carcinoma at its earliest developmental stage,

It has previously been shown that patients with haemophilia A may develop non-neutralizing anti-factor VIII (FVIII) antibodies (NNA) that escape detection by the Bethesda assay, but are detected using immune-based assays. We and others found NNAs to be directed not only towards non-functional parts of the protein, but towards all regions of the FVIII protein. We also showed a heterogeneous antibod

Bone mineral density (BMD) and geometric bone measures are individually associated with prevalent osteoporotic fractures. Whether an aggregate of these measures would better associate with fractures has not been examined. We examined relationships between self-reported fractures and selected bone measures acquired by quantitative computerized tomography (QCT), a composite bone score, and QCT-acqui

Fishing activity has been suggested to affect food web structure and functioning of aquatic ecosystems. Based on changes of the mean trophic level index of fishery catch, the present study demonstrates long-term ecosystem impacts of fisheries in Lake Chaohu, a freshwater lake in Anhui Province, China. The decline of mean trophic level (MTL) in the last five decades, coupled with a dramatic increas

Immunoecology deals with the questions about how immune defences have evolved and are being used and optimized in different environments, ecological settings and lineages. In such research, often only single time point measures and small sample volumes are available, which limits the applicability of traditional immunological methods. Methodological progress in the field thus largely depends on th

In this study, a large, farm-based, co-digestion plant in southern Sweden, using manure and various food industry wastes is investigated concerning its use of energy and its emissions of greenhouse gases from a life cycle perspective based on measured, site-specific data. The biogas is upgraded and utilized as a vehicle fuel, distributed via the natural gas grid. The case-study also includes a nov

Result: for Pb extraction experiments from a contaminated soil performed with citric acid and ethylenediaminetetraacetic acid disodium salt (Na(2)EDTA) indicate that Na(2)EDTA is much more efficient. The Pb removal after 5 successive extractions using 24 mL of 0.1 M Na(2)EDTA solutions and 8 g of soil is close to 100%. Other non-toxic metals such as Ca and Mg, that are present in important concent

We investigated the distribution, storage and landscape partitioning of soil amorphous silica (ASi) in a central Canadian region dominated by tundra and peatlands to provide a first estimate of the amount of ASi stored in Arctic permafrost ecosystems. We hypothesize that, similar to soil organic matter, Arctic soils store large amounts of ASi which may be affected by projected climate changes and

Background Several new therapeutic options for psoriasis have been tested in clinical trials in recent years. Choice of comparator, study duration and outcome measures are critical for interpreting application of trial results to clinical practice. Objectives We examined whether these trial aspects have changed substantially in recent years in comparison with the past. Methods A systematic search

We performed a candidate gene association study in 540 patients with primary Sjogren's Syndrome (SS) from Sweden (n = 344) and Norway (n = 196) and 532 controls (n = 319 Swedish, n = 213 Norwegian). A total of 1139 single-nucleotide polymorphisms (SNPs) in 84 genes were analyzed. In the meta-analysis of the Swedish and Norwegian cohorts, we found high signals for association between primary SS and

Apicidin is a potent histone deacetylase inhibitor (HDACI) that selectively binds to histone deacetylases (HDACs) class I and interferes with the deacetylation process, which results in modification of acetylation level of cellular proteins. The aim of the study was to investigate the potential time and dose dependent cytotoxicity of the test compound, Apicidin, in pancreatic cancer cells Capan-1

The aim of this study was to investigate the groundwater chemistry with special concern to metal pollution in selected communities in the Wassa West district, Ghana. In this mining area, 40 ground water samples, mainly from drilled wells, were collected. The groundwaters have generally from neutral to acidic pH values and their Eh values indicate oxidising conditions. The dominating ions are calci

The articular cartilage of synovial joints ensures friction-free mobility and attenuates mechanical impact on the joint during movement. These functions are mediated by the complex network of extracellular molecules characteristic for articular cartilage. Zonal differences in the extracellular matrix (ECM) are well recognized. However, knowledge about the precise molecular composition in the diffe

Objective: The authors sought to clarify the sources of parent-offspring resemblance for drug abuse, alcohol use disorders, and criminal behavior, using a novel genetic-epidemiological design. Method: Using national registries, the authors identified rates of drug abuse, alcohol use disorders, and criminal behavior in 41,360 Swedish individuals born between 1960 and 1990 and raised in triparental

Genetic colour polymorphisms are widespread across animals and often subjected to complex selection regimes. Traditionally, colour morphs were used as simple visual markers to measure allele frequency changes in nature, selection, population divergence and speciation. With advances in sequencing technology and analysis methods, several model systems are emerging where the molecular targets of sele

Survival after non-Hodgkin lymphoma (NHL) has increased thanks to improved treatment but NHL survivors have an increased risk of second neoplasms. The assessment of cancer risk patterns after NHL may help to quantify the late side-effects of therapy. Poisson regression was used to estimate relative risks (RRs) and absolute incidence rates for nine solid tumours based on a nationwide cohort of 60 9

Bacteria play a central role in the cycling of carbon, yet our understanding of the relationship between the taxonomic composition and the degradation of dissolved organic matter (DOM) is still poor. In this experimental study, we were able to demonstrate a direct link between community composition and ecosystem functioning in that differently structured aquatic bacterial communities differed in t

Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with o

The motivation of this study is the general lack of knowledge regarding the efficiency and the appropriate use of the adaptation strengths of Siemens automatic exposure control system CARE Dose 4D. The purpose was to evaluate the effect on radiation absorbed dose using different adaptation strengths of CARE Dose 4D in three routine pediatric CT protocols. A pediatric anthropomorphic whole body pha