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The presence of polyamines in living cells is crucial for survival. Due to their high net charge at physiological pH, polyamines effectively charge neutralize the phosphodiester backbone of DNA in an interaction that also may protect the DNA from external damage. We here present a study illustrating the influence of spermidine and spermine on the platination reactions of the model oligonucleotides

Context: T-3 action in neurons is essential for brain development. Recent evidence indicates that monocarboxylate transporter 8 (MCT8) is important for neuronal T-3 uptake. Hemizygous mutations have been identified in the X-linked MCT8 gene in boys with severe psychomotor retardation and elevated serum T-3 levels. Objective: The objective of this study was to determine the functional consequences

Popular Abstract in Swedish Fetma räknas som ett av världens tio viktigaste hälsoproblem enligt WHO och ökar i snabb takt. Man beräknar att över 1 miljard av världens vuxna befolkning är överviktig, d.v.s. har ett kroppsmasseindex (BMI) ?25.0 kg/m², varav 300 miljoner är feta, d.v.s. har ett BMI ?30.0 kg/m². I Sverige är 38% av kvinnor och 58% av män mellan 25 och 64 år överviktiga, och 11% respekThe aim of this thesis was to study the morbidity and mortality of cardiovascular disease (CVD) in obese individuals, as measured by different obesity measurements, and to explore how the CVD risk related to obesity was modified by other biologic and socio-demographic circumstances. Data from two population-based cohort studies was used. The Malmö Preventive Project included 22 444 middle-aged me

Neutron deficient nuclei near Sn-100 have been produced by fragmentation of a 1 (.) A GeV Sn-112 beam. The fragments were separated, identified and stopped in a highly segmented silicon strip detector stack. This detector measured the total energy of emitted beta(+)-particles. gamma-radiation was measured with surrounding detectors. The half-lives for many nuclides have been determined for the fir

ydrophobically modified polymers (HM-P) typically behave as thickeners in a wide range of systems. The thickening effect in an aqueous solution of this kind of polymer depends on intermolecular hydrophobic associations and also on chain entanglements if the polymer concentration is significantly above the overlap concentration. In the present investigation a rather short end-capped polymer has bee

The sensitivity of the rat submaxillary gland was examined 3-4 weeks after either parasympathetic decentralization or sympathetic decentralization or denervation. The threshold doses for secretion of saliva of parasympathomimetic (methacholine) and sympathomimetic (noradrenaline, adrenaline, phenylephrine and isoprenaline) drugs were estimated and the amount of saliva secreted in response to supra

A systematic assessment of radiotherapy for cancer was conducted by The Swedish Council on Technology Assessment in Health Care (SBU) in 2001. The assessment included an overview of the capacity for radiotherapy in terms of infrastructure of cancer care and an estimation of the costs of radiotherapy in Sweden. A postal questionnaire distributed to all 16 centres of radiotherapy in Sweden showed th

For the period 1420-1960 we contrasted fire events reconstructed at 14 sites distributed over a 50 km x 50 km area in the central part of the Komi Republic (European Russia) with a set of tree-ring width chronologies of Scots pine (Pinus sylvestris L.), developed for the same area. Our aim was to infer common climatic information contained in treering variables and independently dated fire events

In this article we report Si 2p core-level spectroscopy results from the alkali (Li, Na, and K) induced Si(111)-3 x 1 reconstructions. The experimental results are compared to the theoretical honeycomb-chain channel (HCC) model for,the 3 x 1 reconstruction using density functional theory (DFT) to calculate core-level shifts using both initial and final-state calculation schemes. Si 2p core-level s

Object: The abdominal aorta (AA) has a predilection for aneurysm formation. An etiologic factor may be underlying aortic wall stress. The purpose of this study was to examine whether the intima-media thickness (IMT) of the AA, as a surrogate to arterial wall thickness, can be measured noninvasively with satisfactory results to calculate circumferential wall stress, and to evaluate regional and gen

Popular Abstract in Swedish Sedimentära bergarter såsom t.ex. sandstenar och lerskiffrar, bildas genom att lösa sediment (t.ex. sand och lera) ”bakas” hårda när de sjunker ned i jordskorpan. Anledningen till att många lagerföljder rör sig nedåt i jordskorpan beror till viss del på de ovanliggande sedimentens tyngd, men är i huvudsak ett resultat av de platt-tektoniska rörelser som hela tiden påverPost-depositional thermal conditions have been investigated throughout the Phanerozoic sedimentary succession in Skåne. Clay mineralogy and illite crystallinity have been the main tools for the Lower Palaeozoic strata. Within the Mesozoic sequence thermal influence was examined using RockEval pyrolysis and vitrinite reflectance analysis. Clay mineralogy of the Lower Palaeozoic shales and mudstone

We determined the frequency of extra-pair paternity and intraspecific brood parasitism in European Starlings (Sturnus vulgaris) by performing multilocus DNA fingerprinting on 22 complete families from a population in southern Sweden. Among 92 nestlings, we did not detect any successful intraspecific brood parasitism. This confirms observational data that successful intraspecific brood parasitism i

Chemically skinned guinea pig taenia coli fibre bundles showed a concentration-dependent decrease in width when incubated in media containing Dextran T500 (0-0.2 g ml-1). The maximal reduction in width, observed at 0.2 g ml-1 dextran, was 32%. The effect was reversible upon removal of dextran. Isometric force was slightly increased (about 10%) at the lowest dextran concentration (0.025 g ml-1) but

Since the cloning in 1990 of cDNA corresponding to mRNA transcribed at the blood group ABO locus, polymorphisms at the ABO locus and phenotype-genotype correlation have been analysed by several investigators. An enhancer-active minisatellite motif reported to contain four 43-bp repeats has been analysed by PCR in blood samples from 160 random Swedish blood donors. Different sizes of the DNA fragme

Knowledge of feeding rates is the basis to understand interaction strength and subsequently the stability of ecosystems and biodiversity. Feeding rates, as all biological rates, depend on consumer and resource body masses and environmental temperature. Despite five decades of research on functional responses as quantitative models of feeding rates, a unifying framework of how they scale with body

The Late Ordovician is a period of major global environmental changes. Its understanding requires an integrated stratigraphical approach. Here, chitinozoan assemblages are described from the Borenshult-1 drillcore from Motala (Sweden) and related to stable carbon isotope event stratigraphy. Fifty-six rock samples, corresponding to a stratigraphic interval ranging from the upper Sandbian to Llandov

The Lymphedema Quality of Life Inventory (LQOLI) is an instrument developed for patients with different types of lymphedema. It contains physical, emotional, social, and practical dimensions and consists of 58 items, each with three sub items concerning life quality, daily life changes, and difficulties of changing and two items concerning life quality in general and in relation to lymphedema. The

The cinnamyl phenylpropyl fragrance ingredients are a diverse group of chemical structures that have similar metabolic and toxicity profiles. A toxicological and dermatological review of these fragrance ingredients is presented. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. For high end users, calculated maxim

This paper provides an ex-post assessment of the climate and energy policy developments in Chile emerging from a neoliberal economic model, during the period 1971-2007. First, correlation and regression analyses were performed to analyse historical CO2 emissions as a product of demographic, economic and energy-wide drivers. Then I estimate indicators related to CO2 emissions, energy use and econom

Background: Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA binding motif protein 3 (RBM3) has been shown to correlate with tumour progressi