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Background: Von Willebrand disease (VWD) is an inherited bleeding disorder caused by deficient or dysfunctional von Willebrand factor (VWF). VWF replacement therapy is indicated in VWD management. Methods: This systematic review was conducted to evaluate all available evidence of the efficacy, safety, dosing and consumption of pasteurized plasma-derived human coagulation FVIII/human VWF (pdVWF/FVI

Future climate scenarios are predicting considerable threats to sustainable maize production in arid and semi-arid regions. These adverse impacts can be minimized by adopting modern agricultural tools to assess and develop successful adaptation practices. A multi-model approach (climate and crop) was used to assess the impacts and uncertainties of climate change on maize crop. An extensive field s

BACKGROUND: Despite improvements in short-term survival for Out-of-Hospital Cardiac Arrest (OHCA) in the past two decades, long-term survival is still not well studied. Furthermore, the contribution of different variables on long-term survival have not been fully investigated.AIM: Examine the 1-year prognosis of patients discharged from hospital after an OHCA. Furthermore, identify factors predict

Climate change and land-use change represent a dual threat to terrestrial ecosystem functioning. In the tropics, forest conversion to agriculture is occurring alongside warming and more pronounced periods of drought. Rainfall after drought induces enormous dynamics in microbial growth (potential soil carbon storage) and respiration (determining carbon loss), affecting the ecosystem carbon budget.

Background: Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders. Objectives: We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods:

Aim: To describe healthcare utilization patterns among older people with intellectual disabilities in comparison to that of their age peers in the general population, including possible changes due to the COVID-19 pandemic. Subjects and methods: This was a Swedish longitudinal, register-based cohort study comprising 766 people aged 65+ years with intellectual disabilities (ID cohort) and 257 285 s

BACKGROUND: The Apnea-Hypopnea Index (AHI), the standard measure of obstructive sleep apnea (OSA), has limitations in reflecting disease severity.RESEARCH QUESTION: Is high hypoxic burden (HB) more strongly associated with major cardiovascular and cerebrovascular adverse events (MACCEs) than AHI≥ 30/h?STUDY DESIGN AND METHODS: This secondary analysis of the RICCADSA observational cohort included 3

Objectives: To investigate the risk of upper urinary tract urothelial carcinoma (UTUC) in patients with non-muscle-invasive bladder cancer (NMIBC), in relation to the primary NMIBC tumour risk categories, calendar time trends and intravesical Bacillus Calmette-Guerin (BCG) treatment. Patient and methods: All patients with primary NMIBC diagnosed 1997–2019 registered in Bladder Cancer Data base Swe

Accurate assessments of symptoms and illnesses are essential for health research and clinical practice but face many challenges. The absence of a single error-free measure is currently addressed by assessment methods involving experts reviewing several sources of information to achieve a best-estimate assessment. This assessment method is called the Expert Panel method in medicine, and the Best-Es

The COVID-19 crisis noted many reports of dramatic price increases of essential items such as face masks, hand sanitisers and disinfectants. Already in March 2020 the Competition Authorities in Europe, by way of a joint statement by European Competition Network and individual public announcements, cautioned against price gouging practices and re-affirmed their commitment to pursue such practices v

HPV testing has a higher sensitivity than cytology for identification of women at risk of cancer. Primary HPV testing was introduced in the organized screening program in Skåne, Sweden in 2017 for women 30 years and older. High-risk HPV E6/E7 mRNA was detected in 7.0% of these women. Primary HPV-screening identified a similar proportion of abnormal cytology (ASCUS+) as cytology-based screening (3.

BackgroundUnderstanding the heterogeneity of opioid overdose fatalities is critical to developing effective preventive interventions. This study examines patterns of care contacts among people who subsequently died from opioid overdose. The aim was to identify distinct groups of deceased individuals, based on their contacts with different care agencies in their last year of life.MethodsA retrospec

Objectives Collimators have a significant role in image quality and detectability in single-photon emission computed tomography (SPECT) imaging. Using an appropriate alloy that effectively absorbs scattered photons, without induced secondary x-rays, and with proper rigidity and weight may provide an effective approach to the image improvement that conventionally collimators made of lead (Pb). Mate

PURPOSE: The aim of this study was to set up reliable and reproducible culture conditions for 3D tumoroids derived from non-small cell lung cancer (NSCLC) cell lines to enable greater opportunity for successful cultivation of patient-derived samples.METHODS: Four NSCLC cell lines, two adenocarcinomas (A549, NCI-H1975) and two squamous cell carcinomas (HCC-95, HCC-1588), were first cultured in trad

Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory joint disease that affects all aspects of life. Rheumatology care strives to achieve optimal health based on person-centred care (PCC). Effective treatment is available, but patients still experience unmet needs.Aims: The overall aim of this thesis was to explore patients' perspectives of PCC and preferred outcomes in early RA. Specifi

BackgroundNoncommunicable disease, in particular cardiovascular disease (CVD) and diabetes are a major cause of morbidity and mortality in the world. Short and long sleep durations are associated with adverse health outcomes, however, the biological mechanisms for these associations are not fully elucidated. The aim of this thesis is to investigate the association between sleep duration and proteo

Purpose: To demonstrate the technical feasibility and the value of ultrahigh-performance gradient in imaging the prostate in a 3T MRI system. Methods: In this local institutional review board–approved study, prostate MRI was performed on 4 healthy men. Each subject was scanned in a prototype 3T MRI system with a 42-cm inner-diameter gradient coil that achieves a maximum gradient amplitude of 200 m

Background and purpose: Stereotactic body radiotherapy (SBRT) has emerged as a promising treatment for patients with ventricular tachycardia (VT) who do not respond to standard treatments. However, the management of respiratory motion during treatment remains a challenge. This study aimed to investigate the effect of abdominal compression (AC) on respiratory induced motion in the heart. Materials