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Evidence suggests that educational differences in perinatal outcomes have increased in some countries (Eastern Europe) while remained stable in others (Scandinavian countries). However, less is known about the experience of Southern Europe. This study aims to evaluate the association between maternal education and perinatal outcomes derived from birthweight (low birthweight and macrosomia) and ges

The amyloid cascade hypothesis on the pathogenesis of Alzheimer's disease (AD) states that amyloid beta (A beta) accumulation in the brain is a key factor that initiates the neurodegenerative process. A beta is generated from amyloid precursor protein (APP) through sequential cleavages by BACE1 (the major beta-secretase in the brain) and gamma-secretase. The purpose of this study was to characteri

PURPOSE. Alzheimer disease (AD) and age-related ocular diseases are characterized by inflammation and accumulation of insoluble proteins. We aimed to investigate the detectability and clinical relevance of a panel of AD-related markers, such as Alzheimer peptides and chemokines, in the aqueous humor (AH) samples taken from patients with cataract only, or cataract and 1 other ocular disease. METHOD

Electrocardiograms are routinely obtained in clinical follow-up of patients with asymptomatic aortic stenosis (AS). The association with aortic valve, left ventricular (LV) response to long-term pressure load, and clinical covariates is unclear and the clinical value is thus uncertain. Data from clinical examination, electrocardiogram, and echocardiogram in 1,563 patients in the Simvastatin and Ez

Popular Abstract in Swedish Katalytisk omvandling av enkla kolväten till mer användbara substanser m.h.a. homogena/lösliga komplex av övergångsmetaller är ett mycket viktigt ämnesområde inom metallorganisk kemi. För att förstå hur processen går till har ett stort antal modellföreningar syntetiserats genom åren där man har studerat hur kol-väte eller kol-kol bindningar kan brytas. Man bör notera atThe work presented in this thesis deals with metallacyclic late transition metal complexes, obtained by intramolecular Csp3-H activation, and the application of such compounds in catalysis. The new hemilabile P,O phosphines N-methyl-N-propionyl-2-(diphenylphosphino)benzylamine (DPPAM), o-(diphenylphosphino)benzoic acid ethyl ester (DPPES), o-(diphenylphosphino)benzoic acid methyl ether (DPPET) and

The design and analysis of specular radar absorbing materials are investigated throughout the dissertation. Although the topic has been investigated for more than 60 years by many researchers and numerous designs have been proposed, still many technical challenges are remained unanswered. The basic questions are, e.g., the optimal thickness of a design, the possibility of utilization of unconventi

Popular Abstract in Swedish Ateroskleros, ofta kallad åderförkalkning, är en sjukdom som påverkar stora och medelstora artärer såsom aorta, kranskärl, karotis och perifera artärer. Åderförkalkning i kranskärlen orsakar 70 % av dödsfallen hos dessa patienter och räknas som den främsta dödsorsaken i västvärlden. Cerebrovaskulär sjukdom orsakar 20 % av dödsfallen och är den tredje vanligaste dödsorsaAtherosclerosis is the leading cause of death and disability in the western world. Its clinical complications include acute myocardial infarction, sudden death and stroke. Thirty to 40 % of all ischemic strokes are caused by a carotid stenosis. The acute clinical event is triggered by an occluding thrombosis and even more frequently by embolization. Besides the degree of stenosis, the structure of

The aim of the work presented in this thesis is the improvement of xylose fermentation performance of recombinant Saccharomyces cerevisiae strains expressing XYL1 and XYL2 from Pichia stipitis, encoding xylose reductase (XR) and xylitol dehydrogenase (XDH). A recombinant strain of S. cerevisiae, fermenting both xylose and glucose to ethanol could decrease the production cost of ethanol from ligno-

The human genome, in common with all mammalian genomes, carries a high load of inheritable retroviral sequences. We have identified and characterized a novel family of these endogenous retroviruses and have named this family HERV-F as based on the primer binding sites of three members. The HERV-Fs are C-type endogenous retroviruses that have unique gag, pol and env regions that are, based on phylo

This thesis work is concerned with the efficient layout and operation of substations, i.e. those district heating (DH) system units which connect the network and internal building heating systems, such as radiator heating systems and domestic hot water distribution networks. The ambition was to make realistic investigations closely related to practical technologies within the field. The themes of

Popular Abstract in Swedish Sammanväxningar i buken är en normal reaktion efter skador i bukhinnan och utvecklas efter ett inflammatoriskt svar och det efterföljande läkningsförloppet. Många sammanväxningar bildas inom 24-48 timmar efter skadan och tillbakabildas normalt efter 5-7 dagar. Många av de sammanväxningar som kvarstår kan ses som en obalans i de system som bildar ärr (fibros) och löser dIntraabdominal adhesions are formed after most operations and a limited number of studies have to examine the long-term spectrum of adhesion-related disorders and the cost associated with this. Only a few numbers of antiadhesive agents are available which, however, do not decrease the actual morbidity that follows intraabdominal adhesions, such as small bowel obstruction, infertility and pain. Fut

The distribution of sediment-dispersed extraterrestrial chromite grains and other Cr-rich spinels (> 63 mu m) has been studied in Middle Ordovician Orthoceratite Limestone from two quarries at Kinnekulle, southern Sweden. In the Thorsberg quarry, all similar to 3.2 m thick sequence of beds previously shown to be rich in fossil meteorites is also rich in sediment-dispersed extraterrestrial chromite

Aims: To examine whether genetic variants that predispose individuals to type 2 diabetes (T2D) could predict the development of diabetes after gestational diabetes mellitus (GDM). Methods: 13 SNPs (FTO rs8050136, CDKAL1 rs7754840 and rs7756992, CDKN2A/2B rs10811661, HHEX rs1111875, IGF2BP2 rs1470579 and rs4402960, SLC30A8 rs13266634, TCF7L2 rs7903146, PPARG rs1801282, GCK rs1799884, HNF1A rs116928

The endosymbiotic theory for the origin of mitochondria requires substantial modification. The three identifiable ancestral sources to the proteome of mitochondria are proteins descended from the ancestral alpha -proteobacteria symbiont, proteins with no homology to bacterial orthologs, and diverse proteins with bacterial affinities not derived from alpha -proteobacteria. Random mutations in the f

Previous studies have shown that intrastriatal transplants of dopamine (DA)-rich fetal ventral mesencephalic (VM) tissue can correct denervation-induced changes in the cellular expression of neuropeptide and receptor mRNAs in the rat Parkinson model. However, with the standard transplantation approach normalization of all cellular parameters has not been obtained. This may be due either to the inc

The aim of this study was to investigate the short-term (2 weeks) effects of the herbicide metsulfuron methyl alone and in combination with the insecticide cypermethrin in freshwater enclosures (80 1). We used a factorial design with four levels of herbicide (0, 1, 5, 20 mug/1) and two levels of insecticide (0 and 0.05 mug/1). The root growth of the macrophyte species Elodea canadensis and Myrioph

This study compared the toxic effects of adding chromium (Cr), zinc (Zn), lead (Pb), molybdenum (Mo), nickel (Ni), and cadmium (Cd) at three dose levels to mor layer samples in laboratory experiments. Microbial activity in the form of soil respiration was monitored for 64 days. At the end of the experimental period, the composition of the soil microbial community structure was analysed by phosphol

Precipitation suppression due to an increase of aerosol number concentration in stratiform cloud is well-known. It is not certain whether the suppression applies for deep convection. Recent studies have suggested increasing precipitation from deep convection with increasing aerosols under some, but not all, conditions. Increasing precipitation with increasing aerosols can result from strong intera

Dyskinesia seen in the off-state, referred as graft-induced dyskinesia (GID), has emerged as a serious complication induced by dopamine (DA) cell transplantation in parkinsonian patients. Although the mechanism underlying the appearance of GID is unknown, in a recent clinical study the partial 5-HT(1A) agonist buspirone was found to markedly reduce GID in three grafted patients, who showed signifi