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Suppression by calcium of serum levels of intact parathyroid hormone in patients with primary hyperparathyroidism

Primary hyperparathyroidism (pHPT) is associated with a right-shifted relation between parathyroid hormone (PTH) secretion and calcium. However, it is also possible that a decreased suppressibility of PTH secretion by calcium is important for maintaining hypercalcemia in pHPT. We therefore compared the suppression of serum levels of intact PTH induced by a 1.5-gram oral calcium load in patients wi

Prediction of changes in bone density after operation for primary hyperparathyroidism

Primary hyperparathyroidism (pHPT) is associated with osteopenia. However, the individual variation in recovery in bone mass after surgery is large. Therefore, modes of prediction of the increase in bone mass after parathyroid surgery were investigated. Preoperatively and at one year after surgery bone mineral content (BMC) in the distal radius was measured with single photon absorptiometry techni

Innovative Solution for Additional Water Resources at the Jordan Valley

AL-Karama dam, the second largest dam in Jordan, was constructed in the Jordan valley area in the year 1979. Currently, the dam holds about 72% of its designed storage capacity with total dissolved solids concentration of 2.2%. The dam water was designed to irrigate 100 km2 of new reclaimed areas and to provide drinking water for more than 30,000 residences. In this work, solar desalination system

Large vein sampling for intact parathyroid hormone in preoperative localization of enlarged parathyroid glands

Unilateral neck exploration for primary hyperparathyroidism (pHPT) of old and high risk patients can be safely performed under local anesthesia, provided there is a correct preoperative side localization of the enlarged parathyroid gland. We performed large vein sampling and measured intact parathyroid hormones (PTH) with a new, highly sensitive immunoradiometric assay. The method was used before

Surgery for primary hyperparathyroidism performed under local anaesthesia

Patients with primary hyperparathyroidism are often elderly with cardiovascular disease and in some an operation might be hazardous owing to anaesthetic complications. A technique for operation for primary hyperparathyroidism under local anaesthesia is described. The method uses a unilateral approach. Seventeen consecutive patients operated on under local anaesthesia were compared with a group of

Biochemical variables associated with bone density in patients with primary hyperparathyroidism

OBJECTIVE: To clarify the association between primary hyperparathyroidism and cortical osteopenia.DESIGN: Open study.SETTING: Department of Surgery, University of Lund, Sweden.SUBJECTS: 38 patients with primary hyperparathyroidism.OUTCOME MEASURES: Correlation between bone density (measured by single photon absorption) and age; sex; serum concentrations of parathyroid hormone and ionised calcium;

Thallium-technetium subtraction scintigraphy of enlarged parathyroid glands after calcitonin stimulation of parathyroid hormone secretion

To improve the sensitivity of thallium-technetium subtraction scintigraphy for preoperative localization procedure of enlarged parathyroid glands in primary hyperparathyroidism, we administered calcitonin intramuscularly 4 hours before the scintigraphy in 14 consecutive patients. Injection of calcitonin reduced plasma levels of ionized calcium from 1.47 +/- 0.10 mmol/l to 1.41 +/- 0.09 mmol/l (p l

A genetic risk score for CAD, psychological stress, and their interaction as predictors of CAD, fatal MI, non-fatal MI and cardiovascular death

Background Psychological stress is an independent risk factor for cardiovascular disease (CVD), but the mechanism by which stress is associated with CVD is not entirely understood. Although genetic factors are implied in both stress responsivity and cardiovascular reactivity, no studies to date have investigated their interactions with stress for cardiovascular end points. The objective was to elu

Coping strategies and cancer incidence and mortality : The Japan Public Health Center-based prospective study

Background Psychological stress is a modifiable risk factor for health outcomes and can be managed through coping mechanisms. Biological and behavioral hypotheses have been proposed to explain the association between stress coping strategies and cancer outcomes. Methods The Japan Public Health Center-based study asked questions on coping behaviors in its 10-year follow-up survey. 55,130 subjects a

Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk : The JPHC Study

The association between alcohol intake and colorectal cancer (CRC) may vary secondary to single nucleotide polymorphisms (SNPs) in two pathways related to alcohol intake. 375 cases of CRC were identified among 38 373 Japan Public Health Center-based prospective Study (JPHC Study) participants who had returned a baseline questionnaire, reported no diagnosis of any cancer and provided blood samples.

Coping strategies and risk of cardiovascular disease incidence and mortality : The Japan Public Health Center-based prospective Study

Aims: Coping strategies may be significantly associated with health outcomes. This is the first study to investigate the association between baseline coping strategies and cardiovascular disease (CVD) incidence and mortality in a general population cohort. Methods and results: The Japan Public Health Center-based prospective Study asked questions on coping in its third follow-up survey (2000- 04).

The association between complete and partial non-response to psychosocial questions and suicide : The JPHC Study

Background: Non-participants to psychosocial studies have been shown to have higher mortality, and mortality differs between partial and complete responders to psychosocial questionnaires. Yet, there is very little information available directly linking survey response status with completing suicide. Methods: The study population consisted of the participants of the Japanese Public Health Center-b

Coping behaviors and suicide in the middle-aged and older japanese general population : The japan public health center-based prospective study

Purpose: Cross-sectional studies have shown an association between different coping styles and suicidal behavior. It is unknown whether there is any prospective association between coping behaviors and suicide in the general population. Methods: The study population consisted of participants of the Japanese Public Health Center-based Prospective Study. In the 10-year follow-up questionnaire, subje

Extensive reworking of Archaean crust within the Birimian terrane in Ghana as revealed by combined zircon U-Pb and Lu-Hf isotopes

Located in the southeastern parts of the Baoulé Mossi domain of the West African Craton, the Birimian terrane in Ghana is known to consist of predominantly juvenile crust emplaced during the Eburnean orogeny. Here we present novel coupled zircon U-Pb and Lu-Hf isotope data from nine Birimian granitoids intruding different domains from northwestern, western and southeastern Ghana. Sub-chondritic e(