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Sclerostin anibody treatment enhanced metaphyseal bone healing in rats

Sclerostin is the product of the SOST gene. Loss‐of‐function mutations in the SOST gene result in a high‐bone‐mass phenotype, demonstrating that sclerostin is a negative regulator of bone mass. Primarily expressed by osteocytes in bone, sclerostin is reported to bind the LRP5/6 receptor, thereby antagonizing canonical Wnt signaling and negatively regulating bone formation. We therefore investigate

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Abstract in Danish Japans nyvalgte regering har et stærkt parlamentarisk mandat, men mangler folkelig opbakning. Den kan regeringen vinde ved at få gang i landets økonomi og forsøge at sikre en mere stabil social udvikling.