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Radiolabeled targeting agents have emerged as valuable tools for the treatment of disseminated cancer. Monoclonal antibodies (mAbs) are widely employed as carriers for diagnostic and therapeutic radionuclides due to their exceptional specificity and affinity. However, their prolonged circulatory half-life can diminish diagnostic efficacy and increase radiation exposure to non-target tissues in the
Fatal accidents in UK’s manufacturing sector are expected to remain the same or increase in coming years. This paper has tried to combat this issue by adapting and further developing a previously defined Safety Framework for the Paint Sector, to evaluate the safety performance of a metal manufacturing facility. To achieve this, the original Safety Framework was updated to align with the current Br
This paper presents the first comprehensive analysis of the systematic archival erasure surrounding the mass killing of Afro-Caribbean laborers at Anna’s Hope during the Fireburn uprising on St. Croix in 1878. Although internal telegrams and eyewitness accounts refer explicitly to a "great slaughter" of Black insurgents at Anna's Hope on 3 October 1878, the incident is conspicuously absent from of
While research on the ramifications of automated decision-making (ADM) for welfare organisations is growing rapidly, less attention has been paid to elucidating the role and experiences of clients in the ADM process. This paper draws attention to how the performance of ADM policy in social assistance organisations working from an activation perspective is not merely a passive way of processing cli
In 1778, a large bronze bell was cast by royal bellfounder Michael Troschell in Copenhagen. Unlike most of his bells, which were destined for church towers, this one was sent to La Grange, the largest plantation on St. Croix in the Danish West Indies. The bell functioned as an instrument of discipline, structuring the workday for more than a thousand enslaved laborers. This paper explores the plan
Can compulsory military service breach human rights protections against slavery, servitude or forced or compulsory labour contrary to Article 8 of the International Covenant on Civil and Political Rights (‘ICCPR’) (and/or equivalent provisions in regional human rights instruments) and, in doing so, meet the threshold of persecution under the 1951 Convention Relating to the Status of Refugees? The
Verksamhetsstatistikens mödor och nyttor har aktualiserats genom kyrkomötesmotionen 2021 om Diakonins kunskap.I denna artikel presenterar Stig Linde lärdomar från andra organisationer, bland annat den finska lutherska kyrkan.
Negative symptoms in schizophrenia spectrum are associated with minimal treatment responses. The search for effective treatments is potentially hampered by heterogenous study-designs and sample characteristics depending on the intervention category. This PRISMA-compliant systematic review/synthesis aims to describe the literature on negative symptoms interventions for schizophrenia spectrum disord
Laser-induced fluorescence has been a staple technique for in-situ probing of radicals and atomic species for decades. The multi-photon equivalent is prevalent in a large variety of applications, where such excitation schemes enable the study of otherwise elusive species and systems. However, these variants inherently suffer from low signal intensities, impeding the broader use of multi-photon ima
Extremely thinned layers and possible folding make the dating of the deepest sections of ice cores especially challenging. Cosmogenic radionuclides have the potential to provide independent age estimates. The 36Cl/10Be ratio is largely independent of production rate changes that affect individual radionuclides and has an effective half-life of 384 kyr, making it an ideal tool for dating the new 1.
Levodopa provides effective symptomatic treatment for Parkinson's disease. However, nonmotor symptoms are often insufficiently relieved, and its long-term use is complicated by motor fluctuations and dyskinesia. To clarify mechanisms of levodopa-induced dyskinesia and pharmacological interventions aimed at reducing dyskinetic symptoms, we have here characterized the neurophysiological activity pat
In a global retrospective assessment, this study quantifies the potential impacts of croplands on biodiversity using the UNEP-Life Cycle Initiative's recommended method for land use that was proposed by the GLAM consensus working group for Global Guidance for Life Cycle Impact Assessment Indicators and Methods. The findings show the importance of using tools that account for both occupied area and
Disasters such as COVID-19 and the Russia–Ukraine war are drawing attention to the provisioning of food during crises. The main concern has been quickly establishing a stable food supply. However, climate change and public health concerns are shifting attention to the critical gap in identifying the minimal considerations that would adequately address ecological disaster food provisioning. A meta-
Although political governance guides education and research, there are options for researchers, educators and curators to act in the spirit of academic freedom. The deontological ethical guidelines stabilize the archaeological establishment no matter what kind of work. The utilitarian dimensions within archaeological research and higher education open up for critical thinking.Twisting and turning,
Comparative genomic analysis often involves visualization of alignments of genomic loci. While several software tools are available for this task, ranging from Python and R libraries to stand-alone graphical user interfaces, a tool is lacking that offers fast, automated usage and the production of publication-ready vector images. Here we present LoVis4u, a command-line tool and Python API designed
The paper identifies three interconnected scales of global politics in Artificial Intelligence (AI) and healthcare. It provides a multilevel framework for policy makers to situate hybrid-human AI collaborations in healthcare within broader global political concerns.
BACKGROUND: Lead is an established causal risk factor for coronary heart disease. Atherosclerosis may be the key mediator for this association, but evidence from studies in humans is limited. Our objective was to test the hypothesis that environmental lead exposure is associated with coronary atherosclerosis. METHODS: We used cross-sectional data from the SCAPIS (Swedish Cardiopulmonary Bioimage S
