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Researchers from the Jakobsson Group at Lund University have discovered how a hidden piece of DNA, known as a transposable element, disrupts normal gene function in a disease called X-Linked Dystonia-Parkinsonism (XDP). Published in Nature Structural and Molecular Biology, their findings uncover the epigenetic processes that lead to changes in gene expression linked to XDP, offering new insights i

https://www.molecular-neurogenetics.lu.se/article/how-hidden-genetic-elements-trigger-rare-neurodegenerative-disorder - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. Interested in how we work with cutting out bad genes and pasting in new, healthy ones? In this case, you might find the below article on new gene techniques and our research very intersting! På svenska: Är du nyfiken på hur vi arbetar med att klippa ut de dåliga generna och klistra in nya friska gener? Då kan den följ

https://www.molecular-neurogenetics.lu.se/article/om-att-klippa-och-klistra-i-dna-how-cut-and-paste-gene-sequence - 2026-05-09

Läs här om vår senaste publikation som presenterar en direkt länk mellan Huntingtons sjukdom och en grundläggande process som kallas autofagi.       Publikation: Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation  

https://www.molecular-neurogenetics.lu.se/article/nya-ron-om-huntingtons-sjukdom-publiceras - 2026-05-09

Interested in progress on large-scale production of living brain cells? Are you interested in progress on large-scale production of living brain cells? You can find out more in our latest paper REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.  

https://www.molecular-neurogenetics.lu.se/article/new-paper-large-scale-production-living-brain-cells - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. New publication! Please click here to read about our latest publication TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells.Also, please click here to go to a short presentation of this research in Science: Science

https://www.molecular-neurogenetics.lu.se/article/viruses-genome-are-important-our-brain - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. We're very happy to announce that our former PhD student Rebecca Petri has received the Best Thesis Award 2017 from the Neurobiology Section of Lund University. Well done, Rebecca! 

https://www.molecular-neurogenetics.lu.se/article/best-thesis-award-2017-goes-rebecca-petri - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. 2019-04-09. Today we celebrated the official nailing of Per Ludvik Brattås' thesis entiteled "The Epigenetic Impact of Transposable Elements in Human Brain Development". Per's defence will take place on April 26th at 13 o'clock at the Segerfalk lecture hall (BMC, A10) - you are most welcom to join us! 

https://www.molecular-neurogenetics.lu.se/article/ludviks-thesis-officially-nailed - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. We are very happy to announce that Per Ludvik Brattås has successfully defended his thesis entitled "The Epigenetic Impact of Transposable Elements in Human Brain Development". Congratulations, Dr. Brattås!

https://www.molecular-neurogenetics.lu.se/article/congratulations-dr-brattas - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. We're happy to present our most recent publication "Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors" published on July 18th. Our study sheds light on the darker parts of our genetic heritage. To find out more please click on the below link.Lund University's pr

https://www.molecular-neurogenetics.lu.se/article/new-publication-nature-communications - 2026-05-09

Läs den spännande debatten om den nya gentekniken Crispr, skriven av forskare från gruppen Crispr ideas vid Pufendorfinstitutet, Lunds universitet, på SvD Debatt. SvD Debatt: ”Vi måste ta ställning till nya gentekniken” Aftonbladet: "Den nya gensaxen måste diskuteras"   Om debattörerna: Karin Broberg, professor i arbets- och miljömedicin Ingrid Dunér, doktorand i idéhistoria Kristofer Hansson, doc

https://www.molecular-neurogenetics.lu.se/article/pa-svenska-nya-gentekniken-kraver-en-bred-debatt - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. Today we celebrated official nailing of Daniela Grassi's thesis "Development and Applications of in vitro Models to Study Human Brain Evolution and Disease". The defence will take place on Thursday April 23rd at 9.00 o'clock and it will be made availably digitally for you to join!

https://www.molecular-neurogenetics.lu.se/article/nailing-completed - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. Daniela Grassi will be defending her thesis on Thursday 23rd of April 2020. Here, Daniela tells us about her research in the Molecular Neurogenetics group. Please click here for full article: https://www.stemcellcenter.lu.se/article/thesis-defence-interview-daniela-grassi 

https://www.molecular-neurogenetics.lu.se/article/thesis-defence-interview-daniela-grassi - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. Interested in autophagy or Huntington disease? Please click here to go to our newest publication Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease and to more information on our work in the field.

https://www.molecular-neurogenetics.lu.se/article/new-article-autophagy-and-treatment-huntington-disease - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. Read here about Christopher Douse who joined our group at the beginning of 2020 and works on developing a research programme on newly-discovered guardians of the human genome. For article please click on the following link: https://www.stemcellcenter.lu.se

https://www.molecular-neurogenetics.lu.se/article/meet-christopher-douse - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. Read about how the CRISPR facility at Lund Stem Cell Center can help you with your experiments CRISPR is a simple yet powerful Nobel Prize winning technology that allows sequence specific editing and manipulation of DNA sequences. The CRISPR facility at Lund Stem Cell Center is here to help you with your projects usin

https://www.molecular-neurogenetics.lu.se/article/lund-crispr-facility-here-help - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. Researchers from Lund Stem Cell Center highlight the importance of controlling viral elements that reside in the genome and how their activation during development may contribute to brain disorders later in life. To read the article, please go to: https://www.stemcellcenter.lu.se/article/activation-ancient-viruses-dur

https://www.molecular-neurogenetics.lu.se/article/activation-ancient-viruses-during-brain-development-causes-inflammation - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. Har du koll på vad stamceller gör och kan? Testa vad du vet med Sydsvenskans quiz ”Svara Lund”: Vad kan du om stamceller? För att komma till Sydsvenskans quiz klicka här. frågor.pdf   rätta svar.pdf

https://www.molecular-neurogenetics.lu.se/article/sydsvenskan-quiz-svara-lund-vad-kan-du-om-stamceller - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. Är du intresserad i vår forskning? Läs om vår studie som visar att dysreglering av endogena retrovirus under hjärnans utveckling kan leda till både inflammation i hjärnan och genuttrycksmönster som är förbundna med olika neurologiska sjukdomar senare i livet. För att läsa hela artikeln, klicka här.

https://www.molecular-neurogenetics.lu.se/article/vetenskap-halsa-aktivering-av-gamla-virus-orsakar-inflammation-senare-i-livet - 2026-05-09

This article is over 5 years old, and the information may therefore be outdated. Click the link below to listen to the latest Stem Cell Podcast - featuring Johan Jakobsson Ep. 192: “Gene Expression and the Brain” Featuring Dr. Johan Jakobsson:  https://stemcellpodcast.com/ep-192-gene-expression-and-the-brain-featuring-dr-johan-jakobsson    

https://www.molecular-neurogenetics.lu.se/article/stem-cell-podcast-featuring-johan-jakobsson - 2026-05-09

Read about our research on a previously overlooked part of our DNA, so-called non-coded DNA. Our DNA is very similar to that of the chimpanzee, which in evolutionary terms is our closest living relative. Stem cell researchers at Lund University in Sweden have now found a previously overlooked part of our DNA, so-called non-coded DNA, that appears to contribute to a difference which, despite all ou

https://www.molecular-neurogenetics.lu.se/article/what-makes-us-human-answer-may-be-found-overlooked-dna - 2026-05-09