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The HIV-1 epidemic in Ethiopia – transmission patterns, antiretroviral drug resistance and treatment outcomes

A comprehensive understanding of local HIV epidemiology is essential for monitoring transmission, designing, implementing, and evaluating HIV intervention strategies. In paper I, we used a total of 1276 HIV-1 subtype C pol sequences and employed state-of-art phylogenetic and phylodynamic tools to describe the molecular epidemiology of HIV in Ethiopia. Our results showed that the HIV epidemic in Et

The Risk of Endometrial Malignancy and Other Endometrial Pathology in Women with Abnormal Uterine Bleeding : An Ultrasound-Based Model Development Study by the IETA Group

Objectives: The aim of this study was to develop a model that can discriminate between different etiologies of abnormal uterine bleeding. Design: The International Endometrial Tumor Analysis 1 study is a multicenter observational diagnostic study in 18 bleeding clinics in 9 countries. Consecutive women with abnormal vaginal bleeding presenting for ultrasound examination (n = 2,417) were recruited.

Analysis of Changes in the Beat-to-Beat P-Wave Morphology Using Clustering Techniques

Several pathologies related to the atrial electrical activity can be detected in the electrocardiogram P-wave. A study on the beat-to-beat P-wave morphology changes of 89 ECG signals is performed in this article. An algorithm based on the embedding space techniques has been used to extract the P-wave information of the ECG. The P-waves obtained in several of these ECGs exhibit intermittent morphol

Association between central haemodynamics and renal function in advanced heart failure : a nationwide study from Sweden

Aims: Renal dysfunction in patients with heart failure (HF) has traditionally been attributed to declining cardiac output and renal hypoperfusion. However, other central haemodynamic aberrations may contribute to impaired kidney function. This study assessed the relationship between invasive central haemodynamic measurements from right-heart catheterizations and measured glomerular filtration rate

Contrasting characteristics, changes, and linkages of permafrost between the Arctic and the Third Pole

Permafrost degradation poses serious threats to both natural and human systems through its influence on ecological–hydrological processes, infrastructure stability, and the climate system. The Arctic and the Third Pole (Tibetan Plateau, TP hereafter) are the two northern regions on Earth with the most extensive permafrost areas. However, there is a lack of systematic comparisons of permafrost char

Unilateral or Bilateral Retroperitoneal Lymph Node Dissection in Nonseminoma Patients with Postchemotherapy Residual Tumour? Results from RETROP, a Population-based Mapping Study by the Swedish Norwegian Testicular Cancer Group

BACKGROUND: The distribution of retroperitoneal lymph node metastases for patients with nonseminoma and a residual tumour of 10-49 mm in a population-based setting is unknown. This information is needed to justify selection of patients for a unilateral template resection. OBJECTIVE: To describe the location of retroperitoneal metastases and recurrences in patients with nonseminoma germ cell tumour

The PEPSI exoplanet transit survey (PETS) I : Investigating the presence of a silicate atmosphere on the super-earth 55 Cnc e

The study of exoplanets and especially their atmospheres can reveal key insights on their evolution by identifying specific atmospheric species. For such atmospheric investigations, high-resolution transmission spectroscopy has shown great success, especially for Jupiter-type planets. Towards the atmospheric characterization of smaller planets, the super-Earth exoplanet 55 Cnc e is one of the most

Transgressing purity: Intersectional negotiations of gender identity in Swedish schools

The vulnerability of gender nonconforming young people is all too well documented. Arguably, “trans issues” in schools are not restricted to transphobic comments, and need to be analyzed intersectionally. Guided by Lugones’ discussion of the politics of purity read together with the analysis of cisnormativity, this article draws on interviews with Rakel, Robin and Mika, who were part of a larger s

Idén om en ”det enda syftets” kärnvapendoktrin : Konsekvenser för USA:s allierade, för Nato och den nukleära delaktigheten

USA:s president Joseph R Biden överväger att ändra USA:s politik för kärnvapenavskräckning. Sedan kärnvapenålderns början har Washington alltid förklarat att man kan komma att svara med kärnvapen som vedergällning, inte bara på attacker med kärnvapen, utan även på icke-nukleära aggressioner. Denna deklaratoriska politik kan snart komma att skärpas: Biden skulle vilja minska kärnvapnens roll genom U.S. President Joseph R. Biden is considering changing the United States’ policy on nuclear deterrence. Since the beginning of the nuclear age, Washington has always declared that it could respond with nuclear retaliation not only to attacks with nuclear weapons, but also to non-nuclear aggression. That declaratory policy may soon be tightened: Biden would like to reduce the role of nuclear weapon

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Ten per cent of patients with colorectal cancer will develop peritoneal metastases. These metastases are known to have a lesser response to systemic chemotherapy than liver- and lung metastases. Randomized studies have shown that adding cytoreductive surgery and heated intraperitoneal chemotherapy (HIPEC) to this treatment gives a better chance of survival. Recently, a randomized study failed to s

Quantum error correction in the noisy intermediate-scale quantum regime for sequential quantum computing

We use density-matrix simulations to study the performance of three distance three quantum error correction (QEC) codes in the context of the rare-earth (RE) ion-doped crystal platform for quantum computing. We analyze pseudothresholds for these codes when parallel operations are not available, and examine the behavior both with and without resting errors. In RE systems, resting errors can be miti

Optical control of the complex phase of a quantum ground-state amplitude

We discuss how coherent driving of a two-level quantum system can be used to induce a complex phase on the ground state and we discuss its geometric and dynamic contributions. While the global phase of a wave function has no physical significance, the coherent dynamics in a two-level subspace provides relative phases and is an essential building block for more advanced dynamics in larger systems.

Designing and Implementing a Population-based Organised Prostate Cancer Testing Programme

BACKGROUND: European guidelines recommend that well-informed men at elevated risk of having prostate cancer (PCa) should be offered prostate-specific antigen (PSA) testing with risk-stratified follow-up. The Swedish National Board of Health and Welfare recommends against screening for PCa but supports regional implementation of organised prostate cancer testing (OPT).OBJECTIVE: To report the proce

Terpene emissions from boreal wetlands can initiate stronger atmospheric new particle formation than boreal forests

Aerosols and their interaction with clouds constitute the largest uncertainty in estimating the radiative forcing affecting the climate system. Secondary aerosol formation is responsible for a large fraction of the cloud condensation nuclei in the global atmosphere. Wetlands are important to the budgets of methane and carbon dioxide, but the potential role of wetlands in aerosol formation has not

Quantitative assessment of the impact of climate change on creep of concrete structures

Creep of concrete structures is in most cases regarded as a serviceability problem that may have impacts on maintenance and repair costs but cannot lead to structural collapse. However, several structural collapses during the past decades have been, at least partly, attributed to excessive creep deformations. Recent studies suggest that concrete creep may be further exacerbated by climate change.