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In adipocytes, PDE3B (phosphodiesterase 3B) is an important regulatory effector in signalling pathways controlled by insulin and cAMP-increasing hormones. Stimulation of 3T3-L1 adipocytes with insulin or the beta(3)-adrenergic receptor agonist CL316243 (termed CL) indicated that insulin preferentially phosphorylated/activated PDE3B associated with internal membranes (endoplasmic reticulum/Golgi),
Knowledge of the morphology of Manota unifurcata LUNDSTRÖM, 1913 is deepened by a detailed description and illustration of the male genitalia. Based on a study of the characters of the male genitalia in specimens from various countries, it is reconfirmed that M. unifurcata is the only species of Manota WILLISTON in Europe. Its geographic distribution is reviewed, and is augmented by new records fr
The increased prevalence of individuals with Autism Spectrum Disorders (ASD) challenges society to evaluate the quality and efficacy of community based psycho-pedagogical programmes in order to achieve progress and to attain an acceptable level of quality of life for its citizens. The overarching aim of this thesis was to gain knowledge about staff’s pedagogical work and to provide a method for as
Results are presented of a search for particles decaying into final states with significant missing transverse momentum and exactly two identical flavour leptons (e, mu) of opposite charge in root s = 7 TeV collisions at the Large Hadron Collider. This channel is particularly sensitive to supersymmetric particle cascade decays producing flavour correlated lepton pairs. Flavour uncorrelated backgro
Power supply is a social necessity, and will so continue to be in the near future. Therefore, safe and steady deliverance of power supply is a fundamental duty of the societies and the preparedness of the vulnerability of the infrastructures is highly prioritized. The power supply comprises every component needed for transmission of electrical power from generation to consumption, power transform
In the context of escalating environmental consciousness, this thesis scrutinizes urban sustainability, with a specific focus on Amsterdam's Schoonschip sustainable housing project. The investigation delves into the nuanced realm of green design, probing its potential and constraints in steering residents towards sustainable practices. This study unveils the subtle yet impactful role of gree
Lakes with increased water colour levels have been observed in many locations in the northern hemisphere, a phenomenon that is called brownification. The driving components of brownification are dissolved organic matter (DOM) and iron, which are affected by rainfall patterns as a large fraction originates from terrestrial sources. Brownification has many detrimental effects for the ecosystem, amon
År 2017 togs beslut i Sveriges riksdag att anta ett nytt klimatmål där Sverige år 2045 ska ha noll nettoutsläpp av växthusgaser för att därefter ha negativa växthusgasutsläpp. Utifrån detta mål ställer Trafikverket vidare krav på sin verksamhet och sina väg- och järnvägsprojekt. Trafikverkets mål är att infrastrukturen ska vara klimatneutral till år 2050 med delmål att minska växthusgasutsläppen mIn 2017 the Swedish Parliament implemented a new national goal for limiting climate change. The goal is to have zero net emissions of greenhouse gases by year 2045 which will ultimately lead to negative net emissions. Further, the Swedish Transport Administration adapted the goal of making Sweden’s infrastructure climate neutral by the year 2050, with the milestones of reducing the emissions from
Introduction: The world has witnessed a global trend of increasing obesity, which is directly linked to non-communicable diseases, such as type 2 diabetes (T2D). The epidemic of obesity is largely associated with consumption of high calorie diets and low physical activity. Food choice and exercise have a big impact to prevent obesity and T2D making these diseases highly related to personal lifesty
This thesis analyses the impact of EU citizenship on EU citizens studying in another EU Member State, Lund, Sweden in order to find out whether there is an ‘added value’ for EU citizens when exercising their rights as EU citizens. In the first part, a short introduction to the background of EU citizenship, the rights it grants and student mobility in the EU is presented. The second part illustrate
The thesis aims at supplementing a critique of the existing international instruments, regional responses and national legislation of the Arctic related to marine environmental protection. With this aim in view, the thesis satisfies its objective by proposing a Bipartite “Arctic Council” acting as a conglomeration of the Arctic States and the Flag States with a hybrid “Arctic treaty”, which is an
Current research shows that the number of workless people living in social housing is disproportionately high in comparison to other housing tenures. The aim of the Thesis is to examine the pathways into work available to social housing tenants, to better understand the phenomena of worklessness. Our object of study is that of residents within a social housing neighbourhood in Pennywell. A case st
A search for strongly produced supersymmetric particles using signatures involving multiple energetic jets and either two isolated same-sign leptons (e or μ), or at least three isolated leptons, is presented. The analysis relies on the identification of b-jets and high missing transverse momentum to achieve good sensitivity. A data sample of proton-proton collisions at s=13 TeV recorded with the A
Background and aims:Heart transplantation (HT) constitutes the ultimate treatment choice for end-stage heart failure. Following HT, patients require life-long immunosuppressive treatment to prevent allograft rejection. Although survival has steadily increased over the last few decades, issues related to under- and over-immunosuppression remain common and continue to represent one of the most impor
Background--Thrombus aspiration is still being used in a substantial number of patients despite 2 large randomized clinical trials showing no favorable effect of routine thrombus aspiration during primary percutaneous coronary intervention in patients with STsegment- elevation myocardial infarction. The aim of this observational study was to evaluate the impact of thrombus aspiration on mortality,
Recent randomised trials have demonstrated a survival benefit for a front-line ipilimumab and nivolumab combination therapy, and pembrolizumab and axitinib combination therapy in metastatic clear-cell renal cell carcinoma. The European Association of Urology Guidelines Panel has updated its recommendations based on these studies. Patient summary: Pembrolizumab plus axitinib is a new standard of ca
Gender equality is widely accepted as an important explanatory factor for the occurrence of intimate partner violence (IPV) against women. However, the relationship is not straightforward, as high country-level gender equality is not always associated with lower IPV prevalence. We apply ‘multilevel analysis of individual heterogeneity and discriminatory accuracy’ (MAIHDA) to (i) quantify the exten
Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investig
Objectives Early diagnosis and timely treatment are key elements of a successful healthcare system. We assessed the role of socioeconomic and cultural norms in accelerating or decelerating uptake and utilisation of health technologies into policy and practice. Setting Secondary and tertiary level healthcare facilities (HCFs) in three East African countries. Level of HCF was selected based on the W
