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Background and aim - The development of clinical manifectations due to an eroded or ruptured atherosclerotic plaque, or occluded vessel, are one of the major causes of death world wide. It has been known for some time that atherosclerosis develops due to retention and modification of LDL particles in the vessel wall and the subsequent triggering of the immune system. The research presented within
Popular Abstract in Swedish Den här avhandlingens syfte var att undersöka hur väl barn kan återberätta en bevittnad händelse och vid behov identifiera en misstänkt gärningsman i en ”lineup”, en vittneskonfrontation där en misstänkt tillsammans med fem personer som liknar den misstänkte presenteras på fotografier. Tre studier genomfördes. Den första studien undersökte barns förmåga att återberätta Through centuries, witnesses to crimes have played an important role for the police to get a conviction of the culprit. This dissertation examined how accurate children are as witnesses of events and when participating in lineups. In Study 1, participants were tested with free recall and focussed questions. Children aged 8-9 years, 11-12 years and adults in two experiments witnessed film events
BACKGROUND: Metabolic dysfunctions are associated with increased cancer morbidity and rapid tumor progression. The alpha1-oleate complex has been used successfully to treat bladder cancer in a placebo-controlled Phase II study. Studies of the related BAMLET complexes recently identified effects on metabolism, suggesting additional functions of the "HAMLET family" of tumoricidal complexes.AIMS: To
Allergy, characterised by antibody responses of the IgE isotype, is a major health concern. The set of monoclonal human IgE used for studying the molecular mechanisms of allergies is limited. Single-cell sequencing offers opportunities to establish novel antibodies for researching, diagnosis, and treatment of allergies. We describe and exploit a pipeline for generating recombinant IgE directly fro
In 2022, the Intergovernmental Panel on Climate Change (IPCC) established that global greenhouse gas emissions trajectories are not on track to limiting warming to less than 2 ° C above pre-industrial averages (IPCC 2022a). Given that broader progress towards ambitious climate change and sustainability goals remains incremental, a whole-of-society approach, including transformative innovation in t
Background: Ipilimumab, a monoclonal antibody against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), was the first approved checkpoint inhibitor; however, its use is hampered by treatment-related adverse events (TRAEs). ATOR-1015 is a bispecific antibody targeting CTLA-4 and OX40 designed to direct the effect to the tumor microenvironment and thereby improve the response rate and reduce TRA
Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists regarding the inflammatory response to Gram-positive anaerobic cocci (GPAC). To explore the ability of GPACs to induce monocyte activation, we compared two GPAC species, Parvimonas micra and Peptoniphilus harei, with E. coli, a major cause of bloodstream infections. We stimulated w
Streptococcus pyogenes, also known as group A Streptococcus (GAS), is a Gram-positive bacterial pathogen responsible for approximately 500,000 deaths globally per year. Therefore, surveillance of invasive GAS infections is of critical importance in understanding societal transmission. In this study, we propose an optical DNA mapping (ODM)-based assay for strain-level typing of S. pyogenes. Fluores
A sensitive and rapid enzyme-linked immunosorbent assay for simultaneous quantitation of free and IgA-complexed human protein HC was developed with monoclonal murine antibodies. The total amount of protein HC (free plus IgA-complexed) was measured by a competitive procedure while the protein HC-IgA complex was quantitated by a sandwich enzyme immunoassay. The amount of free protein HC was then obt
Hematopoietic stem cells (HSC), the ancestors of all blood cells, have the ability to give rise to mature effector cells through a series of developmental steps. This is a tightly regulated, though a highly dynamic process: on the one hand, dysregulation in steady-state could lead to under- or overgrowth of certain blood cell lineages, whereas, on the other hand, demands for certain mature blood c
The purpose of this study is to investigate how people express religious and national identities in the conflict-ridden Patani region of southern Thailand. In a historical framework of disputes over territory and political legitimacy, where identities have developed in response to an emerging Thai nation, it is of relevance to understand the dynamics of these identities and to disclose how local p
Popular Abstract in Swedish En av de största orsakerna till svårt handikapp och död i västvärlden är traumatisk hjärnskada som uppstår till följd av våld mot huvudet. Utav vuxna och barn är det generellt sett barn som klarar sig bättre efter våld mot huvudet men det är ändå till stor del barn som söker akutmottagning p.g.a. skallskada. De flesta av barnen har en så kallad lätt skallskada (ca 90 %)Traumatic head injury is one of the leading causes to severe morbidity and death among children. Specific and national management guidelines for pediatric head injuries are lacking in Sweden, and management routines are consequently based on adult guidelines or local guidelines. The objectives of this thesis were to investigate the current management of pediatric head injury in Sweden and to explo
Popular Abstract in Swedish Nivån på arbetsproduktivitet är särskilt betydelsefull i utvecklingsländer där det mesta av byggnadsarbetet utförs manuellt. Tidigare forskning har konstaterat att produktiviteten i byggindustrin är låg och i några fall sjunkande. Bristande produktivitet hos byggnadsarbetarna är en orsak till kostnadsöverskridande och förseningar av byggprojekt. Syfte med detta forskninProductivity of labour is particularly important especially in developing countries where most of the building work is still carried out on manual basis. Previous research has pointed out that productivity in the building industry is low and in some cases declining. Poor productivity of craftsmen is one of the causes of cost and time overruns on building projects. The objective of this research wa
Popular Abstract in Swedish Bakterier är små encelliga organismer som lever i nästan varje tänkbar miljö på jorden, inklusive i och på människor. Vi är kontinuerligt koloniserade av bakterier i bland annat våra luftvägar, munhålor och mag-tarmkanaler. Denna samexistens är oftast ömsesidigt fördelaktig, eller åtminstone ofarlig för oss människor, och det är känt att bakterier hjälper oss bryta ner Nontypeable Haemophilus influenzae (NTHi) is a remarkably proficient colonizer of the human respiratory tract. The aim of this thesis has been to characterize currently known, and identify novel, bacterial factors involved in the key processes of colonization and pathogenesis, namely adherence to host tissue and evasion of the host innate immunity. We have shown that the NTHi virulence factor Pr
Popular Abstract in Swedish En central frågeställning inom ekologin handlar om hur och varför organismers utbredning och antal varierar i tid och rum. Detta forskningsfält går under namnet populationsdynamik och är ämnet för min avhandling. Populationsdynamik handlar om mönster, slumpmässighet, förändringar; helt enkelt matematik! Av den anledningen är det inte bara önskvärt, utan faktiskt nödvändPopulation dynamics in space and time are manifested as changes in the distribution and abundance of organisms. To couple such patterns to the underlying processes is a central question in ecology and also key to successful management. In this thesis, I use theoretical models as well as time series data to analyze population dynamics in environments that are variable in space or time. An example o
Sepsis and subsequent multiple organ failure remain the major cause of mortality in intensive care units. Leukocyte-mediated tissue damage is a key feature in septic lung injury. Accumulating data suggest that platelets play a role in inflammation and tissue injury. However, the role of platelets in sepsis-induced leukocyte recruitment and lung edema formation in abdominal sepsis is not demonstrat
Popular Abstract in Swedish Varje år insjuknar ungefär 450 000 kvinnor i livmoderhalscancer (cervixcancer) i världen. Som en följd av screening för livmoderhalscancer, där kvinnor testar sig regelbundet för cellförändringar, har insjuknandet i livmoderhalscancer minskat. Det cellprov som används i screeningen lyckas dock inte upptäcka alla kvinnor som har ökad risk för framtida cancer. Humant papiDifferent types of human papillomavirus (HPV) vary in the extent they cause precursor lesions (CIN) and cancer. There are limited long-term efficacy data on HPV testing in primary screening Among 72 cervical cancers in Mozambique, HPV 16 and 18 were the most frequent HPV types (69% of cases). Comparing 108 cervical cancers cases and 517 matched controls nested within a population-based cohort in
We present a comparison of two-dimensional separation methods and how they affect the degree of coverage of protein expression in complex mixtures. We investigated the relative merits of various protein and peptide separations prior to acidic reversed-phase chromatography directly coupled to an ion trap mass spectrometer. The first dimensions investigated were density gradient organelle fractionat
Disruption of the homeostatic balance of intestinal dendritic cells (DCs) and macrophages (MQs) may contribute to inflammatory bowel disease. We characterized DC and MQ populations, including their ability to produce retinoic acid, in clinical material encompassing Crohn's ileitis, Crohn's colitis and ulcerative colitis (UC) as well as mesenteric lymph nodes (MLNs) draining these sites. Increased
