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Non-typeable Haemophilus influenzae (NTHi) is a human pathogen causing diseases in the upper and lower respiratory tract. Otitis media-prone children and adults with cystic fibrosis or chronic obstructive pulmonary disease, are repeatedly infected by NTHi Research in recent years brought to light the entry and survival of NTHi in epithelial cells and macrophages. Their internalization could be a
Popular Abstract in Swedish Kan immunförsvaret orsaka ledsjukdomar? Ett väl fungerande immunsystem är en förutsättning för att kroppen ska kunna bekämpa diverse sjukdomar orsakade av t. ex. virus och bakterier. En grundläggande egenskap hos immunsystemet är dess förmåga att kunna skilja på vad som är kroppens egna celler och molekyler och vad som är främmande. Man tror att vissa sjukdomar, så kalCollagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis, in which autoimmunity is induced by immunization with type II collagen (CII), a cartilage-specific protein. In the present work, alpha/beta T cells were shown to be required for CIA and for the production of anti-CII IgG antibodies, whereas gamma/delta T cells were neither necessary nor sufficient for development of CIA. A
Both Haemophilus influenzae type b (Hib) and nontypeable H. influenzae (NTHi) are important human pathogens causing invasive and mucosal infections. Currently there are number of vaccines available against Hib infections. Hib vaccines consist of the capsular polysaccharide antigen, polyribosyl ribitol phosphate (PRP) of Hib, coupled to different protein carriers. These vaccines are not effective a
A number of trends like globalisation, outsourcing, single sourcing, and leanness have together created a more vulnerable supply chain. This increased vulnerability has made supply chain risk issues a hot topic in academia as well as in industry. There has, however, been a lack of suitable models. The objective of this paper is to develop one such model – a conceptual model with the help of which
Popular Abstract in Swedish PAX FÖR MANETER! Evolutionen är den process som format det liv vi ser omkring oss. Ända sedan Darwins tid har man känt till att arter och djurgrupper uppstår genom att det finns en variation mellan individer och att då tillgångarna begränsas (såsom mat eller utrymme) blir det de bäst anpassade som överlever och fortplantar sig. Flercelliga djur har funnits på jorden i kDuring the course of evolution animal complexity and diversity is generated. The last couple of years it has become increasingly clear that morphologically diverse animals share a great deal of their genomic contents, and it must be the expression of regulatory genes in new setting, rather than the generation of new genes, that are fundamental for the generation of diversity. Basal phyla hold a ke
To study the absorption, metabolism and kinetics, the AKG ( in different concentrations) was administered intravenously, intra-portally, orally and directly into the ileum or duodenum of pigs, chronically fitted with portal and jugular catheters and T-shaped cannula at the duodenum and ileum. Additionally, this study was conducted to determine the influence of low pH, Fe2+ or/ and SO42- on AKG gut
Class I and class II MHC-restricted T cells specific for proteins present in myelin have been shown to be involved in autoimmunity in the central nervous system (CNS). It is not yet known whether CD1d-restricted T cells reactive to myelin-derived lipids are present in the CNS and might be targeted to influence the course of autoimmune demyelination. Using specific glycohpid-CD1d tetramers and clon
Popular Abstract in Swedish Politiskt deltagande är ett komplext studieobjekt. I denna studie har det politiska deltagandet studerats utifrån att det i grunden handlar om aktiviteter som syftar till att påverka offentliga beslut. Följande frågeställningar ligger till grund för studien: (1) Hur förhåller sig olika former av politiskt deltagande till idén om politisk jämlikhet? (2) Hur kan vi teorePolitical participation is promoted as a central component in a democracy. But what specifically is it that makes participation valuable and how do different forms of participation differ in regard to outcomes? A central aim of this study is to understand why different forms of participation produce different kinds of effects. The argument developed is that participation can be understood as havin
Egypt has one of the world's highest prevalences of hepatitis C virus (HCV) infection, with a majority of genotype 4 infections. To explore the genetic diversity of HCV in Egypt, sera from 131 Egyptians [56 from community studies, 37 chronic hepatitis patients, 28 hepatocellular carcinoma (HCC) patients and 10 patients with non-Hodgkin's lymphoma] were genotyped by restriction fragment-length poly
Combining nutritional supplements to achieve synergistic benefit is a common practice in the nutraceutical industry. However, establishing. added health benefit from a combination of natural ingredients is often assumed, untested and without regard to the principle of metabolic competition between the active components. Here, we report on the combination of a cat's claw water extract (C-Med-100, c
Cell surface proteins of the human gastric pathogen Helicobacter pylori, reference strain CCUG 17874, were extracted with acid glycine and fractionated by heparin affinity chromatography. The extracts were subsequently analysed using high-resolution two-dimensional gel electrophoresis (2-DE) and immunoblotting. Four proteins of low molecular masses (25-30 kDa) stained by Coomassie R-350, were iden
The evolution of human immunodeficiency virus type 1 (HIV-1) coreceptor use has been described as the acquisition of CXCR4 use linked to accelerated disease progression. However, CXCR4-using virus can be isolated only from approximately one-half of individuals with progressive HIV-1 disease. The other half continue to yield only CCR5-using viruses (R5 phenotype) throughout the course of disease. I
Streptococcus pyogenes of the M1 serotype is commonly associated with invasive streptococcal infections and development of streptococcal toxic shock syndrome. The M1 protein is a powerful inducer of inflammatory responses for several human cell types, but the reason why M1 protein-related strains is over-represented in invasive streptococcal diseases is still not understood. This study was underta
Using Deterministic Lateral Displacement devices optimized for sensitivity to particle length, we separate subpopulations of bacteria depending on known properties that affect their capability to cause disease (virulence). For the human bacterial pathogen Streptococcus pneumoniae, bacterial chain length and the presence of a capsule are known virulence factors contributing to its ability to cause
This paper seeks to improve the understanding of the interaction between patients with stroke and the physical environment in their home settings. Stroke care is increasingly performed in the patient's home. Therefore, a systematic review was conducted to identify the existing knowledge about facilitators and barriers in the physical environment of home settings for the stroke rehabilitation proce
Background: In order to increase coverage in the organized cervical screening program, self-sampling with HPV analyses has been suggested. Objectives: The aim was to compare human papillomavirus (HPV) mRNA detection in vaginal and urine self-collected samples with clinician-taken cervical samples and the corresponding clinician-taken histological specimens. Study design: Self-collected vaginal, ur
We investigated the activity of trimethoprim-sulfamethoxazole (SXT) against Mycobacterium tuberculosis. The MIC distribution of SXT was 0.125/2.4-2/38 mg/L for the 100 isolates tested, including multi- and extensively drug-resistant isolates (MDR/XDR-TB), whereas the intracellular MIC90 of sulfamethoxazole (SMX) for H37Rv was 76 mg/L. In an exploratory analysis using fAUC0-24h/MIC ≥25 as a potenti
