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Several findings link proteinase 3 (PR3) to small vessel vasculitis. Besides being a major target of anti-neutrophil cytoplasm antibodies (ANCA), previous findings have shown increased circulating levels of PR3 in vasculitis patients, increased levels of neutrophil membrane-PR3 (mPR3) expression and a skewed distribution of the − 564 A/G polymorphism in the promotor region of the PR3 gene. In this
Aqueous aerosols produced by nebulizers used in clinical situations can rapidly change size as the patient inhales. This is caused by air with a relative humidity (RH) lower than inside the nebulizer being entrained and mixed with nebulized aerosol during the inhalation maneuver. A way to assess the change in size is to measure the aerosol in a test method that reflects the clinical situation. The
In SPECT imaging of the chest, nonuniform attenuation correction requires use of a patient specific attenuation (p)map. Such a map can be obtained by estimating the regions of 1)the lungs and 2) the soft tissues and bones, and then assigning an appropriate value of attenuation coefficient (p) to each region. We proposed a method to segment such regions from the Compton scatter and photopeak window
In order to meet the unprecedented challenge of feeding an increasing population while curbing associated environmental impacts a fundamental change in the current food system is required. Such a shift needs an active facilitator who could set and implement the sustainability agenda in the food supply chain. Recently, it has been argued that retailers might become a vital agent of change towards s
Popular Abstract in Swedish Målsättningen för detta arbete var att isolera caveolae för att kunna studera deras struktur och funktion. Caveolae är omegaformade inbuktningar i cellmembranet, ungefär 50-150 nm i diameter. Caveolae finns i många typer of celler, men inte i röda och vita blodkroppar eller nervceller. Man tror att de har flera viktiga funktioner. Exempelvis kan caveolae transportera moThe intention of this work was to establish alternative purification methods to obtain highly purified caveolae from various tissues. In order to isolate caveolae, sufficiently pure plasma membranes are needed. A method is presented for the isolation of plasma membranes from lung tissue using a combination of conventional polyethylene glycol/dextran two-phase partitioning and affinity partitioning
Objectives: Smoking has been associated with higher disease activity and poor response to anti-tumour necrosis factor (anti-TNF) therapy in patients with rheumatoid arthritis (RA). We wanted to study the effect of smoking on response to therapy, disease activity measures, and drug survival in RA patients starting their first anti-TNF drug. Methods: In 2005, RA patients in a voluntary rheumatology
AIMS/HYPOTHESIS: Young adults in the early stages of their participation in the labour market may be particularly vulnerable to the effects of onset of a chronic disease. Our aim was to quantify the consequences of the onset of type 1 diabetes in young adults on annual earnings, using individual-level longitudinal data before and after the onset of diabetes. METHODS: The Econ-DISS database contain
To comprehensively characterize microRNA (miRNA) expression in breast cancer, we performed the first extensive next-generation sequencing expression analysis of this disease. We sequenced small RNA from tumors with paired samples of normal and tumor-adjacent breast tissue. Our results indicate that tumor identity is achieved mainly by variation in the expression levels of a common set of miRNAs ra
To examine the ascending projections from the headache-related trigeminocervical complex in rats, biotinylated dextran amine (BDA) was injected into the ventrolateral dorsal horn of segments C1 and C2, a region previously demonstrated to receive input from sensory nerves in cranial blood vessels. Following injections into laminae I-II, BDA-labelled terminations were found bilaterally in several nu
The scalar polarizability constant [alpha]0 for the 10, 11 2S1/2 and 9 2D5/2 states of 133Cs was measured i Stark effect experiment on a collimated atomic beam. The states were reached by a two-step excitation procedure involving a single-mode dye laser.
Objective. In the European Association of Urology guidelines on prostate cancer an extended pelvic lymphadenectomy (ePLND) is now recommended, instead of a dissection limited to the obturator fossae (lPLND). This recommendation relies on studies reporting that metastatic disease is identified twice as often with ePLND as with lPLND, with only moderately increased complications. However, these stud
In market-driven product development, it is important that the software product is released to the market at the right time, and offers higher quality than the competitors. In release planning, the allocation of development effort in investments into product enhancements, functions are competing with quality requirements for limited resources. In addition, it is important to find the right balance
This small-scale experiment was a first attempt at testing the theoretical framework of Processability Theory (PT), a well-established theory of Second Language Acquisition (SLA), against data from online brain imaging technology (Electroencephalography – EEG). Event Related Potentials (ERPs) were extracted for 15 advanced beginners/intermediate-level learners of Swedish who were presented with gr
In this thesis, I compare the economic development between one democracy, India, and one autocracy, China. The idea is to see whether democracy has anything to do with economic development in terms of growth and welfare. To my disappointment, I have found that democracy does not have a big impact on economic development. Instead, it seems that the economical development depends on the economical p
Commercial sexual exploitation of Children and Adolescents (CSEC) is an increasing problem all over the world and especially in developing countries with growing tourist industries. In these countries CSEC and Child Sex Tourism have become two often closely connected problems. In Costa Rica there are many NGOs and governmental institutions working with these problems through prevention, attention
To deal with the problems resulting from the current unsustainable pattern of resource utilization, the material life cycle of plastics should be extended. Extended producer responsibility (EPR) has been increasingly adopted as a strategy to redirect the material flow, but its contributions to the market development of recycled plastics have not been well researched. Norway is one of the countrie
