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Platelet activating factor (PAF) has been reported to produce a variety of airway effects including epithelial damage and increased airway-lung absorption of hydrophilic tracers. The present study examines effects of PAF on the guinea-pig tracheobronchial mucosa in vivo. Vehicle with and without PAF (4.0 and 8.0 nmol) was superfused onto the tracheobronchial mucosa. The levels of 125I-albumin, pre
We exhibit families of 4-CNF formulas over n variables that have sums-of-squares (SOS) proofs of unsatisfiability of degree (a.k.a. rank) d but require SOS proofs of size nΩ ( d ) for values of d = d(n) from constant all the way up to nδ for some universal constant δ. This shows that the nO ( d ) running time obtained by using the Lasserre semidefini
Så länge människan existerat har den haft behov av hjälp och vård i samband med olyckor och sjukdom, även om den medicinska förmågan genom årtusenden varit väldigt varierande. I dagens samhälle står akutmottagningen för kunskapen, resurserna och förmågan att hjälpa människor med många akuta medicinska behov. Välfungerande akutmottagningar har därför en central roll i det moderna samhället. Den endEmergency Departments (ED) have a central role in modern healthcare, providing emergent care regardless of complaint 24/7. However, EDs are often characterized by long waiting times for patients and a stressful working environment for staff. These are features or a resource and demand mismatch, internationally known as ED crowding. Although several reports and news articles have indicated that ED
Urban flood damage leads to major costs for private house owners, insurance companies, and water and wastewater utilities. Analysis of flood damage claims can be used to improve the understanding of the details of flood damage characteristics and reasons for drainage system failures. However, few studies have used data of this kind to investigate urban flood characteristics. We examined 3113 damag
INTRODUCTION: This article describes the views of European rural general practitioners regarding the strengths, weaknesses, opportunities and threats (SWOT) of the implementation of a chronic care model (CCM) in European rural primary care. METHODS: This was a mixed-methods online survey. Data were collected from 227 general practitioners between May and December 2017. Categorical data were analys
The stability of established memory T helper (Th)1/Th2 cells in chronic inflammatory diseases is not clear, and a shift of the cytokine balance could control chronic inflammation. In order to study the regulation of the Th phenotype of memory T cells, polyclonal T-cell lines and clones with a Th1, Th0 or Th2 phenotype were developed from rheumatoid synovial tissue. Th1 [interleukin (IL)-12 + anti-
Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life immune development, and the gut microbiota can impact host physiology in various ways, such as through the production of metabolites. However, few breastmilk-dependent microbial metabolites mediating host–microbiota interactions are currently known. Here, we demonstrate that breastmilk-promoted Bifidobacter
Checkpoint blockade therapies have changed the clinical management of metastatic melanoma patients considerably, showing survival benefits. Despite the clinical success, not all patients respond to treatment or they develop resistance. Although there are several treatment predictive biomarkers, understanding therapy resistance and the mechanisms of tumor immune evasion is crucial to increase the f
Recension av Bengt G. Nilsson: Israel och hennes fiender
Essä utgående från två assyrisk/syrianska självbiografier.
ObjectivePediatric anxiety disorders can have a chronic course and are considered gateway disorders to adult psychopathology, but no consistent predictors of long-term outcome have been identified. A single latent symptom dimension that reflects features shared by all mental health disorders, the p factor, is thought to reflect mechanisms that cut across mental disorders. Whether p predicts outcom
Trees growing at their altitudinal or latitudinal distribution in Fennoscandia have been widelyused to reconstruct warm season temperatures, and the region hosts some of the world’slongest tree-ring chronologies. These multi-millennial long chronologies have mainly beenbuilt from tree remains found in lakes (subfossil wood from lake-shore trees). We used aunique dataset of Scots pine tree-ring dat
Primary Sjogren's syndrome (SS) is a systemic autoimmune inflammatory disease characterized by focal lymphocytic infiltrates in the lachrymal and salivary glands and autoantibodies against the SSA/Ro and SSB/La antigens. Experimental studies have shown an activation of NF-B in primary SS. NF-B activation results in inflammation and autoimmunity and is regulated by inhibitory and activating protein
Bakgrund: Personer med psykisk ohälsa har ofta en nedsatt förmåga att bearbeta sinnesintryck. Tidigare har kopplingen mellan det individuella sättet att hantera sinnesintryck och olika sociodemografiska faktorer undersökts hos psykiskt friska personer, men studier gällande detta saknas för personer med psykisk ohälsa. Syfte: Att undersöka sensoriska bearbetningsmönster och deras eventuella kopplBackground: People with mental illness often have a reduced ability to process sensory inputs. Previously, the link between the individual way of dealing with sensory inputs and sociodemographic factors has been investigated in mentally healthy people, but there’s a lack of similar studies for people with mental illness. Aim: To investigate sensory processing patterns and their possible connecti
The wind power industry has long remained passive on broader sustainability issues, grounded in the perception that the industry is inherently linked with environmental sustainability. Within the past 5 years, there has been a dramatic change in the stakeholder and corporate perception of sustainability. Increasing expectations from stakeholders are pressuring wind OEMs to transition and advance c
This paper aims to test the impact of a changing dimensional structure on the party system polarization for several countries in Western Europe. It will focus on research on why new parties, and in particular radical right parties, have been able to find ground in Europe. In particular, it will quantitatively test how this might correspond with an increase in the polarization of the new dimension
I Sverige finns en åldersgräns på 18 år för att ingå äktenskap men det finns ändå barn under 18 år i Sverige som är gifta. De gifta barnen har ingått barnäktenskap utomlands. Äktenskapen har erkänts som giltiga i Sverige om makarna saknade anknytning till Sverige när äktenskapen ingicks. Diskussioner har förts om att regleringen av erkännande av utländska barnäktenskap måste ändras för att skyddetThe age limit for getting married in Sweden is 18 years. Yet there are children under the age of 18 in Sweden who are married. The children have gotten married abroad. The marriages have been recognized as valid in Sweden if the spouses had no connection to Sweden when the marriages were entered. Discussions have been held about that the regulation of recognition of foreign child marriages needs t
In EU Competition Law, the addressee of the prohibition indicated in the Treaty on the Functioning of the European Union (TFEU) is the undertaking. The Court of Justice of the European Union (CJEU) has applied the notion of undertaking using an economic and functional approach, determining that undertaking, as a single economic entity, may consist with several separate legal entities, including na
