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Background: The L68Q variant of cystatin C is highly amyloidogenic forming aggregates in individuals with HCCAA. Results: Spermatozoa from mice expressing human L68Q cystatin C exhibit fertility defects and increased levels of amyloid. Conclusion: L68Q epididymal fluid containing cystatin C amyloid is harmful for sperm function. Significance: Amyloid in the reproductive tract may contribute to mal
The Narodichesky region, Zhitomir Oblast, Ukraine, is situated ∼80 km from the Chernobyl Nuclear Power Plant, which exploded in 1986 and polluted the environment. A previous study found that children living in villages with high activity of (137)Cesium (Cs) in the soil had decreased levels of hemoglobin, erythrocytes and thrombocytes. These findings motivated the present study that used a more com
Rapid economic development in the aftermath of the Chinese post-1978 reforms has resulted in a shrinking of grain grown area in the southern and eastern regions of the country which in turn is believed to have put the marginal northern regions under increased pressure. This paper examines key indicators of agricultural performance as well as cultivated land area development of the pre- and post-19
By regulating migration, proliferation and apoptosis as well as extracellular matrix synthesis and assembly, proteoglycans, integrins and the dystrophin-glycoprotein complex may be of great importance both during development and in vascular disease.
PURPOSE: To assess the risk of death in patients who survive more than 5 years after diagnosis of childhood cancer and to evaluate causes of death in fatal cases. PATIENTS AND METHODS: This was a population-based study in the five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) using data of the nationwide cancer registries and the cause-of-death registries. The study cohort inclu
J.S.Sneedorff joined patriotism and political theory in his treaty from 1757: "OnCivil Government". He was professor 'Juris publici et Politices' at the Academy in Sorø from 1751-1761. His successor at the Academy, Andreas Schytte, lectured during the years 1761-77 and published his political theory in eight volumes 1773-77.Together they represent a theory of monarchism and absolutism in Denmark-N
Biomechanical aspects are generally agreed to be significant, particularly during the planning of restorative treatments and the design of prosthetic appliances. However, comparative in vivo/in vitro studies show wide differences in the magnitudes and patterns of functional strains in prosthetic devices. The general aim of this study was to investigate some aspects of the biomechanical behavior of
Popular Abstract in Swedish Denna avhandling behandlar frågor om normbildning och argument för gemenskap i den svenska statsmaktens officiella retorik från 1660-1919. Varje nytt år skulle befolkningen i Sverige lyssna till de böndagsplakat som lästes upp i rikets kyrkor. Där informerades om riksdagar och gavs förklaringar till krig och kriser. Där beskrevs även grunden för rikets gemenskap och SveThis study deals with questions about norm building and arguments for community in official royal rhetoric in the Swedish realm from 1660 to 1919. Every year, an intercession day proclamation issued by the King in Council (Kungl. Maj:ts böndagsplakat) was read out from pulpits across Sweden. Like many communiqués, they belonged to the proclamation system, which included the spreading of informatio
Background: Autism spectrum disorders (ASD) are a group of severe childhood neurodevelopmental disorders with still unknown etiology. One of the most frequently reported associations is the presence of recurrent de novo or inherited microdeletions and microduplications on chromosome 16p11.2. The analysis of rare variations of 8 candidate genes among the 27 genes located in this region suggested SE
Background: To assess balance in single-limb stance, center of pressure movements can be registered by stabilometry with force platforms. This can be used for evaluation of injuries to the lower extremities. It is important to ensure that the assessment tools we use in the clinical setting and in research have minimal measurement error. Previous studies have shown that the ability to maintain stan
The aim of this study has been to identify, explain and delineate praying among peasant communities in the ecclesiastical province of Uppsala, Sweden. Four aspects have been examined through the perspectives of ideals and practices, namely the standards of prayer, devotional prayer, prayer in times of need and prayer cultures. The standards of prayer considered the physical and mental behaviour of
Background: The potential doubling time of a tumor has been suggested to be a measurement of tumor aggressiveness; therefore, it is of interest to find reliable methods to estimate this time. Because of variability in length of the various cell cycle phases, stochastic modeling of the cell cycle might be a suitable approach. Methods: The relative movement curve and the DNA synthesis time were esti
Objective No depression rating scale has yet been designed to identify all clinically important depressive states in elderly. Therefore, this study investigated the Hopkins Symptom Checklist-25 (HSCL-25), a self-rating scale for depression, to see if it was a sensitive indicator of major, minor and subsyndromal depression. Methods Structured interviews of 37 people with a high depressive score and
The antilipolytic effect of insulin on human abdominal subcutaneous adipose tissue and skeletal muscle during local inhibition of cAMP-phosphodiesterases (PDEs) was investigated in vivo, by combining microdialysis with a euglycaemic, hyperinsulinaemic clamp. During hyperinsulinaemia, the glycerol concentration decreased by 40% in fat and by 33% in muscle. Addition of the selective PDE3-inhibitor a
