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Bacterial ribosomes stalled on faulty, often truncated, mRNAs lacking stop codons are rescued by trans-translation. It relies on an RNA molecule (tmRNA) capable of replacing the faulty mRNA with its own open reading frame (ORF). Translation of tmRNA ORF results in the tagging of faulty protein for degradation and its release from the ribosome. We used single-particle cryo-electron microscopy to vi

Aneurysmal bone cyst (ABC) is a benign intraskeletal cyst that often expands rapidly and shows a strong tendency to recur. Rearrangement of chromosome band 17p13 is a characteristic genetic feature of ABC, with t(16;17)(q22;p13) the most frequent chromosomal aberration. This translocation generates a CDH11-USP6 fusion gene in which the strong promoter of osteoblast cadherin 11 gene at 16q22 is fus

Variation in exposure to sex hormones during early development contributes to phenotypic plasticity in vertebrate offspring. As a proposed marker for prenatal sex hormone exposure and because of their association with various physiological and behavioral characteristics, digit ratio and/or digit length have received notable interest within the field of evolutionary ecology. However, the validity o

Since the early 1990s, the European Union (EU) has presented itself as a leader on climate change. Recently, however, this picture has been challenged in the media and by non-governmental organization representatives. The aim of our article is to evaluate the Union's present role in the area of international climate politics. We do this by scrutinizing the EU's own role conception, but also, and p

Technical infrastructures of the society are becoming more and more interconnected and interdependent, i.e. the function of an infrastructure influences the function of other infrastructures. Disturbances in one infrastructure therefore often traverse to other dependent infrastructures and possibly even back to the infrastructure where the failure originated. It is becoming increasingly important

We study the Zeeman spin splitting in a quantum point contact (QPC) etched into an InGaAs/InP heterostructure for three orthogonal magnetic field orientations with respect to the QPC. For the two in-plane orientations we observe an isotropic Zeeman spin splitting, which becomes stronger as the system is made more one dimensional. The Lande g factor is enhanced by up to a factor of two compared to

There appears to be an increasing interest within library and information studies (LIS) in so-called indigenous or traditional knowledge. Discussions on usefulness and applicability of indigenous knowledge in development seem to be motivating electronic documentation and the creation of databases. Often, definitions provided by international organisations are drawn on unquestioningly, while power

The repair and maintenance of electrical power lines involves awkward postures, which are known risk factors for developing musculoskeletal disorders. The aim of the present study was to quantify postures and movements of upper arm, head, upper back and neck in the main tasks performed by line workers. Posture of twelve right-handed line workers was recorded by inclinometry and presented as percen

The position generator is a widespread method for measuring latent social capital in which respondents are queried about contacts on a list of occupations predefined by the analyst. We separate out the unique contribution of each occupation to aggregated measures of social capital. It turns out that this contribution varies vastly: knowing a person in some occupations provides substance to measure

Mounting evidence from proxy records suggests that variations in solar activity have played a significant role in triggering past climate changes. However, the mechanisms for sun-climate links remain a topic of debate. Here we present a high-resolution summer sea-surface temperature (SST) record covering the past 9300 yr from a site located at the present-day boundary between polar and Atlantic su

It is a hallmark of natural language use that the way we talk about something reflects how it is represented in the mind of our conversation partner. This thesis studies the use and cognitive processing of referring expressions like one in comparison with other expression types in spoken Danish. The cognitive status of referents in other people’s minds can be understood in terms or referential g

Popular Abstract in Swedish På apoteket hittar vi den ena burken efter den andra med olika sorters smärtstillande medicin. Hur många av dessa är verkligen effektiva mot ihållande och svår smärta? Många receptbelagda läkemedel som lindrar smärta förändrar samtidigt vårt beteende, till exempel vår förmåga att fatta beslut. De kan dessutom också orsaka slöhet och onormal koordination. För att kunnaCurrent models of pain in conscious animals usually scores nocifensive responses. However, it is still unclear to what extent these responses are related to, for instance, the sensory discriminative or affective aspects of pain. This touches upon an intriguing question on how the nervous system processes nociceptive information in the conscious brain, a matter of which little is known. In order to

Several coastal areas in the south of Sweden are subjected to flooding and erosion. Such events depend on the magnitude and frequency of water levels and wave heights as well as their joint occurrence. Long time series of climate data from the south coast of Sweden were employed to investigate the statistical properties of extreme events in terms of the waves and water level changes. Through the c

Melangyna pavlovskyi (Violovitsh, 1956) has been found breeding in Denmark. The species is recorded from four localities on Zealand, and it is established on at least one of these. It is new to the European fauna. A redescription of M. pavlovskyi based on the external characters and an updated key to the NW European species of Melangyna are presented.

Purpose: To study pharmacokinetics of levetiracetam (LEV) during pregnancy, delivery, lactation, and in the neonatal period. Methods: Fourteen women with epilepsy receiving LEV treatment during pregnancy and lactation contributed with 15 pregnancies to this prospective study in which LEV concentrations in plasma and breast milk were determined. Trough maternal plasma samples were collected each tr