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New neurons are only generated in two places of the postnatal brain; the subventricular zone (SVZ) and hippocampus. The SVZ-derived cells specifically migrate to the olfactory bulb where they give rise to new interneurons. We have genetically manipulated the postnatal SVZ progenitor cells with the aim to direct them to a neuronal fate in the striatum. Our result showed that ectopic expression of t
Popular Abstract in Swedish Protein kinas C (PKC) är en familj serin/treonin kinaser som har en viktig roll i regleringen av olika funktioner i cellen. PKC kan delas in i klassiska (alpha, betaI, betaII and gamma), nya (delta, epsilon, eta and theta) och atypiska (zeta and iota/lambda) isoformer beroende på skillnader i hur de regleras. När PKCalpha är inaktivt bidrar intramolekylära bindningar tiMembers of the protein kinase C (PKC) family of serine/threonine kinases play critical roles in cellular regulation. Depending on differences in regulation, PKCs can be divided into classical (alpha, betaI, betaII and gamma), novel (delta, epsilon, eta and theta) and atypical (zeta and iota/lambda) isoforms. When PKCalpha is inactive it is maintained in a closed conformation by intramolecular inte
New trilobite discoveries from eight localities in Vastergotland, south-central Sweden, demonstrate that the middle Cambrian Ptychagnostus punctuosus and Goniagnostus nathorsti zones are present in most Lower Palaeozoic outcrop areas of Vastergotland, though as a thin and impersistent conglomeratic limestone, up to approximately 15 cm thick. These zones have not previously been recognised in Vaste
Objective-In clinical islet transplantation, the instant blood-mediated inflammatory reaction (IBMIR) is a major factor contributing to the poor initial engraftment of the islets. This reaction is triggered by tissue factor and monocyte chemoattractant protein (MCP)-1, expressed by the transplanted pancreatic islets when the islets come in contact with blood in the portal vein. All currently ident
In a prospective study of a consecutive breast cancer series accumulated in the period 1978-82, the S-phase fraction (SPF) and ploidy status were determined by flow cytometry performed on cell nuclei derived from samples of 580 primary tumors. Sixty percent of the tumors were non-diploid. After correction for debris the median SPF values were 7.3% overall, 12% for non-diploid tumors, and 2.9% for
Model studies of photosynthetic carbohydrate formation in the chloroplast of C3 plants have been performed to examine the expected response of the steady-state reaction flux to finite changes in concentration or activity of individual enzymes in a central metabolic network. The results indicate that flux control coefficients in this system cannot be reliably estimated experimentally even for the t
Limitations of the pulse-shape discrimination (PSD) technique - a promising method to identify the charged particles stopped in planar Si-detectors - have been investigated. The particle resolution turned out to be basically determined by resistivity fluctuations in the bulk silicon which cause the charge-collection time to depend on the point of impact. Detector maps showing these fluctuations ha
The bicyclic keto-alcohol (1S,4R,6S)-bicyclo[2.2.2]octan-6-ol-2-one, (+)-3, self-assembles in the solid state through hydrogen bonds between the alcohol and the carbonyl groups creating supramolecular helices, without the aid of other forces such as pi-pi interactions to stabilise the superstructure. Furthermore, the bicyclic compound (4) although structurally quite different, in relation to (+)-3
I formulate a simple model of the ultimatum game, in which a proposer and a responder can receive a reward if they agree on how to divide this reward between them. The model is easy to analyse and shows that strong tendencies to fair division are expected when evolution of strategy frequencies follow the traditional gradient dynamics assumed in evolutionary models. The mean stable offer is typical
Levosimendan is a new agent for the treatment of acute heart failure. Levosimendan acts via complementary mechanisms; it enhances contractility by sensitising cardiac myofilaments to calcium and dilates blood vessels by opening ATP-dependent potassium channels. In contrast to traditional inotropes (beta-agonists or phosphodiesterase inhibitors), levosimendan does not raise myocyte calcium levels a
Background The endothelial ADP receptor P2Y(1) is responsible for a large part of the reactive hyperemia following cardiac ischemia. Tissue plasminogen activator (t-PA) increases during reactive hyperemia. We postulated that the release of t-PA during reactive hyperemia could be mitigated through blocking the coronary endothelial P2Y(1) receptor. Methods t-PA was measured in peripheral arterial bl
Windows in a package is a common way to promote the product. The possibility to predict the collapse load for these types of cartonboard packages is considered. It is shown that reliable estimates of the collapse loads can be obtained by a very simple approach. This approach is a straightforward generalization of the proposal by Ristinmaa et al. (2012): for a side that contains a window, one simpl
This special section of an issue of Science and Public Policy grew out of an interest in following the politics of the European Spallation Source (ESS) Facility at Lund, Sweden. The ESS spectacle provided a platform from which to review different research infrastructure projects and to place them in the context of science policy as a whole. Large-scale research infrastructure investments are often
The absorption, tissue distribution and excretion of enteral alpha-ketoglutarate (AKG) was studied in four experiments. Six male Sprague Dawley rats were used to investigate the excretion of AKG in urine and faeces. Thirty rats, randomly assigned to five groups, were used to investigate the distribution of AKG in body tissues. They were gavaged with AKG enriched with 3 muCi/kg BW of (14)C uniforml
The nomenclature of Gallowayella, Golubkovaea, Oxneria, and some species of Gyalolechia, Leproplaca, and Rusavskia in the Teloschistaceae is corrected and commented. Rusavskia ectaniza is a new combination. Also the earlier invalidly published combinations Gyalolechia bassiae, Leproplaca chrysodeta, and Rusavskia aspera are validated.
In this article I present the motivation for introducing the invariant functions of mass matrices, based on my own work, and give some examples. Since their introduction in 1985, in the framework of the Standard Electroweak Model, they have been used by many authors. Some authors have gone further along this path and have studied the extensions of this concept to frameworks beyond the Standard Mod
Monitoring of permafrost has been ongoing since 1978 in the Abisko area, northernmost Sweden, when measurements of active layer thickness started. In 1980, boreholes were drilled in three mires in the area to record permafrost temperatures. Recordings were made twice per year, and the last data were obtained in 2002. During the International Polar Year (2007-2008), new boreholes were drilled withi
