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The cysteinyl-leukotrienes (cysLTs: LTC4, LTD4 and LTE4) have an important pathophysiological role in asthma. They are not only extremely potent bronchoconstrictors, but are also involved in the central mechanisms of the asthmatic inflammation and the subsequent remodelling of the airways. Allergen-induced bronchoconstriction as well as spontaneous exacerbations of asthma are associated with incre
The goal of this paper is to discuss current problems of education for sustainable development, i.e. a global educational innovation that is actively growing in the new century. In Sweden, which has extensive experience in ecological education, education for sustainable development is considered a national model for the creation of the foundation for SD. In Russia, difficulties exist in defining a
Binding of platelet-derived growth factor (PDGF) to its receptors leads to the activation of members of the Src family of protein tyrosine kinases. We show here that Fyn, a member of the Src family, is phosphorylated on Tyr28 in the unique N-terminal part of the molecule after interaction with the intracellular domain of the PDGF beta-receptor. Activated Fyn furthermore undergoes autophosphorylati
Elevated plasma cytokines is a common finding in Major Depressive Disorder (MDD), although not consistent. It is currently not known whether the inflammatory changes are confined to any specific subgroup of depressive patients. We here analyzed three inflammatory markers in suicidal and non-suicidal depressive patients, as well as healthy controls. Plasma interleukin (IL)-2, IL-6 and tumor necrosi
Research study was conducted from January to May, 2002 in residential areas along the Palosi Drain, Peshawar. Main objective of the study was to evaluate water quality of shallow and deep wells in the vicinity of Palosi Drain. For this purpose, 20 water samples were taken 13 from shallow wells, 3 from deep wells and 4 from wastewater in the Palosi Drain. Water samples were analyzed for heavy metal
OBJECTIVE:: To evaluate the effect of prednisolone and valacyclovir on ipsilateral pain around the ear and in the face or neck in Bell's palsy. The incidence and intensity of pain during the first 2 months of palsy and its prognostic value were also assessed. STUDY DESIGN:: Prospective, randomized, double-blind, placebo-controlled, multicenter trial. SETTING:: Sixteen tertiary referral centers in
Uncoupling protein 2 (UCP2) is upregulated in the brain after sublethal ischemia, and overexpression of UCP2 is neuroprotective in several models of neurodegenerative disease. We investigated if increased levels of UCP2 diminished neuronal damage after global brain ischemia by subjecting mice overexpressing UCP2 (UCP2/3tg) and wild-type littermates (wt) to a 12-min global ischemia. The histopathol
Diabetic kidney disease is the leading cause of end-stage renal disease. Genetic factors have been suggested to contribute to its susceptibility. However, results from genetic studies are disappointing possibly because the role of glucose in diabetic kidney disease predisposed by epigenetic mechanisms has not been taken into account. Since thioredoxin-interacting protein (TXNIP) has been shown to
This paper focuses on the grammatical expression or ‘packaging’ of modality in Japanese. I consider two aspects: (1) the grammatical encoding of epistemic, deontic, and evidential notions with English as a point of comparison, and (2) the co-encoding of modality and subjectivity. As for the former aspect, the comparison between Japanese and English exemplifies how languages can take different stra
Abstract> Objectives. Diagnostics of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) are complex, and based on the 2010 Task Force document including different diagnostic modalities. However, recommendations for clinical management and follow-up of patients with ARVC and their relatives are sparse. This paper aims to give a practical overview of management strategies, risk str
The function of chronic brain machine interfaces depends on stable electrical contact between neurons and electrodes. A key step in the development of interfaces is therefore to identify implant configurations that minimize adverse long-term tissue reactions. To this end, we here characterized the separate and combined effects of implant size and fixation mode at 6 and 12 weeks post implantation i
To reach its large computing needs, the ALICE experiment at CERN has developed its own middleware called AliEn, centralised and relying on pilot jobs. One of its strength is the automatic installation of the required packages. The Nordic countries have offered a distributed Tier-1 centre for the CERN experiments, where the job management should be done with the NorduGrid middleware ARC. We have de
Katekeser är en genre som vanligtvis förknippas med lutheransk religionsundervisning, och inte revolutioner. Dess form, att ställa en antal givna frågor och ge ett definitivt svar för varje fråga synes lämna föga utrymme för självständigt och kritiskt tänkande. Frågandet som teknik är en retorik; syftet är att styra läsarens tänkande i avsedd riktning. Inpräntande av normer, inte radikala reflekti
The HASTA indicator framework, covering the three dimensions of sustainability, i.e. Economic, Environmental and Social, to monitor sustainability of transport in Swedish cities was elaborated. Under the three sustainability dimensions, there are 6 sustainability aspects (indicator groups), 2-3 per dimension; these are Efficiency, Accessibility (Economic dimension), Accessibility, Safety, Liveabil
Popular Abstract in Swedish Den kroniska inflammation som ses hos personer med inflammatorisk tarmsjukdom är troligen en immunologisk reaktion riktad mot normala tarmbakterier. I denna process har monocyter/makrofager (särskild celltyp av vita blodkroppar) en central betydelse. Det är huvudsakligen makrofager i tarmslemhinnan som styr det immunsvar som utvecklas då tarmfloran kommer i kontakt med Inflammatory bowel disease is thought to result from the inappropriate and ongoing activation of the mucosal immune system driven by the presence of normal luminal flora. In this process monocytes/macrophages contribute to and maintain chronic inflammation by being both regulatory and effector cells. This study aimed at exploring the effects and regulation of chronic inflammation in inflammatory
