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Methyl 2-O-acetyl-3-benzotriazolo-4,6-O-benzylidene-3-deoxy- β -D-galactopyranoside was assembled by reacting benzyne, from 2-trimethylsilyl-trifluoromethansulfonylbenzene, and a secondary galactopyranoside azide in a copper-free Huisgen 1,3-dipolar cycloaddition. Following deprotection, the resulting benzotriazoles were evaluated as galectin inhibitors resulting in a 2-4 fold increase in affinity

This book analyzes experiences of and possibilities for developing countries to catch up by providing a set of analytical interpretations of development experiences that with different degrees of success have taken place in Asia, Latin America, and sub-Saharan Africa. Based on the growth performance across the developing world over the last decades, it offers thorough accounts of the possibilities

This thesis is focused on the early steps of a complex virus-cell interaction. The human adenovirus type 2 (HAdV-2) infects permissive cells, by first recognizing a protein of the immunoglobulin superfamily that serves as the Coxsackie and adenovirus receptor (CAR). This attachment step is mediated by the adenovirus fiber protein. Subsequently, in order to proceed to a tighter binding, the viral p

Bohemia and Moravia, today part of the Czech Republic, was the first territory with a majority of non-German speakers occupied by Hitler’s Third Reich on the eve of the World War II. Tens of thousands of Jewish inhabitants in the so called Protectorate of Bohemia and Moravia soon felt the tragic consequences of Nazi racial politics. Not all Czechs, however, remained passive bystanders during the g

This dissertation is a contribution to the debate about ‘climate justice’, i.e. a call for a just and feasible distribution of responsibility for addressing climate change. The main argument is a proposal for a cautious, practicable, and necessary step in the right direction: given the set of theoretical and practical obstacles to climate justice, we must begin by making contemporary development p

Today one could argue that most of the logistics research available has a strong connection to the positivistic paradigm where there is a great emphasis on simplicity in both the research conducted and in the solutions produced. The overall ability to design, plan and control is promoted by the researchers to a great extent. Consequently, firms invest money, time and resources in solutions, based

In stochastic time-frequency analysis, the covariance function is often estimated from only one observed realization with the use of a kernel function. For processes in continuous time, this can equivalently be done in the ambiguity domain, with the advantage that the mean square error optimal ambiguity kernel can be computed. For processes in discrete time, several ambiguity domain definitions ha