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The adipocyte-derived hormone leptin is associated with insulin resistance and reduced fibrinolytic status - or dysfibrinolysis - in humans. As leptin associates differentially to the development of cardiovascular disease and diabetes in men and women, we hypothesized that leptin and insulin sensitivity are related to dysfibrinolysis in a sex-dependent manner. Thirty-two men and 40 women were recr
We study the ground state of the Pauli Hamiltonian with a magnetic field in R2d,d>1. We consider the case where a scalar potential W is present and the magnetic field B is given by B=2i ∂̄∂W. The main result is that there are no zero modes if the magnetic field decays faster than quadratically at infinity. If the magnetic field decays quadratically then zero modes may appear, and we give a lower b
OBJECTIVE: To investigate the ability of statins to activate the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) in primary human monocytes in culture. MATERIALS AND METHODS: Human peripheral monocytes were incubated with atorvastatin (0.1-10 micromol/1) for up to 24 hours. PPAR-gamma expression was analysed by electrophoretic mobility shift assay. Pro-inflammatory c
While Huntington's disease (HD) is a condition that primarily involves the basal ganglia, there is evidence to suggest that the hypothalamus is also affected. Because the osmoreceptors regulating thirst are situated in the circumventricular region of the hypothalamus, we were interested in whether altered thirst is a part of the HD phenotype. We used the LABORAS behavioural monitoring system and w
Phonology has been a central concept in the scientific study of dyslexia over the past decades. Despite its central position, however, it is a concept with no precise definition or status. The present article investigates the notion of 'phonology' in the tradition of cognitive psychology. An attempt is made to characterize the basic assumptions of the phonological approach to dyslexia and to evalu
Developmental instability and fluctuating asymmetry (FA) describe the inability of organisms to correct for random accidents under development and has become a major but controversial topic in evolutionary biology. Theoretical models predict that the level of FA should increase as a result of inbreeding, but empirical results are ambiguous. Moreover, the relationship between fitness and FA is stil
Droplet sizes of oil/water (O/W) nanoemulsions prepared by the phase inversion temperature (PIT) method, in the water/C16E6/mineral oil system, have been compared with those given by a theoretical droplet model, which predicts a minimum droplet size. The results show that, when the phase inversion was started from either a single-phase microemulsion (D) or a two-phase W+D equilibrium, the resultin
In this article, we evaluate the work out of some artificial neural network models as tools for support in the medical diagnosis of urological dysfunctions. We develop two types of unsupervised and one supervised neural network. This scheme is meant to help the urologists in obtaining a diagnosis for complex multi-variable diseases and to reduce painful and costly medical treatments since neurolog
The viscoelastic behavior of the two different liquid crystalline lamellar phases and the liquid crystalline cubic phase of the mixed soybean lecithin/DDAB system in water was studied through rheology, with mechanical parameters studied as a function of composition. The swollen or diluted lamellar region is formed by vesicles, and its characteristic flow curve presents two-power law regions separa
To investigate if polyomavirus infection during pregnancy is linked to development of neuroblastoma in the child, serum samples of 115 index mothers from the pregnancy where the child eventually developed neuroblastoma were identified and matched with serum samples from 8 control mothers per index mother. The samples were tested for. specific IgG and IgM antibodies to BK and JC virus using enzyme
Species of the Botanophila helviana species group are small, blackish anthomyiids known from temperate to subarctic (northern/elevated) parts of the Holarctic Region. Adult flies are anthophilous, obtaining pollen and nectar from various flowering plants. Preliminary evidence suggests that the larvae may attack developing seed heads of Ranunculus (Ranunculaceae). The male and female terminalia are
OBJECTIVE: The aim of this study was to delineate electrocardiogram (ECG) patterns in postmenopausal women with hypercholesterolemia and to assess the possible influence of female sex hormones. STUDY DESIGN: A total of 72 postmenopausal women with moderately elevated total cholesterol levels constituted the case group, of which 48 came from a clinical trial and 24 from a cohort study. Some 236 wom
Evolutionary change results from selection acting on genetic variation. For migration to be successful, many different aspects of an animal's physiology and behaviour need to function in a co-coordinated way. Changes in one migratory trait are therefore likely to be accompanied by changes in other migratory and life-history traits. At present, we have some knowledge of the pressures that operate a
Overexpression of human alpha-synuclein (alpha-syn) using recombinant adeno-associated viral (rAAV) vectors provides a novel tool to study neurodegenerative processes seen in Parkinson's disease and other synucleinopathies. We used a pseudotyped rAAV2/5 vector to express human wild-type (wt) alpha-syn, A53T mutated alpha-syn, or the green fluorescent protein (GFP) in the primate ventral midbrain.
Type 1 fimbriae have been implicated as virulence factors in animal models of urinary tract infection (UTI), but the function in human disease remains unclear. This study used a human challenge model to examine if type 1 fimbriae trigger inflammation in the urinary tract. The asymptomatic bacteriuria strain Escherichia coli 83972, which fails to express type 1 fimbriae, due to a 4.25 kb fimB-fimD
The dynamic vegetation model (LPJ-GUESS) is used to project transient impacts of changes in climate on vegetation of the Barents Region. We incorporate additional plant functional types, i.e. shrubs and defined different types of open ground vegetation, to improve the representation of arctic vegetation in the global model. We use future climate projections as well as control climate data for 1981
