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Purpose: Identifying biomarkers of radiotherapy (RT) response is important for optimizing the treatment of early breast cancer. In this study, we tested the interaction between endothelial cell (EC) expression of phospho-Tyr397-FAK (pY397-FAK) and adjuvant-RT on clinical outcomes after breast-conserving surgery (BCS) within a randomized study. Preclinical data suggest an enhanced effect of RT on l
Fine-grained windblown deposits, known as loess, in which fossil soils (palaeosols) are preserved, serve as excellent records of past climate. However, paleoclimate reconstruction studies on loess-palaeosol sequences (LPS) in Southeastern Europe have primarily focused on climate changes during the last one or two glacial-interglacial cycles. Surprisingly, little attention has been given to the cli
We use the introduction of covered bonds in Norway in 2007 together with administrative and supervisory data at the bank and loan level to investigate the effect of asset encumbrance, that is, pledging assets as collateral, on the composition of bank balance sheets and bank risk. We show that covered bonds—despite being collateralized with mortgages—lead to a shift in bank lending from mortgages t
When language learning takes place post-migration, the challenge is not only to attain fluency. Learning is tied up with life opportunities and is overshadowed by hopes and fears for the future. In the post-migration phase, hopeful thinking can support the acculturation process. Hope is a goal-related construct that captures variation in adaptability in the pursuit of positive outcomes. It involve
Universities worldwide have increased their competition for the best students and employees. Consequently, business schools are pressured to demonstrate excellence and differentiate themselves through brand building. One essential part of branding is the quality narratives that universities present to the public. We study the presentation of quality in Nordic business schools. Data concerning the
The eighteenth century marks a watershed in European intellectual history. It witnessed the development of many civil rights ideas that were prerequisites for the emergence of modern political systems. One principle that appears to be supported by numerous empirical examples is that evolving political pluralism fostered the right to express one’s views with a certain degree of freedom. This articl
Bovine mastitis is a continuous problem in the dairy industry. The infection has significant impact on health and welfare of animals and causes financial losses for the farmers and the dairy industry. A key bacterium associated with bovine mastitis is Staphylococcus aureus (S. aureus). It produces different exotoxins including more than 24 different staphylococcal enterotoxins and toxic shock synd
In 2003, the Swedish Municipal Workers’ Union (Kommunal) called a nationwide strike, demanding a pay rise for all members in the public sector. Drawing on oral history interviews with workplace representatives and local union officials, the article examines how the struggle enabled changes in subjectivity, generating utopian visions for increased visibility and agency for municipal workers. This p
Work and working conditions are fundamental social determinants of health. Climate change poses an urgent and growing threat to workers' health, through both direct exposure to environmental hazards and indirect exacerbation of social and health inequalities. Occupational health, which focusses on the promotion of mental and physical health and well-being of workers, is a key but often overlooked
In this work, we have studied how the choice of the continuous phase oils affects droplet-internal acoustic manipulation and mapped the acoustic properties of the selected oils to evaluate their compatibility with droplet acoustofluidic methods. The selection of continuous phase included hydrocarbon, fluorinated, and silicone oils. To map the acoustic properties of the oils, we measured their spee
Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. The cystine/glutamate antiporter, system xc-, is one of the >200 cytoprotective proteins controlled by NRF2, which can be non-invasively imaged by (S)-4-(3-18F-fluoropropyl)-l-glutamate ([18F]FSPG) positron emission tomography (PET). Throu
Abstract: The biliary excretion of the vasopressin analogue 1‐deamino‐8‐D‐arginine vasopressin (dDAVP) was determined in the pig after three administration routes, intrajugular venous, intraportal venous and intraduodenal. In all cases the biliary excretion was less than 1% of the administered dose. The plasma/bile concentration ratio was less than 1:1. A significant first‐pass effect was found w
This paper stems from an inductive research problem: the support given to the military-deep state by the youth revolutionary movement in Egypt’s political upheavals of summer 2013. Why would the youth revolutionary movement choose to support the military-deep state’s political maneuverings, and what is the precise nature of this support? To answer these questions, this paper chooses to explore two
Paper presented at Swedish Anthropological Association Annual Meeting, Lund, April 2015, panel on Business ethics. Abstract: Under the influence of U.S. government regulations, new anti-bribery laws and embarrassing corruption scandals, major global corporations have realized that unethical conduct may affect their reputations and ultimately, their profits. This development has given rise to a new
When discussing choice of methodology in evaluation studies, it is wise to reflect upon organizational considerations concerning contracting, conducting and utilization. Based upon research conducted among social workers in Sweden this paper focuses upon possibilities and problems in knowledge dissemination and usage. Powerful institutions in Sweden are now encouraging knowledge development of soc
