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Objectives: Decision-analytic models assessing the value of emerging Alzheimer's disease (AD) treatments are challenged by limited evidence on short-term trial outcomes and uncertainty in extrapolating long-term patient-relevant outcomes. To improve understanding and foster transparency and credibility in modeling methods, we cross-compared AD decision models in a hypothetical context of disease-m
Objectives: The enormous burden that cardiovascular diseases put on individuals and societies warrants reliable biomarkers of disease risk to optimize disease prevention. We studied longitudinal movement (LMov) in arterial walls using ultrasound of the common carotid artery (CCA). We believe that LMov could be a sensitive biomarker of cardiovascular health and in this study, we evaluate the intra-
Background: Two risk factors for severe retinopathy of prematurity (ROP) in extremely preterm infants are thrombocytopenia and low levels of arachidonic acid (AA) and docosahexaenoic acid (DHA). To date, these risk factors have not been linked. Method: Infants born < 28 weeks gestational age (GA) from 2016 to 2019 were randomized to postnatal enteral AA/DHA supplementation or standard care (contro
Background: Although glomerular diseases are the third most frequent cause of end-stage kidney disease worldwide, little is known about their long-term outcomes. Methods: In patients with chronic kidney disease (CKD) stage 3–5 enrolled in the Swedish Renal Registry, we compared risks of hospitalization, kidney replacement therapy (KRT), major cardiovascular events (MACE), and death of the four mos
Background/Objectives: The surgeon’s subjective intraoperative evaluation is the standard of care to assess postoperative residual disease (RD) in advanced epithelial ovarian cancer (EOC). We investigated the feasibility of ctDNA as an objective marker for postoperative RD. Methods: This prospective study included 27 patients with advanced ovarian cancer (FIGO IIIA1–IVB) who underwent primary surg
BACKGROUND: The efficacy of corticosteroids for treating acute vestibular neuritis, or acute unilateral vestibulopathy (AUVP), remains controversial.OBJECTIVE: This study aimed to evaluate whether corticosteroids improve vestibular function and reduce symptoms in both acute and chronic phases of AUVP.METHODS: This randomized, placebo-controlled, double-blind trial included patients with AUVP (ages
Familial Platelet Disorder with associated Myeloid Malignancy (FPDMM, FPD/AML, RUNX1-FPD), caused by monoallelic deleterious germline RUNX1 variants, is characterized by bleeding diathesis and predisposition for hematologic malignancies, particularly myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Clinical data on FPDMM-associated AML (FPDMM-AML) are limited, complicating evidence
Background and Objectives: Temporomandibular disorders (TMDs) is an umbrella term for pain and dysfunction involving jaw muscles and/or the temporomandibular joint, with whiplash trauma suggested to be one risk factor. The aim was to evaluate prevalence and relative risk of TMDs in the acute and chronic stages after whiplash trauma. Databases and Data Treatment: This review was registered in Prosp
Cubosomes are non-lamellar lipid nanoparticles that have drawn a significant attention in the field of nanomedicine due to their tunable properties. However, the formation of vesicles during the preparation of cubosomes, and the presence of mixed bicontinuous cubic phases, may lead to artifacts and lack of correlation between the physico-chemical and biological characterization. In this work, we h
Enantioselective synthesis is an important research topic with applications in drug development. Asymmetrical catalysis is one of the available ways of producing enantioenriched products. C2-Symmetric dibenzo[a,e]cyclooctenes or dbCOTs are a family of versatile chiral ligands for transition metals. They display great efficiency and enantioselectivity in 1,2- and 1,4- additions reactions. In this
Background: The effects on left and right ventricular (LV, RV) volumes during physical exercise remains controversial. Furthermore, no previous study has investigated the effects of exercise on longitudinal contribution to stroke volume (SV) and the outer volume variation of the heart. The aim of this study was to determine if LV, RV and total heart volumes (THV) as well as cardiac pumping mechani
Older and normally more low-scale buildings are from a historical and cultural perspective in need to be preserved. But these older buildings are often also perceived as contributing to more beauty-oriented values to an urban environment, so called charm. For these reasons, new building development projects should be designed in such a way that these qualities are not destroyed. This study has thr
The final purpose of this project is to create a platform that leads to the improvement of the braking feeling by the users of heavy vehicles. The complexity of the problem lays on the different constraints: geometrical and functional, and as well on the interaction with a human operator. The task is to design a new electronic brake pedal, with the possibility to change the relationship between fo
Objective To investigate the admission rate to neonatal care and neonatal morbidity after maternal use of antipsychotics during pregnancy. Design A population-based register study. Setting Information on all singleton births between July 2006 and December 2017 in Sweden including data on prescription drugs, deliveries and infants' health was obtained from the Swedish Medical Birth Register, the Pr
The Great Rift Valley running through Eastern Africa contains a large number of soda lakes. These unique lakes constitute among the most stable alkaline environments with a dense and varied population of microorganisms. Such microorganisms are invariable alkaliphiles and are considered to be a promising source of enzymes with unique features. Some enzymes produced by alkaliphilic microorganisms ha
Popular Abstract in Swedish Denna avhandling behandlar design, tillverkning, karakterisering och optimering av elektroniska komponenter alla baserade på kvantmekanisk tunnling. Tunnling är ett rent kvantmekaniskt fenomen utan någon klassisk motsvarighet, som först blir relevant då dimensionerna krymper ner i nanometerskala (en nanometer är en miljarddel's meter). Då kan elektroner ”tunnla” igenomThis thesis concerns different kinds of tunneling based devices all showing negative differential resistance. The thesis is divided in three parts, resonant tunneling transistors, Esaki diodes and coupled zero dimensional systems. The resonant tunneling transistors are GaAs-based vertical field effects transistors, based on a combination of overgrown tungsten gates and double barrier heterostruct
Abstract is not available.
Ansvar är ett ord som både praktiker och forskare ofta använder. Det är ett centralt begrepp i organisatoriska sammanhang. Innebörden av begreppet är dock oftast för givet tagen.Om ansvar diskuterar betydelsen av för-givet-tagna begrepp och reflekterar över ansvarsbegreppets innebörd utifrån en granskning av såväl företagsekonomisk teori som praktik. De frågor som inledningsvis ställs är vilken inBased on an ethnographic study, the dissertation discusses the concept of "responsibility" in the context of what happened when workers were made responsible for an area of their own. It turned out that "being responsible", was related to a narrative identity that differed from the one they used before they were made formally responsible. For most of the workers, the narrative of being "responsibl
