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A method is suggested which allows truncation of the virtual space in Cholesky decomposition-based multiconfigurational perturbation theory (CD-CASPT2) calculations with systematic improvability of the results. The method is based on a modified version of the frozen natural orbital (FNO) approach used in coupled cluster theory. The idea is to exploit the near-linear dependence among the eigenvecto
Cerebrovascular disease may be linked with vascular autoregulation in aging. The aim of this study was to examine relation between nocturnal blood pressure (BP) fall and cerebral blood flow (CBF) changes in elderly men. The prospective 'Men born in 1914' cohort study has been in progress since 1968 and included 809 subjects. After 14 years from the last follow up, 97 subjects reached the age of 82
We have investigated the lipid chemistry during cold acclimation in the freeze tolerant earthworm Dendrobaena octaedra. The dominant phospholipid fatty acids (PLFA) of D. octaedra were 20:4, 20:5 and 20:1 (50% of total PLFA) followed by 18:0, 18:1 and 18:2 omega 6,9 (25% of total PLFA). The ability to tolerate freezing in this species was acquired after acclimation at low temperature for 2-4 weeks
We have used proton magnetic relaxation dispersion (MRD) to study the self-association of bovine ß-lactoglobulin variant A (BLG-A) as a function of temperature at pH 4.7 (dimer–octamer equilibrium) and as a function of NaCl concentration at pH 2.5 (monomer–dimer equilibrium). The MRD method identifies coexisting oligomers from their rotational correlation times and determines their relative popula
Because of its simplicity the rational method is still frequently used in urban planning and design. In this paper using the time-area method and statistically derived design storms, the design peak flow is computed for urban basins of different complexity and compared with the design flow determined from the rational method. It is shown that the design flow is underestimated using the rational me
Three primary hypotheses currently prevail for correlations between heterozygosity at a set of molecular markers and fitness in natural populations. First, multilocus heterozygosity- fitness correlations might result from selection acting directly on the scored loci, such as at particular allozyme loci. Second, significant levels of linkage disequilibrium, as in recently bottlenecked-and-expanded
The secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. The presence of SLPI in renal tubuli cells was demonstrated using immunohistochemistry and, by means
Musculoskeletal problems are very common, and clinical assessment is central to their appropriate management; however, many clinicians are not sufficiently competent to carry out this assessment. A standardized approach to the clinical assessment of a musculoskeletal problem is, therefore, necessary, whether the patient is presenting to primary care, rheumatology or orthopedics. Such a standardize
An increasing number of studies describe moving hybrid zones. This raises the issue of their actual frequency and emphasizes the need for methods that enable the detection of zone movements without historical records. Asymmetric introgression, usually considered as a signature of geographical shift, might be misleading when applied to mitochondrial or potentially non-neutral markers. We investigat
The last thirty years have witnessed increasing diversity in methodology and perspectives within biblical studies. One of the most dynamic and continually expanding contributions to this development is that of postcolonial studies, known for its fresh approaches as well as for its complex theoretical foundations. The present book aims at introducing both student and scholar to this emerging field.
The chapter contains an analysis of two similar attempts to institutionalise ‘national memory’ in the Czech Republic and Slovakia after the fall of Communism and dissolution of Czechoslovakia. The study focuses on two documents that create a legal basis for such institutionalisation and on the main actors who initiated the decisions to create these institutes. It is argued that although the origin
The article analyses in a historical perspective how ideas of Europe are discussed in Baltic intellectual, political and scholarly debates, and how the Baltic republics are positioned in these debates.
The nature of innovation is changing. An increasingly globalized society, enabled by information and communication technologies (ICT), has changed the process of value creation and shifted the balance of power between firms and individual consumers – or users. Companies can no longer rely solely on operational efficiency or technological superiority in order to create a competitive advantage. Tod
Kaposi's sarcoma-associated herpes virus (KSHV) encodes a complement inhibitor named KSHV complement control protein (KCP). We have previously shown that KCP inhibits the human complement system by disrupting the C3 convertase of complement. KCP can accelerate the decay of the classical C3 convertase and it can act as a cofactor for factor I (R), which then cleaves and inactivates C4b or C3b (in t
