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Lentivirus-based vectors derived from human immunodeficiency viruses type 1 and 2 (HIV-1 and 2) are widely used tools in research and may also be utilized in clinical settings. Like their parental virions, they are known to depend on the cellular machinery for successful gene delivery and integration. While most of the studies on cellular proteomic and transcriptomic changes have focused on the la
Recent clinical trials of mesenchymal stromal cell (MSC) therapy for various inflammatory conditions have highlighted the significant benefit to patients who respond to MSC administration. Thus, there is strong interest in investigating MSC therapy in acute inflammatory lung conditions, such as acute respiratory distress syndrome (ARDS). Unfortunately, not all patients respond, and evidence now su
A growing literature illuminates the limits of claims made on the basis of sensory perception in scientized, rationalized, and bureaucratic contexts. How to understand exceptions to the rule – cases where claims based on sensory experience are taken at face value, even without corroborating evidence? Here, I focus on one such exception, in which citizen complaints about the smell of a small shanty
The 2015 Paris Agreement specified that the goal of international climate policy is to strengthen the global response to climate change by restricting the average global warming this century to “well below” 2°C above pre-industrial levels and to pursue efforts to limit it to 1.5°C. In this context, “Negative Emissions Technologies” (NETs)—technologies that remove additional greenhouse gases (GHGs)
Built on up-to-date field material, this edited volume suggests an anthropological approach to the palimpsest-like milieus of Wrocław, Lviv, Chernivtsi, and Chişinău. In these East-Central European borderline cities, the legacies of Nazism, Marxism-Leninism, and violent ethno-nationalism have been revisited in recent decades in search of profound moral reckoning and in response to the challenges p
This article reconstructs the controversies following the release of the figures from Nigeria's 1963 population census. As the basis for the allocation of seats in the federal parliament and for the distribution of resources, the census is a valuable entry point into postcolonial Nigeria's political culture. After presenting an overview of how the Africanist literature has conceptualized the polit
The current national Arctic strategies of Sweden, Norway, and Finland consider tourism as a key industry and point out its significance for sustainable development in the region. Concurrently, China’s Arctic Policy talks about China being the source of tourists to the Arctic. Additionally, the tourism industry’s own strategies recognise that the Asian market shows strong growth in the number of tr
Icy pebbles may play an important role in planet foation close to the water ice line of protoplanetary discs. There, dust coagulation is more efficient and recondensation of vapour on pebbles may enhance their growth outside the ice line. Previous theoretical studies showed that disruption of icy pebbles due to sublimation increases the growth rate of pebbles inside and outside the ice line, by fr
We report angle-resolved measurements on photoelectrons emitted upon near-threshold two-photon double ionization (TPDI) of Kr irradiated by free-electron laser (FEL) pulses. These photoelectron angular distributions (PADs) are compared with the results of semirelativistic R-matrix calculations. As reported by Augustin et al. [Phys. Rev. A 98, 033408 (2018)10.1103/PhysRevA.98.033408], it is found t
Since the 2008 financial crisis, more and more states have started to “sell” citizenships and residence permits to the global economic elite in return for investments. This trade is mediated by transnational firms in the investment citizenship industry, who help governments design and reform the programmes, and assist the wealthy in applying for them. The objective of this article is to explore th
It remains a conundrum in the evolution of sexual communication how the signals and responses can co-ordinate the changes during speciation. The genus Ostrinia contains several closely related species as well as distinctive strains with pheromone polymorphism and represents an ex-ample of ongoing speciation. Extensive studies in the genus, especially in the species the European corn borer O. nubil
Cystic fibrosis-related diabetes mellitus (CFRD) is the most common non-pulmonary co-morbidity in cystic fibrosis (CF). CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to aberrant luminal fluid secretions in organs such as the lungs and pancreas. How dysfunctional CFTR leads to CFRD is still under debate. Both intrinsic effects of dysfu
The electromagnetic character of the ΔI=1 transitions connecting the 1- to 0-phonon and the 2- to 1-phonon wobbling bands should be dominated by an E2 component, due to the collective motion of the entire nuclear charge. In the present work it is shown, based on combined angular correlation and linear polarization measurements, that the mixing ratios of all analyzed connecting transitions between
We investigate the effects of offshoring on job security using matched employer-employee data from Sweden. Between 1997 and 2011, the share of offshoring firms fell from around 25 to 22% while offshoring per worker within offshoring firms almost doubled. We use this variation to contribute to the literature by examining the effects of the neighboring firms’ offshoring (external offshoring) on job
BackgroundSince the mid 80’ies, the western palliative care philosophy has influenced the development of palliative care in mainland China. However, it has caused several challenges.ObjectiveTo explore the understanding of the ‘good death’ among authorities, professionals, patients, and their relatives in end-of-life care settings in mainland China.DesignScoping review. The PRISMA-ScR checklist wa
