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Innate immunity is essential for the anti-microbial defense, but excessive immune activation may cause severe disease. In this study, immunotherapy was shown to prevent excessive innate immune activation and restore the anti-bacterial defense. E. coli-infected Asc−/− mice develop severe acute cystitis, defined by IL-1 hyper-activation, high bacterial counts, and extensive tissue pathology. Here, t

Scanning coherent X-ray microscopy (ptychography) has gained considerable interest during the last decade since the performance of this indirect imaging technique does not necessarily rely on the quality of the X-ray optics and, in principle, can achieve highest spatial resolution in X-ray imaging. The method can be easily extended to 3D by adding standard tomographic reconstruction schemes. Howev

An outbreak of acidity and sulphate salts was observed on the hull of the 17th-century Swedish warship Vasa, following humidity variations in the Vasa Museum during the rainy summer in 2000. Analyses of total sulphur in oak cores sampled from 16 locations showed, in the outermost 2 cm., mean concentrations betwen 0.2 and 6 mass percent. Synchrotron-based sulphur K-edge X-ray absorption spectroscop

Well-differentiated liposarcoma (WDLS) displays amplification of genes on chromosome 12 (Chr12) in supernumerary ring or giant marker chromosomes. These structures have been suggested to develop through chromothripsis, followed by circularization and breakage-fusion-bridge (BFB) cycles. To test this hypothesis, we compared WDLSs with Chr12 amplification in rod-shaped chromosomes with WDLSs with ri

The beta-galactoside-binding mammalian lectin galectin-1 can bind, via its carbohydrate recognition domain (CRD), to various cell surface glycoproteins and has been implicated in a range of cancers. As a consequence of binding to sugar residues on cell surface receptors, it has been shown to have a pleiotropic effect across many cell types and mechanisms, resulting in immune system modulation and

BackgroundThis study aimed to investigate the exposure to perfluoroalkyl substances (PFAS) and cancer-related toxicity in workers in different Swedish industry sectors with exposures to hexavalent chromium (Cr(VI)).MethodsThe study consisted of 111 exposed workers and 72 controls. The exposed workers were performing manufacture/processing of metal products (n=55), working in steel production (n=31

Bacterial reverse transcriptases (RTs) are a large and diverse enzyme family. AbiA, AbiK and Abi-P2 are abortive infection system (Abi) RTs that mediate defense against bacteriophages. What sets Abi RTs apart from other RT enzymes is their ability to synthesize long DNA products of random sequences in a template- and primer-independent manner. Structures of AbiK and Abi-P2 representatives have rec

An important element of antibody-guided vaccine design is the use of neutralizing or opsonic monoclonal antibodies to define protective epitopes in their native three-dimensional conformation. Here, we demonstrate a multimodal mass spectrometry-based strategy for in-depth characterization of antigen–antibody complexes to enable the identification of protective epitopes using the cytolytic exotoxin

Cardiovascular disease (CVD) remains, despite intense research, the most common cause of death world-wide. The main underlying cause of CVD is atherosclerosis, which is characterised by chronic inflammation. CVD and atherosclerosis have a complex aetiology, which necessitates research into multiple areas in order to gain insight into the pathogenesis and find novel markers that could aid in identi

Purpose: Different imaging tools, including digital breast tomosynthesis (DBT), are frequently used for evaluating tumor response during neoadjuvant chemotherapy (NACT). This study aimed to explore whether using artificial intelligence (AI) for serial DBT acquisitions during NACT for breast cancer can predict pathological complete response (pCR) after completion of NACT. Methods: A total of 149 wo

Rheumatoid arthritis (RA) involves several classes of pathogenic autoantibodies, some of which react with type-II collagen (COL2) in articular cartilage. We previously described a subset of COL2 antibodies targeting the F4 epitope (ERGLKGHRGFT) that could be regulatory. Here, using phage display, we developed recombinant antibodies against this epitope and examined the underlying mechanism of acti

The evolution of reading frame maintenance must have been an early event, and presumably preceded the emergence of the three domains Archaea, Bacteria and Eukarya. Features evolved early in reading frame maintenance may still exist in present-day organisms. We show that one such feature may be the modified nucleoside 1-methylguanosine (m(1)G37), which prevents frameshifting and is present adjacent

Invariant natural killer T 1 (iNKT1) cells are prototypic interferon γ-producing, innate-like T lymphocytes that play crucial roles in protection against pathogen infection and cancer. In the thymus, where these cells develop, iNKT cells contribute to the recruitment of antigen-presenting cells and promote T cell tolerance. Although the transcriptional programs guiding iNKT cell specification are

The impact of the microenvironment on innate lymphoid cell (ILC)-mediated immunity in humans remains largely unknown. Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ ILCs across four human tissues. Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood IL

Our elective courses are specially designed to our students in order to broaden and deepen their artistic skills and critical abilities and provide tools to understand and master the artistic discourse in contemporary art. The elective courses are only available to our program students. Elective courses spring semester 2026Infrastructural Aesthetics?Optional BFA level courseCredits: 3Teacher: Sam

https://www.khm.lu.se/en/education/elective-courses-our-programme-students - 2026-05-31

Kognitionsvetenskap, lärande och undervisning – hur hänger det ihop? Kognitionsvetenskap, lärande och undervisning – hur hänger det ihop? Publicerad den 24 februari 2026 Missa inte seminariet den 4 mars då Carola Wiklund-Hörnqvist, universitetslektor vid Institutionen för psykologi vid Umeå universitet föreläser på temat. Presentationen kommer att behandla relationen mellan kognitionsvetenskap, lä

https://www.uvet.lu.se/article/kognitionsvetenskap-laerande-och-undervisning-hur-haenger-det-ihop - 2026-05-07

Lecture 9 - Goodness-of-fit Table of contents 1 Packages 2 Refit all models 2.1 Calculate the expected probabilities using all the models 3 Confusion matrix 4 ROC-curves 4.1 The null model 4.2 The oslo model: 4.3 Plot ROC-curve 4.4 Find best threshold value 4.5 ROC-curves for all the models 5 Area Under the Curve 5.1 AUC for model oslo 5.2 AUC for all the models 5.3 Compare AUC against model oslo

https://www.maths.lu.se/fileadmin/maths/matematisk_statistik/FMSN30_FMSN40_MASM22/lecture09_ex1_oslo_GOF.html - 2026-05-09

Lediga platser på några av höstens högskolepedagogiska kurser Lediga platser på några av höstens högskolepedagogiska kurser Av Caroline Cabot - Publicerad den 6 september 2023 Det finns fortfarande lediga platser kvar på några av höstens högskolepedagogiska kurser som erbjuds vid Avdelningen för högskolepedagogisk utveckling. Introduktionskursen på svenska,  Lärarrollen i högre utbildning  på camp

https://www.ahu.lu.se/article/lediga-platser-paa-naagra-av-hoestens-hoegskolepedagogiska-kurser/ - 2026-05-15

Konferensbidrag sökes: Lunds universitets högskolepedagogiska utvecklingskonferens 2024 Konferensbidrag sökes: Lunds universitets högskolepedagogiska utvecklingskonferens 2024 Av Caroline Cabot - Publicerad den 5 februari 2024 Årets högskolepedagogiska utvecklingskonferens, LUTL, går av stapeln på Forum Medicum den 14 november och har temat Connecting teachers – Changing LU from within. Idén är at

https://www.ahu.lu.se/article/konferensbidrag-soekes-lunds-universitets-hoegskolepedagogiska-utvecklingskonferens-2024/ - 2026-05-28

https://projekt.ht.lu.se/fileadmin/_migrated/content_uploads/STUF_Slutrapport.pdf - 2026-05-30