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Precision diagnostics : moving towards protein biomarker signatures of clinical utility in cancer

Interest in precision diagnostics has been fuelled by the concept that early detection of cancer would benefit patients; that is, if detected early, more tumours should be resectable and treatment more efficacious. Serum contains massive amounts of potentially diagnostic information, and affinity proteomics has risen as an accurate approach to decipher this, to generate actionable information that

Internal gravity-capillary solitary waves in finite depth

We consider a two-dimensional inviscid irrotational flow in a two layer fluid under the effects of gravity and interfacial tension. The upper fluid is bounded above by a rigid lid, and the lower fluid is bounded below by a rigid bottom. We use a spatial dynamics approach and formulate the steady Euler equations as a Hamiltonian system, where we consider the unbounded horizontal coordinate x as a t

Fearing mRNA : A mixed methods study of vaccine rumours

The first mass-distributed vaccines based on mRNA technology were launched in 2021 to protect against COVID-19, sparking rumours among vaccine critical individuals that these “new” vaccines might be more dangerous to the health than other, “traditional” vaccines. Drawing on rumour theories and social cognitive perspectives, the aim of this chapter is to account for the purpose and the spreading of

Wollstonecraft, Mary

Mary Wollstonecraft (1759–1797) was an English philosopher in the Enlightenment tradition, writer, novelist, and book reviewer. She was an advocate for women’s rights and for equality of wealth and privilege and supported the French Revolution. She made her name in 1790 as the author of A Vindication of the Rights of Men, the first published commentary on Edmund Burke’s critique of the French Revo

A Historical Reconstruction of the Changing Relationship Between Forests and People in Japan : A Case Study of Hirosaki Domain in the Nineteenth Century

This chapter explores the relationship between people and forests during Japan’s Tokuagwa period, focusing on Hirosaki domain in northern Honshu, known for its abundant hiba (thujopsis dolabrata) forests. Timber production thrived in the seventeenth century, but by the eighteenth century, resource depletion prompted forest management policies. The 1783 famine accelerated forest devastation, leadin