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Asporin, a novel member of the leucine-rich repeat family of proteins, was partially purified from human articular cartilage and meniscus. Cloning of human and mouse asporin cDNAs revealed that the protein is closely related to decorin and biglycan. It contains a putative propeptide, 4 amino-terminal cysteines, 10 leucine-rich repeats, and 2 C-terminal cysteines. In contrast to decorin and biglyca

Cystatins are natural inhibitors of papain-like (family C1) and legumain-related (family C13) cysteine peptidases. Cystatin D is a type 2 cystatin, a secreted inhibitor found in human saliva and tear fluid. Compared to its homologues, cystatin D presents an unusual inhibition profile with a preferential inhibition cathepsin S > cathepsin H > cathepsin L, and no inhibition of cathepsin B or pig leg

The impact on human ecology of the ivory trade entailed direct and indirect effects. First, the reduction or extermination of elephant populations had direct effects on the vegetation patterns over large areas. Second, the economic activities connected with hunting, transport, and trading affected regional systems of exchange and thereby, indirectly through the political economy, settlements, patt

To improve the sensitivity of thallium-technetium subtraction scintigraphy for preoperative localization procedure of enlarged parathyroid glands in primary hyperparathyroidism, we administered calcitonin intramuscularly 4 hours before the scintigraphy in 14 consecutive patients. Injection of calcitonin reduced plasma levels of ionized calcium from 1.47 +/- 0.10 mmol/l to 1.41 +/- 0.09 mmol/l (p l

This paper brings forward a service oriented perspective, based on practical experiences from designing information systems (IS) as services. Viewing IS as services are beneficial but still an unexplored approach in organizations. In this paper, we present an analysis of Enterprise Resource Planning (ERPs) systems through the perspective of Service Oriented Architecture (SOA). This paper contribut

Aims and objectives: To explore healthcare professionals' conceptions of caring for sick children in home care services. Background: Families often prefer home care to hospital care, and the number of home care services for children is increasing. Caring for children at home has been recognised as challenging for healthcare professionals in home care services used to providing care predominately f

The number of elderly people is gradually increasing, and with it the number of persons receiving some kind of care in their everyday lives. However, researchers and the mass media recurrently report great difficulties for many caregivers in their work situations. This article considers process-oriented supervision as a pedagogic method for training and support of nurse aids and managers in Swedis

We present an architecture supporting ad-hoc composition of pervasive services, an open-source framework that implements it, and the key design principles behind it. The architecture focuses on direct human interaction, supporting combination of devices and services that are not explicitly designed to work together. The focus is on local networks, but extension is possible to wide area networks, i