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We found that engagement of beta (2) integrins on human neutrophils induced activation of RhoA, as indicated by the increased ratio of GTP:GTP + GDP recovered on RhoA and translocation of RhoA to a membrane fraction. The clustering of beta (2) integrins also induced a time-dependent increase in GDP bound to RhoA, which correlated with beta (2) integrin-induced activation of p190RhoGAP. The activat
En hälsoekonomisk utvärdering av cellprovsscreening för cervixcancer har saknats vad gäller svenska förhållanden. I en modellstudie jämfördes effekter av och kostnader för gynekologisk cellprovskontroll med och utan tillägg av test för humant papillomvirus (HPV). Med cellprovsscreening i åldern 32–60 år vart tredje till vart femte år minskar risken att insjukna i invasiv cervixcancer med 88 procen
A total of 44 clinical isolates and the type strain of the putative pathogen Campylobacter concisus were grouped based on their reactions with plant lectins. The optimized lectin typing system used C. concisus strains proteolytically pretreated and subsequently typed by using a panel of four lectins. The system grouped all 45 strains into 13 lectin reaction patterns, leaving no strain untypeable d
Using data from an ongoing Swedish intervention project, the observed durations of nasopharyngeal carriage of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) (MIC of penicillin G of >= 0.5 mu g/ml) stratified by both pneumococcal serogroup and age of the carrier were compared. The means and 95% confidence intervals (CIs) were estimated by fitting a gamma distribution to the observed dura
Klimatet har varit relativt stabilt under den nuvarande interglaciala epoken (Holocen) som inleddes för ungefär 11 700 år sedan. Genom klimatrekonstruktioner från olika geologiska arkiv såsom iskärnor, sjösediment och torvmossar har det ändå påvisats att snabba förändringar i klimatet har inträffat under denna epok. En sådan tidsperiod inträffade för omkring 2800 år sedan och den är intressant ur Geological archives have shown periods of abrupt climate change in the relatively stable Holocene epoch (last ca. 11 700 years). One of these periods was around 2800 cal BP. Several records, mainly from Europe, reveal a shift towards wetter, cooler and windier conditions. There are, however, indications for a global extent of the climate change. The climate change coincides with a distinct increas
Background: To evaluate the pattern of co-infection of human papillomavirus (HPV) types in both sexes in Sweden. Methods: Cell samples from genital swabs, first-void urine, and genital swabs immersed in first-void urine were collected in the present cross-sectional High Throughput HPV Monitoring study. Overall, 31,717 samples from women and 9,949 from men (mean age 25) were tested for 16 HPV types
In sustainability research and elsewhere the notion of resilience is attracting growing interest and causing heated debate. Those focusing on resilience often emphasize its potential to bridge, integrate, and unify disciplines. This paper attempts to evaluate these claims. Resilience is investigated as it appears in several fields, including materials science, psychology, ecology, and sustainabili
Background: Diagnosis of Mycoplasma pneumoniae (MP) infection is traditionally based on serology, which may require more than two weeks for diagnostic antibodies to develop. PCR-based methods offer earlier diagnosis. During a community outbreak of MP infection, we compared seminested and real-time PCR of oropharyngeal swabs with serology for diagnosis of MP infection at different time points after
Intestinal activities are controlled and co-ordinated by way of neuronal reflexes involving both extrinsic and intramural neurones, the enteric nervous system (ENS). This review focuses on the organisation, development and functional properties of the intestinal innervation and of the neurotransmitters utilised.
The therapeutic effect of monoclonal antibody (H57-597 MoAb) against T-cell receptor (TCR) alpha beta has been investigated on MOG(35-55)-induced experimental autoimmune encephalomyelitis (EAE), as a model system for T-cell-mediated chronic inflammation in the central nervous system (CNS). Short-term administration of the anti-TCR alpha beta immediately after immunization protected the mice from E
The aim of this study was to estimate an influence of alpha-ketoglutarate (AKG) on volumetric bone density and geometrical and mechanical properties of the humerus in farm turkeys. All birds were kept under standard rearing conditions with constant access to water and appropriate feed, supplied in accordance with the stage of production cycle. Bone samples were collected 14 weeks after beginning o
We report the isolation and partial genetic characterization of two equine strains of granulocytic Ehrlichia of the genogroup Ehrlichia phagocytophila. Frozen whole-blood samples from two Swedish horses with laboratory-verified granulocytic ehrlichiosis were inoculated into HL-60 cell cultures. Granulocytic Ehrlichia was isolated and propagated from both horses. DNA extracts from the respective st
Synthesis of the antimicrobial protein neutrophil gelatinase-associated lipocalin (NGAL) increases dramatically in bronchial epithelial cells and alveolear type II pneumocytes during lung inflammation. IL-1beta induces a >10-fold up-regulation of NGAL expression in the type II pneumocyte-derived cell line A549 cells, whereas TNF-alpha, IL-6, and LPS had no effect. Similar IL-1beta selectivity was
