Filetype
In the wake of the Second World War, Germany saw an intensive debate about the idea of the university and its future role in society. All were agreed that the country’s universities had to be revitalized after the ravages of Nazism, but the question was what weight should be given to the classical German heritage, and the Humboldtian tradition in particular. The mandarins, the older humanist schol
Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype of ALL, B-cell precursor ALL (BCP-ALL), we conducted a meta-analysis of two GWASs with imputation using 1000 Genomes and UK10K Project data as reference (totaling 1658 cases an
The contribution of host genetic and nongenetic factors to immunological differences in humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral-induced immune transcriptional profiles in an age- and sex-balanced cohort of 1,000 healthy individuals and searched for the determinants of immune response variation. We found that age and sex affected the transcriptional respo
We examined tau haplotype frequencies in two different ethnical groups from the Basque Country (BC): Roma people and residents of European ancestry (general population). In addition, we analyzed the spatial distribution of tau haplotypes in Eurasian populations to explore the genetic affinities of the Romani groups living in Europe in a broader scope. The 17q21.31 genomic region was characterized
On the 24th of January in 2004 a portrait of Reem Raiyshi and her son was published in the Swedish newspaper Aftonbladet. In a short notice the reader was informed that on the 14th of January Reem Raiyshi had killed herself in a terrorist attack at a border crossing between Israel and Gaza. The picture, a still frame from a video, was bought by Aftonbladet from AFP, but has also circulated on the
In recent times, pragmatics has made more and more room for the theory of discourse. The switch in emphasis was triggered, amid other phenomena and theories, by the flourishing pf the communication theory, with its tenet that the process of communication is quite unstable and unpredictable. It is not only the context the one which distorts the transmission of messages, but also the mood of those i
To improve the sensitivity of thallium-technetium subtraction scintigraphy for preoperative localization procedure of enlarged parathyroid glands in primary hyperparathyroidism, we administered calcitonin intramuscularly 4 hours before the scintigraphy in 14 consecutive patients. Injection of calcitonin reduced plasma levels of ionized calcium from 1.47 +/- 0.10 mmol/l to 1.41 +/- 0.09 mmol/l (p l
Erythropoietin (Epo) has been used in the treatment of anemia resulting from numerous etiologies, including renal disease and cancer. However, its effects are controversial and the expression pattern of the Epo receptor (Epo-R) is debated. Using in vivo lineage tracing, we document that within the hematopoietic and mesenchymal lineage, expression of Epo-R is essentially restricted to erythroid lin
In this paper, we analyze the potentials of a four-phase 14-GHz CMOS voltage-controlled oscillator, tailored to a sub-harmonic receiver, for signal processing at Ka-band. When mild phase accuracies between in-phase and quadrature down-converted signals are required, the four-phase oscillator displays roughly the same phase noise figure-of-merit as quadrature oscillator counterparts. However, the o
Introduction Bladder exstrophy is a rare congenital malformation of the bladder and is believed to be a complex disorder with genetic and environmental background. We describe a young adult female with an isolated bladder exstrophy and with an X chromosome aberration. Patients and Methods Karyotyping identified an X chromosome rearrangement that was further characterized with array comparative gen
