Search results

Closed-loop controlled drug dosing has the potential of revolutionizing clinical anesthesia. However, interpatient variability in drug sensitivity poses a central challenge to the synthesis of safe controllers. Identifying a full individual pharmacokinetic–pharmacodynamic (PKPD) model for this synthesis is clinically infeasible due to limited excitation of PKPD dynamics and presence of unmodeled d

The EU’s provisions on cooperation in criminal matters have long allowed for greater flexibility than in other (less sensitive) policy areas. Despite their formal integration into the realm of supranational law under the Lisbon Treaty, they remain subject to some intergovernmental features which are being preserved from the previous pillar structure pre-Lisbon. In particular, this includes opt-out

In the wake of the arrival of cloud computing, future applications are poised to become more resilient and adaptive by embracing elasticity in an osmotic manner. Although cloud computing is a strong attractor for application developers, thereare still unconquered performance frontiers. Latency-sensitive and missioncritical applications make up a significant portion of all software systems, and the

A combination of hydrogen/deuterium (H/D) exchange and limited proteolysis experiments coupled to mass spectrometry analysis was used to depict the conformation in solution of HAMLET, the folding variant of human alpha-lactalbumin, complexed to oleic acid, that induces apoptosis in tumor and immature cells. Although near- and far-UV CD and fluorescence spectroscopy were not able to discriminate be

Results from studies using mice deficient in specific complement factors and clinical data on patients with an inherited deficiency of the classical complement pathway component C2 suggest that the classical pathway is vital for immunity to Streptococcus pneumoniae. However, the consequences of defects in classical pathway activity for opsonization with C3b and the phagocytosis of different S. pne

Most question answering systems feature a step to predict an expected answer type given a question. Li and Roth \cite{li2002learning} proposed an oft-cited taxonomy to the categorize the answer types as well as an annotated data set. While offering a framework compatible with supervised learning, this method builds on a fixed and rigid model that has to be updated when the question-answering domai

Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D

Due to the significant increase in pediatric trunk computed tomography (CT) examinations, there is a need for a reliable approach of conducting effectivedose estimate for such procedures. The current study is based on two dosimetric anthropomorphic phantoms representing a 1-year and a 5-year old child. Effectiveand equivalent tissue doses from CT examinations of the trunk were determined by thermo

Optically stimulated luminescence (OSL) from ordinary household salt has proven high potential for very low dose retrospective dosimetry. In the present paper other common place materials are considered and their dosimetric OSL-properties compared with household salt. The potential for assessment of the effective dose to an individual carrying such materials is investigated.

Establishing diagnostic reference levels (DRLs) in a big country is complicated due to differences in radiological practice between different regions. In 2009-2014, a dose survey was performed in six Russian regions. Based on the results of the survey, preliminary DRLs for conventional X-ray examinations were established on a national level. Additionally, the local authorities were granted the pos

In this paper, the vascular sounds of the arteriovenous fistula at the anastomosis and five centimeters downstream the anastomosis were analyzed. The analysis of the sounds was based on features extracted from the power spectral density (PSD) and wavelet decomposition. The database consists of 15 recordings at the anastomosis and 15 reference recordings obtained from 15 patients. The results showe

Objective. Most methods for measurements of the regional cerebral blood flow are unable to provide absolute blood flow values. Until now interest has been focused on measurement of the gray matter blood flow, while the white matter blood flow has been rather neglected. The aim of the present project was to develop and evaluate an improved method for reliable tomographic measurements of absolute wh

This paper presents a case study evaluating a retrospective analysis method, aimed at improving the release planning activity in project management. The method is based on a re-evaluation of candidate requirements for prior releases in order to uncover release planning decisions that would have been made differently today. The method aims at using the lessons learned during the analysis to find im

Popular Abstract in Swedish Urinvägsinfektioner är en av våra vanligaste infektionssjukdommar. De orsakas främst av den Gramnegativa bakterien Escherishia coli. Normalt hålls urinvägarna sterila av ett effektivt försvar med utsöndring av antimikrobiella faktorer i urinen, men även urinflödet i sig är en viktig faktor i försvaret mot infektioner. Vissa bakterier klarar dock att etablera sig trots dIn this thesis we have used P fimbriated E. coli as a model to investigate the mechanisms of bacterial recognition and cell activation by the urinary tract (UT) epithelium. We show that Toll like receptor 4 (TLR4) is crucial for the recognition and host response to P fimbriated E. coli. This response was independent of LPS and did not require CD14. TLR4 was abundant on epithelial cells throughout

Popular Abstract in Swedish Under 1900-talet har jordbruket förändrats drastiskt. Från ett småskaliga lantbruk där åkrar, ängar och betesmarker avlöste varandra, och varje gård var beroende av att både odla mat och hålla djuren med foder, till ett allt mer specialiserat jordbruk där både de enskilda gårdarna och hela regioner specialiserat sig mot antingen spannmålsproduktion eller djurhållning. OAs a consequence of agricultural intensification, large areas of non-crop habitat have been lost and farmland biodiversity has declined. Previous studies have shown that the extent of non-crop habitat influences farmland biodiversity, but the relative importance of different habitat types is less well known and the contribution of small incidental habitats to landscape-scale species richness is no

In industries like high-tech and automotive, increasingly more of the product value delivered to the customer is based on a combination of hardware (HW) and software (SW), where SW handles much of the differentiation of capacity and features. The “logistics process” of SW, especially when it merges with HW along the process, has so far been little studied but a problem noticed is the difficulties

Competing Institutional Logics in Diaconal Work “Institutional logics” is a concept within the context of institutional theory. Institutions can be defined as patterns of activity rooted in material practices and symbolic systems. These institutional orders are all shaped by the history and each of them has a central logic that guides its organizing principles. The institutional logic provides