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The lack of standardization in patient-reported outcome measures (PROMs) has made measurement and comparison of quality of life (QoL) outcomes in research focused on obesity treatment challenging. This study reports on the results of the second and third global multidisciplinary Standardizing Quality of life measures in Obesity Treatment (S.Q.O.T.) consensus meetings, where a core set of PROMs to

In this work, we use a time-warping-based morphology variation index, dwPCATpe, computed between the peak and the end of the T-wave, and assess its association with the occurrence of ventricular fibrillation (VF) episodes (VF group) in ECG recordings from 20 pigs undergoing a 40-minute coronary occlusion. The dwPCATpe series was obtained by quantifying the morphological differences between the fin

Anemia is a common problem when patients present with cancer, and it can worsen during treatment. Anemia can directly impact the cognitive and physical quality of life and may impair fitness for oncological therapy. The most common cause of anemia is iron deficiency. Newer intravenous (IV) iron formulations offer a safe and rapidly effective treatment option. We performed a systematic mapping revi

This thesis introduces the field of biomedical or diffuse optics and covers basic principles of light propagation in highly scattering media. Physics is well supported by mathematical derivations and equations, which is essential for the development of analytical models. These models are applied to three main fields.First, in photodynamic therapy (PDT) — a promising approach, based on a dynamic in

A synchrotron-based experiment was carried out to demonstrate the potential of x-ray photon correlation spectroscopy (XPCS) to characterize collective dynamics driven by superparamagnetic iron oxide nanoparticles (SPIONs) during magnetomotive ultrasound (MMUS) imaging. MMUS is a developing diagnostic imaging technique that has the potential to enable more precise cancer staging than other clinical

Background: The prevalence of contact allergy in individuals with diabetes and diabetes medical device (MD) users is unknown. Objectives: This study (Part 1 and 2) aims at describing contact allergy prevalences in diabetes MD users. Methods: Adults with type 1 diabetes from two endocrinology departments were patch tested with the Swedish baseline series (SBS) and a MD series. Contact allergies to

Despite their geological significance, the thermochemical processes leading to the formation of early carbonate cements remain elusive. To bridge this knowledge gap, we carried out here laboratory-simulated diagenesis on aragonite ooids. They were placed in autoclaves, filled with distilled water, and subjected to varying temperatures and durations. Our results focus on the transformation from ara

Extreme heat is a growing public health threat in tropical Africa, especially in Ghana where outdoor maximum daily temperatures (Tx) regularly exceed 35 °C. Vulnerability to heat is socially and economically differentiated, with pregnant women, young children, elderly people, and people with chronic health conditions most at risk. High proportions of these groups are found in hospitals, yet little

Heterochromatin is characterized by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However, studying the functional consequences of heterochromatin loss in human cells has been challenging. Here, we used CRISPRi-mediated silencing of the histone methyltransferase SETDB1 to remove H3K9me3 heterochromatin in human neural progenitor cells. Despite

Solution combustion synthesis (SCS) is a rapid and scalable synthetic pathway for producing metallic and oxide nanoparticles and thin films, resulting from the exothermic combustion between a metal cation, chelating organic fuel, and an oxidant. However, understanding the divergence in SCS between thin-film and unconfined bulk combustion, as well as in situ experiments probing the reaction progres

Background: Quantitative SPECT in radionuclide-therapy is limited by partial-volume effects (PVEs). The implementation of regional voxels (r.v.), estimating mean activity concentrations in regions directly from projections, offers a promising alternative for the geometry-specification to reduce PVEs. Purpose: This study aims to demonstrate that activity-concentration estimation with r.v. is superi

BACKGROUND: Several studies have examined the effect of community interventions on youth alcohol consumption, and the results have often been mixed. The aim of this study is to evaluate the effectiveness of a community intervention known as the Öckerö Method on adolescent alcohol consumption and perceived parental attitudes towards adolescent drinking. METHOD: The study is based on a quasi-experim

Background: Deep learning (DL)-based organ segmentation is increasingly used in radiotherapy. While methods exist to generate voxel-wise uncertainty maps from DL-based auto-segmentation models, these maps are rarely presented to clinicians. Purpose: This study aimed to evaluate the impact of DL-generated uncertainty maps on experienced radiation oncologists during the manual correction of DL-based

Loss and damage in fisheries is acknowledged in climate change policy and science but is both undefined and contested, and there is a lack of empirical exploration of the topic. This paper presents the first in-depth, empirical analysis of how fishers’ situated knowledge of socio-ecological changes can inform our understanding of loss and damage in fisheries. The paper conducts a case study from M

Cardiovascular disease (CVD) is the leading cause of death in Europe, with myocardial infarction (MI) being one of its most severe manifestations. While many risk factors for CVD are well known, occupational exposures remain relatively understudied—especially in analyses that adjust for co-occurring workplace exposures. This study aimed to examine the association between occupational exposure to c

Introduction: Prenatal exposure to inflammatory states has been suggested to influence offspring neurodevelopment. The aim was to investigate if offspring exposure to maternal Inflammatory bowel disorder (IBD), or specifically the IBD disorder Crohn's disease, during gestation is associated with neurodevelopmental or psychiatric disorders in childhood. Material and Methods: We conducted a populati