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Resistance to activated protein C (APC) is a major cause of familial thrombophilia, and can be corrected by an anticoagulant activity expressed by purified factor V. We investigated linkage between APC resistance and the factor V gene in a large kindred with familial thrombophilia. Restriction fragment length polymorphisms in exon 13 of the factor V gene were informative in 14 family members. The

PURPOSE: Leukemic stem cells (LSCs) may harbor important resistance to tyrosine kinase inhibitors in chronic myeloid leukemia (CML). We identified Philadelphia chromosome (Ph) positive CD34+CD38- bone marrow cells (here denoted LSCs) and addressed their response-predictive value in CML patients (n=48) subjected to nilotinib in the ENEST1st trial (NCT01061177).EXPERIMENTAL DESIGN: Two flow cytometr

Aim: The aim of this study was to explore and understand the complexity of ageing in relation to factors of importance for extending working life. Method: Discourse analysis of documents was used in an integrative review including 128 articles. Result: Four different conceptualisation of ageing are shown to affect older workers’ ability to extend their working life: (a) biological ageing people’s

Increased intraocular pressure (IOP) is a major risk factor for glaucoma, and its contribution to neuronal damage appears multi-factorial. An open issue is whether pressure effects on blood vessels contribute to neuronal damage. In particular, little is known about pressure effects on capillaries, which are the site of most metabolic exchange in the retina, but cannot be easily visualized in vivo.

This chapter highlights how implementing circular economy principles can help companies working with sustainability to move from a reductionist and waste management approach to marketing competitive circular value propositions that intentionally design out waste (e.g. emissions and pollution) by rethinking, reinventing and redesigning the value chain. Schijvens, a Dutch family-owned corporate fash

This chapter gives an account of Pufendorf’s discussion and use of the law of nations. It first outlines his distinctive contribution to contemporary discussions of the topic, namely his rejection rejection, against Grotius, of a specific “positive” law of nations distinct from the law of nature. Secondly it explains how this position relied on Pufendorf’s voluntarist conception of law as the comm

A search for high-mass charged and neutral bosons decaying to Wγ and Zγ final states is presented in this paper. The analysis uses a data sample of s = 13 TeV proton-proton collisions with an integrated luminosity of 139 fb −1 collected by the ATLAS detector during LHC Run 2 operation. The sensitivity of the search is determined using models of the production and decay of spin-1 charged bosons and

The development of quantum simulators, artificial platforms where the predictions of many-body theories of correlated quantum materials can be tested in a controllable and tunable way, is one of the main challenges of condensed matter physics. Here we introduce artificial lattices made of lead halide perovskite nanocubes as a new platform to simulate and investigate the physics of correlated quant