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The precisionFDA Truth Challenge V2 aimed to assess the state of the art of variant calling in challenging genomic regions. Starting with FASTQs, 20 challenge participants applied their variant-calling pipelines and submitted 64 variant call sets for one or more sequencing technologies (Illumina, PacBio HiFi, and Oxford Nanopore Technologies). Submissions were evaluated following best practices fo
Popular Abstract in Swedish Bakgrund I Sverige erbjuds samtliga gravida kvinnor ett rutinultraljud vid 18-20 graviditetsveckor. Syftet med undersökningen är att fastställa antalet foster, uppskatta graviditetslängd samt granska fosteranatomin för att upptäcka eventuella missbildningar. En del missbildningar kan man se med ultraljud, men långtifrån alla. Att redan under graviditeten känna till om The aim was to evaluate first trimester nuchal translucency (NT) measurement for detection and risk assessment of fetal malformations and fetal loss. 39 572 pregnant women were randomised to either a routine ultrasound scan at 12-14 weeks including NT measurement or to a routine scan at 18-20 weeks. Prenatal diagnosis of major congenital heart malformations was compared between the two groups. In
Vertebrates capable of powered flight rely on wings, muscles that drive their flapping and sensory inputs to the brain allowing for control of the motor output. In birds, the wings are formed of arrangements of adjacent flight feathers (remiges), whereas the wings of bats consist of double-layered skin membrane stretched out between the forelimb skeleton, body and legs. Bird feathers become worn f
The main aim of this thesis is to analyze the process of institutionalization and neo-/interdisciplinarization in Women’s/Gender/Feminist Studies (WGFS) in Sweden, and the construction of feminist knowledge within this process. Furthermore, the thesis aims to contribute to the feminist debates on academic feminism as a transformative project. Three questions have guided the research process: 1) Ho
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A lot of attention has been focused on the policy stream of the multiple streams framework (MSF). John Kingdon used the role of the policy entrepreneur to theorize what was going on when problems become political issues. In order to fully grasp this process we need to further theorize also the problem stream. What is going on in the problem stream is defining the conditions for coupling done by po
The infrastructure for 3G has been under development in Sweden since late 2000. Following from the so called beauty contest four operators within three years were to build competing systems to cover 99,98 percent of the population by the end of 2003, giving the administrative system an extreme challenge. Issues widely debated has been the alleged hazardousness of the electromagnetic radiation from
The paper investigates the development of energy efficient windows in the past 30 years. The focus is on the development and interlinkages among technology, actors´ interaction and market diffusion in a broader policy context. The paper shows that in singular development cycles, different factors and the interfaces among these factors influenced the improvement and penetration of energy efficient
The aim of this chapter is twofold. First, it deliberates the insufficiency of the ethnically loaded hyphenated identity of ‘Euro-Turks’ in defining the diverse diasporic community of Turkey’s citizens and/or their descendants in Europe. Second, it lays out the advantages and disadvantages of using the Türkiyeli concept as an alternative to the hyphenated identity Euro-Turks, which allows peoples
We use a unique source from the Swedish royal demesnes to examine the work and relative wages of women in sixteenth-century Sweden, an economic laggard in the early modern period. The source pertains to workers hired on yearly contracts, a type more representative of historical labour markets than day labour on large construction sites, and this allows us to observe directly the food consumed by w
Substantial variability exists in what pathologists consider as pT4a in colorectal cancer when tumor cells are within 1 mm of the free peritoneal surface. This study aimed to determine if the measured sub-millimeter distance between tumor cells and the free peritoneal surface would offer an objective means of stratifying patients according to the risk of developing peritoneal metastases. Histologi
Through interviews, many documents and secondary data, this dissertation investigates how fifty-four women activists participated in the public sphere in Egypt from the outbreak of the 2011 uprising to the re-emergence of the authoritarian regime in 2014. The women activists studied in the dissertation took part in various counter-publics of social movements, opposition political parties, and civi
Samverkan har sedan lång tid tillbaka varit viktigt inom både regionala ochkommunala verksamheter och det finns mycket som talar för attsamverkansbehoven kommer att öka än mer. Inom hälso- och sjukvården finns en kontinuerlig utveckling mot ny och mera specialiserad kunskap som även fårorganisatoriska konsekvenser. Teamarbete i vården har blivit allt viktigare, liksom nivåstrukturering och koncentCooperation has long been important within both regional andmunicipal activities and there is much to suggest thatcollaboration needs will increase even more. Within health care there is onecontinuous development towards new and more specialized knowledge that also gains organizational consequences. Teamwork in healthcare has become increasingly important, as well level structuring and concentrati
AimEndometriosis is one of the most common gynecologic diseases in women of reproductive age. The pathophysiology of endometriosis is still not fully understood. Phoenixin (PNX-14) is a newly discovered neuropeptide that regulates the hypothalamo–pituitary–gonadal (HPG) axis and reproductive functions. Recently, we reported that PNX-14, its precursor protein and receptor were expressed in human en
Shopping centres are products and indicators of consumerism. In the case of Israel/Palestine, where shopping malls have spread since the mid-1980s, they have acquired political meanings beyond the widespread conception of consumer-choice-as-freedom, as they also claim to advance coexistence in a context marked by ethnic segregation. We perceive shopping centres as ‘non-places’, following the work
Individual patient data were available for all four of the randomized trials that began before 1995, and that compared adjuvant radiotherapy vs no radiotherapy following breast-conserving surgery for ductal carcinoma in situ (DCIS). A total of 3729 women were eligible for analysis. Radiotherapy reduced the absolute 10-year risk of any ipsilateral breast event (ie, either recurrent DCIS or invasive
Fiberbanks have recently received attention as potential greenhouse gas (GHG) sources in Sweden. Fiberbanks are anthropogenically caused fibre-rich sediments in aquatic environments formed by unregulated discharge of fibrous wastewater from historical pulp and paper industries. A majority of fiberbanks show signs of gas ebullition, mainly consisting of methane and carbon dioxide, resulting from an
