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The notion of the phoneme counts as a break-through of modern theoretical linguistics in the early twentieth century. It paved the way for descriptions of distinctive features at different levels in linguistics. Although it has since then had a turbulent existence across altering theoretical positions, it remains a powerful concept of a fundamental unit in spoken language. At the same time, its co
The aim of this chapter is to contribute to the debate by arguing for an approach to validity in which (1) the domain of discovery and the domain of justification are brought together and are seen as being intertwined in a transactional sense, (2) the justification process is seen to be endowed with an experimential and a contextual dimension, and (3) a pro¬ces¬sual, historical pespective is thus
We consider whether stellar collisions can explain the observed depletion of red giants in the Galactic center. We model the stellar population with two different IMFs: 1) the Miller-Scalo and 2) a much flatter IMF. In the former case, low-mass main-sequence stars dominate the population, and collisions are unable to remove red giants out to 0.4 pc although brighter red giants much closer in may b
Do the CNS monoaminergic (MA) systems regulate thyroid hormone metabolism in humans? In 23 unmedicated, male, violent offenders without signs of thyroid disease, we found positive correlations between the catecholaminergic CSF metabolites HVA and MHPG and the peripheral T3/T4 ratio (rho=0.55, p=0.010 and 0.51, p=0.018), indicating that increased activity in the brain MA systems, especially the dop
The interpretation of ecological data has been greatly improved by bridging the gap between ecological and statistical models. The major challenge is to separate competing hypotheses concerning demography, or other ecological relationships, and environmental variability (noise). In this paper we demonstrate that this may be an arduous, if not impossible, task. It is the lack of adequate ecological
Patients with hemophilia have an impaired thrombin Generation and therefore form loose fibrin hemostatic plugs that are easily dissolved by fibrinolysis. This prevents maintained hemostasis in these patients, resulting in a severe bleeding disorder. Recombinant (F)VIIa has been shown to enhance thrombin generation on already thrombin-activated platelets in the absence of FVIII and FIX. An efficacy
Objectves To obtain information on the mechanisms of female rat micturition using a model in which pressure was measured in the bladder and distal part of the urethra corresponding to the location of the rhabdosphincter, providing information on the role of the sphincter in opening and closing the urethral lumen. Materials and Methods A micturition reflex was induced in adult anaesthetized (chlora
Previous studies have suggested that the Trp460 allele of the Gly460Trp polymorphism in the alpha-adducin gene is associated with salt sensitivity and primary hypertension. The present study was undertaken to evaluate if the Trp460 allele of this polymorphism is associated with primary hypertension in Scandinavians. To address this issue, 294 patients with primary hypertension and 265 normotensive
Glycosphingolipids and sphingomyelin (SM) are important components of the apical brush border and the Golgi and enclocytic vesicles of the gut epithelium. In particular, glucosylceramide is abundant in the microvilli. Synthesis and degradation of mucosal sphingolipids and targeting of sphingolipids to distinct cell compartments during cell differentiation are thus important features of intestinal
This study compared the realism of witnesses’ confidence judgments of their own recall elicited in either the Cognitive Interview (CI) or the Structured Interview (SI). Calibration methodology was used to analyze the realism of the confidence judgments. Participants (N = 56) were interviewed about their observations of a staged crime and returned two weeks later to assess their confidence in the
Objective: To describe the phenotype of the Bardet-Biedl syndrome in patients with mutations in the BBS4 gene. Methods: We examined 3 pairs of siblings with Bardet-Biedl syndrome in whom 3 different mutations in the BBS4 gene were detected, 2 of which were homozygous for the mutation. Results: All patients had an increased body mass index. The obesity varied between families from moderate to sever
The distribution of peptide-containing nerve fibers in the pharyngeal region of rabbits was studied by immunocytochemistry. Neuropeptide Y (NPY)-containing fibers were numerous around blood vessels and moderate in number among bundles of striated muscle fibers. A few NPY-containing fibers were seen around seromucous glands and beneath the epithelium. Nerve fibers containing vasoactive intestinal p
