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The majority of breast cancers express estrogen receptor α (ERα), and most patients with ERα-positive breast cancer benefit from antiestrogen therapy. The ERα-modulator tamoxifen and ERα-downregulator fulvestrant are commonly employed antiestrogens. Antiestrogen resistance remains a clinical challenge, with few effective treatments available for patients with antiestrogen-resistant breast cancer.
South Africa is a complex and dynamic society, with overwhelming and increasing problems with disaster risk in the vulnerable urban communities in and around its rapidly growing metropolitan centres. The purpose of this study is to improve the understanding of the challenges for disaster risk reduction in such communities. It focuses on the case of Imizamo Yethu, in the Western Cape, in order to b
The onset of cellular instability in adiabatic H-2/O-2/N-2 premixed flames anchored to a heat-flux burner is investigated numerically. Both hydrodynamic instability and diffusional-thermal instability are shown to play an important role in the onset of cellular flames. The burner can effectively suppress cellular instability when the flames are close to the burner, otherwise the burner can suppres
Populärvetenskaplig sammanfattning Det finns två huvudsakliga typer av diabetes, typ 1 (T1D) och typ 2 (T2D), samt flertalet mindre vanliga former av diabetes t.ex. MODY. I bukspottkörtelns β-celler produceras insulin, vilket är det mest centrala hormonet i regleringen av blodsockret som verkar genom att öka cellernas upptag av socker från blodet. T2D, tidigare kallad åldersdiabetes, beror till sABSTRACT The prevalence of diabetes keeps increasing around the world, of which type 2 diabetes (T2D) accounts for 90%. Both lifestyle and genetic factors contribute to pathogenesis of the disease. A significant proportion of the basic research on T2D focuses on the genetic components and susceptibility genes especially on the insulin secretion. Herein, we functionally examined 4 T2D candidate ge
The introduction of scientific research evidence through evidence-based practice (EBP) into occupational therapy can potentially be used to reform and transform the profession, both as a limiting and defining process as well as a broadening and developing process. Two different approaches to the topic of EBP were found in this review. They are comprised of a position favoring a traditional evidenc
Denna uppsats behandlar frågor om allemansrätt och hur den förhåller sig till olika typer av områdesskydd i 7 kap. Miljöbalken (MB), främst naturreservat. Skyddsformen naturreservat utgör del i en bas av de skyddsinstrument som finns för att skydda värdefulla naturområden. Lagstiftaren framhåller det som viktigt att värna om allemansrätten och att inte begränsa den i onödan i skyddade naturområThis thesis treats questions about common right of access to private land and its relation to different types of protected areas in Chapter 7 of the Environmental Code, considering mainly nature reserve. Nature reserve as a form of protection is part of the elementary forms of protecting valuable nature areas. According to the legislator it is important to uphold the common right of access to pr
Syftet med studien var att undersöka upplevelsen hos föräldrar till tonåringar relaterat till deras deltagande i COPE-föräldrautbildning för att få en förståelse för föräldraskapet och dess svårigheter. Vidare, utforskade studien motiven till att söka föräldrautbildning och även den inverkan som föräldrautbildningen hade på föräldrarna. För att uppnå resultaten genomfördes åtta stycken halvstruktuThe aim of the research is to account for the experiences of the parents of teenagers related to their participation in COPE-parenting program in order to gain the understanding for parenting and its difficulties. Moreover the study investigates the motives for applying for parenting program and also the impact that the participation in the parenting program had on the parents. In order to attain
Understanding how time-reversal symmetry (TRS) breaks in quantum materials is key to uncovering new states of matter and advancing quantum technologies. However, unraveling the interplay between TRS breaking, charge order, and superconductivity in kagome metals continues to be a compelling challenge. Here, we investigate the kagome metal Cs(V1−xNbx)3Sb5 with x = 0.07 using muon spin rotation (μSR)
This paper takes a critical look at current methodologies used by business for assessing impacts on indigenous communities dependent upon natural resources for the maintenance of their traditional way of life. It argues that new human-centered, holistic and bottom-up approaches can contribute to a greater understanding of direct, indirect and cumulative impacts of resource development on indigenou
Phenological observations of terrestrial ecosystems are useful in monitoring the changes in the local climate due to their relatively long time series and high temporal resolution. However performing field based phenological observations can be a labour intensive and time consuming process. Using satellite-based remotely sensed data can make the process much more efficient. Although the satellites
Klimatförändringar har amplifierats sedan den industriella revolutionen och modeller pekar på att förändringen kommer forsätta att öka åtminstone till slutet av detta århundrande. Globala temperaturer och nederbörd förväntas öka avsevärt under detta århundrade. Dessa ökningar förväntas bli särskilt markanta i de arktiska områdena. Torvmyrar belägna på höga latituder vid 0ºC isothermen, såsom StorfThe rate of change of our climate has been amplified since the industrial revolution and is expected to change even further by the end of this century. Global temperature and precipitation are expected to increase considerably over the next century. These increases are expected to be magnified in the Arctic regions. In a high latitude peatland like Storflaket, near Abisko (Northern Sweden), at the
Glucagon, secreted by the pancreatic alpha-cells, stimulates insulin secretion from neighboring beta-cells by cAMP- and protein kinase A (PKA)-dependent mechanisms, but it is not known whether glucagon also modulates its own secretion. We have addressed this issue by combining recordings of membrane capacitance (to monitor exocytosis) in individual alpha-cells with biochemical assays of glucagon s
Background: There are no predictors known that can identify COPD patients who will respond to treatment with ICS. Method: We investigated 30 patients (median age 65 (range 44-83, 12 females) with mild to moderately severe COPD. All patients had post bronchodilator FEV1/forced vital capacity ratio of less than 70% and a reversibility of less than 12% and 200 ml from baseline. We wanted to determine
Background:Past studies have reported a correlation between the presence and severity of periodontitis and serum antibody titers to species-specific antigens of Porphyromonas gingivalis or to cross-reactive antigens, such as lipopolysaccharide (LPS) and heat shock proteins (HSP), shared between P. gingivalis and other bacteria. Our recent study of periodontal treatment outcome in insulin-dependent
The exact diagonalization technique is used to study many-particle properties of interacting electrons with spin, confined in a two-dimensional harmonic potential. The single-particle basis is limited to the lowest Landau level. The results are analysed as a function of the total angular momentum of the system. Only at angular momenta corresponding to the filling factors 1, 1/3, 1/5, etc is the sy
