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Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incompletely understood. We therefore examined genetic associations with HF in a large national biobank, and assessed whether refined phenotypic classification would facilitate genetic discovery. Methods: We defined all-cause HF among 488 010 participants from the UK Biobank and performed a genome-wide a
Objective: To investigate the causal role of cardiometabolic risk factors in osteoarthritis (OA) using associated genetic variants. Methods: We studied 27,691 adults from the Malmö Diet and Cancer Study (MDCS) and replicated novel findings among 376,435 adults from the UK Biobank. Trait-specific polygenic risk scores for low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol
PurposeThe purpose of this paper is to explore if the application of a framework building on organisational learning focusing on organisational processes can increase our understanding of how hybrid organisation develops over time and why they fail to live up to external expectations.Design/methodology/approachThe aim of this study is descriptive and explorative. It is accordingly designed as a qu
Background: The prognosis of Alzheimer’s disease (AD) might be influenced by many sociodemographic and clinical factors. Previous studies have investigated the main effects of critical predictors but few have analyzed potential interactions. We have studied the long-term cognitive outcome, nursing home placement (NHP) and mortality by interactions between factors in cholinesterase inhibitor (ChEI)
Aims: People who have schizophrenia die earlier from somatic diseases than do people in the general population, but information about cardiovascular deaths in people who have schizophrenia is limited. We analysed mortality in all age groups of people with schizophrenia by specific cardiovascular diseases (CVDs), focusing on five CVD diagnoses: coronary heart disease, acute myocardial infarction, c
GRASP (Group and Social Psychology) is an interdisciplinary conference, which aims to provide a community around social psychological issues for researchers, practitioners, and graduate students from the Nordic countries within the fields of psychology, sociology, education, behavioural sciences and social work to share, exchange, learn, and develop preliminary results, new concepts, ideas, princi
Aims/hypothesis: Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. Methods: We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneous autoimmune type 1 diabetes) and diabetes-resistant DRLyp/+ and DR+/+ litterma
Vi har lyckan att leva i en föränderlig värld, och med förändringar följer variation. Den stora variationen i yttre egenskaper hos djur, och i synnerhet deras färger, fascinerar både forskare och lekmän. I den här avhandlingen utforskar jag flera aspekter på varför, och hur, färgvariation evolverar hos en karismatisk insektsgrupp. Dammflicksländor är färgglada, dagaktiva och visuellt drivna organiSexual conflict over mating shapes the interactions between males and females in many animals and is also responsible for dramatic adaptations in both sexes. In some species of pond damselflies (Odonata:Coeangrionidae), sexual conflict maintains discrete female-limited colour morphs over multiple generations and within populations. One of the female morphs is typically male-coloured and considered
BACKGROUND: Patellofemoral arthroplasty (PFA) is one option for the treatment of isolated patellofemoral osteoarthritis, but there are limited data regarding the procedure and results. Because isolated patellofemoral arthritis is relatively uncommon, available case series generally are small, and even within national registries, sample sizes are limited. Combining data from multiple registries may
In the age of museomics, the ability to sequence the genetic material from old museum specimens provides an invaluable and often untapped molecular resource. The application of the latest Next-Generation sequencing (NGS) technologies to such specimens allows us to utilise the diverse biobank that is natural history museums. These approaches provide the opportunity to study both extinct or difficul
AbstractThe primary purpose of understanding disease etiology is to explain how a specific phenotype is determined by genotype. In pursue of this aim, exploring the diversity in DNA sequence variants that affect biomedical traits, especially those related to the onset and progression of genetically determined human disease. The human leukocyte antigens (HLA) are highly polymorphic cell surface pro
Prostatacancer är den vanligaste cancern bland män i Sverige. Varje år insjuknar ca 10 000. Sjukdomen är starkt åldersberoende och är mycket vanlig bland äldre män. Latent cancer (icke kliniskt signifikant) förekommer ofta. Sjukdomen klassificeras som låg, mellan eller högrisk baserat på Gleason summa (tumörens aggressivitet), stadium och PSA. Val av behandling sker utifrån riskgrupp och ålder. Lå
Background: Women who deliver pre-term have been reported to have increased future risks of cardiometabolic disorders. However, their long-term risks of ischemic heart disease (IHD) and whether such risks are due to shared familial factors are unclear. A better understanding of these risks may help improve long-term clinical follow-up and interventions to prevent IHD in women. Objectives: The purp
Trots likadana tekniska förutsättningar visade den aktuella avhandlingen på att energianvändningen varierade stort mellan hushåll – vilket även tidigare forskning pekat på. Det skiljde en faktor två till tre mellan högsta och lägsta energianvändningen för de grupper av likadana hus som studerades. Skillnaden i vattenanvändning var ännu större, nämnare bestämt en faktor sex. De boendes val och vardTo achieve global energy goals, energy use in residential buildings must decrease. The implementation of technical measures is crucial but alone it is not sufficient; residents need to change their behaviour as well. However, households are not a homogeneous group in terms of their energy use and behaviour; rather, the use varies between households and over time. To promote energy savings in build
Background: Regimens based on ibrutinib alone and lenalidomide and rituximab in combination show high activity in patients with relapsed or refractory mantle cell lymphoma. We hypothesised that the combination of all three drugs would improve efficacy compared with previously published data on either regimen alone. Methods: In this multicentre, open-label, single-arm, phase 2 trial, we enrolled pa
Background: Seasonal variation in glucose metabolism might be driven by changes in daylight. Melatonin entrains circadian regulation and is directly associated with daylight. The relationship between melatonin receptor 1B gene variants with glycemic traits and type 2 diabetes is well established. We studied if daylight length was associated with glycemic traits and if it modified the relationship
Background: Ovarian tumours are usually surgically removed because of the presumed risk of complications. Few large prospective studies on long-term follow-up of adnexal masses exist. We aimed to estimate the cumulative incidence of cyst complications and malignancy during the first 2 years of follow-up after adnexal masses have been classified as benign by use of ultrasonography. Methods: In the
Background: The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V), versus two MMR doses (control vaccine) for the prevention of confirmed varicella. Metho
Proficiency in writing is a central graduate attribute of higher education. In practice, this means that students are expected to acquire both generic and discipline-specific writing skills that will be beneficial for their professional lives. Although the learning outcomes for many courses include the ability to express oneself in writing, a predominant function of writing is that of mere testing
