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This explorative study aimed to apply, develop, and evaluate assessment methods at various levels in cell replacement therapy for Parkinson’s disease (PD). Observed motor effects in five grafted patients support that timed motor tasks and clinical ratings of parkinsonism are able to monitor motor function, but their psychometric properties need further attention. Using positron emission tomograp

This thesis discusses aspects of feeding habits of moose (Alces alces) and their impact on forest development. The development of forage that is available to moose was studied by sampling the amount of edible biomass on pine and birch trees. A strong relationship was found between foliage (and twig) biomass and tree diameter, which corroborates the hypothesis that sapwood area limits the amount of

Complex I or NADH:quinone oxidoreductase is the largest enzyme complex, but the least understood energy coupling site in the respiratory chain of mitochondria and bacteria. No high-resolution structural information exists for this enzyme and the molecular mechanism that couples electron transfer and proton pumping is not understood. In mammals, about 50% of the mitochondrial DNA is encoding protei

Several analyses using time-resolved optical spectrocopy of pulsating white dwarfs are presented. The data have been put to a number of uses. First, line-of-sight velocities associated with the pulsations have been measured in three hydrogen-atmosphere white dwarfs (DAVs), bringing the total number of such measurements up to five. They have also been measured for the first time in a pulsating heli

The overall aim of this thesis was to investigate quality of life and the meaning of living with peripheral arterial disease (PAD) before and after revascularization in a long-term and methodological perspective. The sample in the first study consisted of 142 patients with PAD who were planned for a revascularization. Quality of life (QoL) assessment with the Nottingham Health Profile (NHP) was ma

Objective: To explore the long-term course and to study factors of potential relevance for the treatment and rehabilitation process of patients with schizophrenia and schizophrenia-like disorders. Specific issues concerned cognitive reduction, tardive dyskinesia (TD), prolactin-induced side effects, remission and lack of insight. Method: A naturalistic multicenter study of 225 patients, diagnosed

The thesis consists of three different purposes. Purpose number one entails describing and analysing the legal opportunities for, and the demands on, the work of the actors in question with regard to children as victims of crime. This purpose intends to illustrate the legal regulation, which in different ways, and to different degrees, controls the work of the actors. Whereas the legislation provi

Use of beta-blockers and inhibitors of the renin angiotensin system (RAS) is established practice in the treatment of chronic heart failure (CHF). Clinical studies also suggest beneficial long-term effects of nitrates in CHF. In the Veterans Administration Heart Failure Trial (V-HeFT) I, the combined use of a nitrate and hydralazine reduced the mortality rate. However, it is not possible to determ

This thesis puts a focus on school leadership and school development. The local authorities took over responsibility for public education in 1991. At the same time, steerage by rules was abandoned in favour of steerage by goal-setting and result evaluation. The principal is an important link in this chain of steerage. The question posed by the thesis concerns whether there are common norms for th

The aims were to follow stroke patients over time with respect to general pain, shoulder pain, weight loss, and health related quality of life (HRQOL), the latter also in stroke survivors' informal caregivers. Methods During a 1 year period, 416 first-ever stroke patients were included in the population based Lund Stroke Register; 327 survivors were followed up after four months and 305 one year

The purpose of this study was to (I) assess the association between body mass index (BMI) and total hip replacement (THR) and total knee replacement (TKR) due to osteoarthritis (OA), (II) assess the association between the mechanical load of work and THR and TKR due to OA, (III) evaluate the natural history of radiographic hip OA with regards to THR and hip fracture, (IV) to determine the prevalen

The aim of thesis was to investigate the nurse-patient encounter in dementia care (n=9 patients), functional and cognitive ability, behaviours and mood of the patients as well as the reliability of the instruments used (n=75 nursing home patients). A further aim was to investigate the effects on the aspects mentioned above of a one-year controlled intervention (individually planned care and clinic

The aim of this thesis was to investigate nurses’ lived experience of daily nursing care and the impact and lived experiences of one years intervention with systematic clinical group supervision and supervised individually planned nur-sing care. This was carried out at an experimental ward (EW) (n=19) housing patients with dementia in comparison with a similar control ward (CW) (n=20) using a quas

Better understanding of suicidality may improve treatment and care of suicide attempters. This thesis aims at understanding suicidality by investigating suicide risk, sex differences and views of suicide attempters. Suicide risk factors (prospectively determined) differed between the sexes: Older age and high suicidal intent were female risk factors, whereas previous attempts and using a violent

a1-microglobulin is a small glycoprotein present in plasma and in tissues surrounding the gastrointestinal and respiratory tracts. a1-microglobulin is a member of the lipocalin protein family and exhibits several of the typical traits of a lipocalin; it binds an unknown ligand which causes the brown color of the protein, it forms complexes with various different proteins and there have been indica

The Struggle for High and Low Culture. Studies in the Late Twentieth Century Novel’s Relationship to Mass Culture and Modernity. It is a widespread opinion that the boundaries between high culture and mass culture have become less defined in our postmodern culture. How is the aesthetic exchange to be interpreted between cultural spheres – high and low respectively – long considered incompatible?

The overall aim of the thesis was to investigate the effects of psychodynamically oriented psychotherapy and gain an increased understanding of the curative factors in psychotherapy by thorough examination of the therapeutic alliance and of client change. The core of the thesis is a naturalistic study of 22 short-term dynamic psychotherapies and a follow-up 6-12 months later. Individual outcome me

Hereditary retinal degenerations are the most frequent reason for severe visual handicap among young people in Scandinavia today. In the six papers included in this thesis the phenotypic expressions, with emphasis on the electrophysiological findings, of five different juvenile hereditary retinal degenerations are described. The diagnoses have been confirmed by genetic analysis. The retinal disord