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Programmatic vaccination and screening are the reasons for this thesis. The practice of public health incorporating medicine’s cognitive contents along with contributions from other fields of human activities is basically a moral enterprise. It is important that limitations from the whole continuum of these interventions are recognized to retain credibility. The changing demands resulting from the

Spondyloarthritis (SpA) is a group of interrelated inflammatory rheumatic diseases with the sub-diagnoses ankylosing spondylitis (AS), psoriatic arthritis (PsA), arthritis-associated inflammatory bowel disease (Aa-IBD), undifferentiated SpA (USpA), where stiffness and pain are key symptoms. Insidious onset back pain, morning stiffness, waking up at night, and improvement from exercise are common c

Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. Like pancreatic β-cells, which produce insulin, α-cells are electrically excitable and equipped with dif

L-type voltage-gated Ca2+ channels are expressed in the plasma membrane of muscles, neurons and endocrine cells where they serve as conductors of signals regulating cellular responses to changes in environment. Malfunctions of channels, as well as deregulations of their activity underlie numerous disorders and diseases commonly called channelopathies. In β-cells Ca2+ channels are central players f

Tolerance is crucial for maintaining immunological balance and avoid autoimmune diseases like type 1 diabetes and the inflammatory bowel disease, ulcerative colitis (UC). In Study I, we have investigated the regulatory role of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. We used the non-obese diabetic mouse (NOD) which is spon

The reactor containment is one of the most important buildings at a nuclear power plant. In case of an accident the containment wall is the final protection against radioactive leakage to the surrounding environment. A reactor containment contains different types of concrete structures. They can be grouped as external structures constituting a barrier between the inside of the containment and the

Medications are of considerable help if healthcare providers are able to administer them to patients safely and appropriately. The medication use process is complex and a team of professionals – doctors, nurses, and pharmacists – work together with the patient for optimal treatment effect. The process involves many sub-processes and in every step there is a possibility for an error. Cytotoxic drug

Background: Excessive and inappropriate use of antibiotics is considered to be the most important reason for development of bacterial resistance to antibiotics. As antibiotic resistance may spread across borders, high prevalence countries may serve as a source of bacterial resistance for countries with a low prevalence. Therefore, bacterial resistance is an important issue with a potential serious

Background: Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants. Objective: The objective of the study was to identify common genetic variants that are associated with macronutrient intake. Design: We performed 2-stage genome-wide association (GWA) meta-analysis of macronutrient intake in populations o

Bacterial invasion of a damselfly reduces genetic diversity Wolbachia is a common bacterium that lives in the cells of a great diversity of insects. This bacterium is a great manipulator of insect biology. In the blue moon butterfly (Hypolimnas bolina), Wolbachia kills male embryos so there is as little as one male blue moon for a staggering one hundred females. Additionally, in some species of w

Livstids fängelse kunde innan 2006 endast tidsbestämmas genom det s.k. nådeinstitutet. Genom införandet av lag (2006:45) om omvandling av fängelse på livstid utökades möjligheten för livstidsfångar att få sitt straff tidsbestämt. Syftet med införande av lagen var att förbättra förutsebarheten, inte bara för de intagna utan även för de dömdas anhöriga och KRV vid dess arbete med de intagna. I motiBefore 2006, the only way life sentences could be converted was through governmental clemency. The adoption of the 2006 Conversion of Life Imprisonment Act (2006:45) (OmvL), however, increased the possibilities for prisoners serving life in prison to have their sentences commuted to a set number of years. The purpose of the adoption was to improve legal predictability for inmates, their relatives,

E-commerce activities have been growing rapidly throughout the past decade, leading to a growth just as dominant in last mile logistics and urban freight transport as well. Different factors create these deliveries highly inefficient, expensive, and polluting. This led to the generation of major problems that became more dominant in urban areas. Such problems created in cities contributed to highe

Denna uppsats behandlar den förhållandevis oklara skatterättsliga regleringen av näringsverksamheters avdrag för sponsrings- och klimatkompensationsutgifter. Oklarheterna kan antas påverka skattskyldigas incitament för att ge sådana bidrag och därmed motverka uppfyllandet av Sveriges klimatmål. Uppsatsen utreder också hur HFD har gått och ska gå till väga vid sin tolkning och tillämpning av regler

Den ökade erosionen till följd av havsnivåhöjningen, orsakad av klimatförändringarna, som läggs på den redan förekommande erosionen kommer få stora konsekvenser. Mark kommer att försvinna där det i dagsläget finns bostäder, vägar, järnvägar, hem för djur- och växtliv, osv. Dessutom leder erosionen till att mark som idag finns tillgänglig för nybyggen i kustnära områden inte längre kommer att exist

Title – Using Lean Practices to Develop Improvement Suggestions for a Warehouse: A case study of a company in the perishables industry Author – Leon Liljeqvist Supervisor – Joakim Kembro, Division of Engineering Logistics, Faculty of Engineering – LTH, Lund University Purpose – The purpose of this thesis is to improve the turnover of goods at the most prominent locations in the warehouse's