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AimsSocial participation is an important determinant of health-related behaviours and health. Communication disorders such as stuttering may be associated with participation. Research concerning the association between stuttering and social participation among older adults is scarce. Therefore, the aim of this population-based cross-sectional study was to investigate associations between self-perc
Segregation is a pervasive social phenomenon that separates individuals across social settings. Workplaces, as key hubs of the labor market, are not only central to economic outcomes but also potential sites for cross-cutting social ties. Yet workplace segregation can exacerbate inequality and weaken social cohesion. Existing research has largely examined highly visible categories such as rac
Objective: Retroperitoneal lymph node dissection (RPLND) for testicular germ cell cancer is a complex procedure associated with postoperative complications and long-term morbidity, best performed by experienced surgeons at high-volume centers. This study evaluates surgical outcomes of RPLND in a centralized population-based cohort. Methods: This is a retrospective analysis of a prospective multice
Introduction: A recent report from the United Nations showed that aged people are increasing worldwide. Few data exist on overall survival for patients 80 years or older undergoing benign thyroid surgery. Short- and long-term survival and risk factors for death in patients undergoing thyroid surgery for benign disease were evaluated, using a nationwide, population-based quality register. Methods:
Rationale: Benzodiazepines, gabapentinoids, hypnotics, and opioids can depress respiration, alter sleep, and potentially affect outcomes in individuals treated with home mechanical ventilation (HMV) for obesity hypoventilation syndrome (OHS). Objectives: To analyze the association of benzodiazepines, gabapentinoids, hypnotics, and opioid use with hospitalization-free survival and mortality after s
Background: As a surrogate for eosinophilic activation, eosinophil-derived neurotoxin (EDN) is a potential clinical biomarker. However, EDN levels and discriminatory ability in different asthma phenotypes are unknown. We quantified serum and nasal lavage fluid (NLF) EDN levels and assessed the potential to differentiate clinically defined asthma phenotypes in an adult-representative sample. Method
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of death, with substantial residual risk persisting despite current lipid-lowering, antithrombotic, antihypertensive, weight-management, and anti-inflammatory therapies. This unmet clinical need reflects the multifactorial and heterogeneous nature of ASCVD, which is not fully captured by traditional discovery approaches. Recent adva
Factors limiting fat cell expandability remain scarcely explored, and comprehensive functional comparisons of adipose depots in humans are limited. In the present study, we collected visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) paired-samples from 22 patients with obesity undergoing elective Roux-en-Y gastric bypass surgery. Whole tissue samples were used to determine adipoc
PURPOSE: To describe a less invasive laser therapy for retinopathy of prematurity, referred to as ridge-adjacent laser treatment (RALT), and its outcome regarding the need for re-treatment.METHODS: This was a retrospective observational review of medical records of all infants treated with RALT as a primary intervention for retinopathy of prematurity between June 2016 and June 2021 at a tertiary c
Steel is a strategic material for Europe, embedded in critical sectors such as construction, transport and defence, yet responsible for approximately 5% of EU CO2 emissions. While technological pathways for low-emission steel are advancing, their large-scale deployment depends on credible demand signals capable of supporting early market formation and reducing investment uncertainty. In response,
INTRODUCTION: Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation.METHODS: We conducted an observational before-and-after study including the first non-tunnelled CVC insertion performed in adult patients with haematological diseases
Background: Older people with intellectual disabilities have complex healthcare needs, with many somatic and psychiatric co-morbidities and high healthcare utilization, including unplanned (i.e., acute) healthcare contacts. However, little is known about predictors of unplanned healthcare contacts—a possible proxy for unmet healthcare needs, particularly during the COVID-19 pandemic.Research Quest
MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β-cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β-cell compensation and progressive secretory dysfunction. Here, we review current insights into the regulation of insulin secretion, with a focus on exocytosis and the autocrine
BACKGROUND: Proximal humeral fracture (PHF) is the fourth most common nonspinal fracture in adults. The long-term clinical outcomes after nonoperative treatment for different PHF types are unclear. This study aims to evaluate the long-term clinical outcomes of a nonoperatively treated PHF across various fracture types using the Neer and Arbeitsgemeinschaft für Osteosynthesefragen (AO) classificati
