Context: Adhesion G protein-coupled receptor (GPCR)-G1 (ADGRG1) is the most abundant GPCR in human pancreatic islets, but its role in islet function is unclear. Objective: Investigate how ADGRG1 expression and activation by its ligand, collagen III, impacts β-cell function in normal and type 2 diabetic (T2D) islets. Design: Genes associated with the ADGRG1 in human islets was probed by RNA-sequenc

Vitamin A-derived retinoic acid (RA) signals are critical for the development of several organs, including the pancreas. However, the tissue-specific control of RA synthesis in organ and cell lineage development has only poorly been addressed in vivo. Here, we show that retinol dehydrogenase-10 (Rdh10), a key enzyme in embryonic RA production, has important functions in pancreas organogenesis and

Obesity is a risk factor for a plethora of severe morbidities and premature death. Most supporting evidence comes from observational studies that are prone to chance, bias and confounding. Even data on the protective effects of weight loss from randomized controlled trials will be susceptible to confounding and bias if treatment assignment cannot be masked, which is usually the case with lifestyle

Objective:: The loss of a parent to cancer is considered one of the most traumatic events a teenager can experience. Studies have shown that teenagers, from the time of diagnosis, are already extremely worried about the consequences of a parent's cancer but tend to be left to manage these concerns on their own. The present study aimed to explore young adults' advice to healthcare professionals on

BACKGROUND: The discovery that heterozygous missense mutations in the gene encoding triggering receptor expressed on myeloid cells 2 (TREM2) are risk factors for Alzheimer's disease (AD), with only the apolipoprotein E (APOE) ε4 gene allele conferring a higher risk, has led to increased interest in immune biology in the brain. TREM2 is expressed on microglia, the resident immune cells of the brain

Every year the Composition Department at Malmö Academy of Music, Lund University, takes part in several composition projects for the students to get the experience of live rehearsals and concerts with various types of ensembles. The projects have been going on since 1995 in different combinations. See below for the project status in September 2016: MALMÖ SYMPHONY ORCHESTRA 1 master student from th

Reducing the prevalence of mastitis caused by Staphylococcus aureus (S. aureus) is essential to improve animal health and reduce economic losses for farmers. The clinical outcome of acute mastitis and risk of progression to persistent mastitis can, at least to some extent, be related to genetic variants of the strain causing the infection. In the present study we have used microarrays to investiga

BACKGROUND: Life satisfaction (LS) is an overall goal in the long-term management and rehabilitation of persons with Parkinson's disease (PD). However, very little is known about LS in persons with PD and no study has examined factors associated with their LS. OBJECTIVE: To describe LS in persons with mild to moderate PD and to evaluate the association with gender, age, years since diagnosis, and

PurposeThe main purpose of this study is to investigate perceptions about and contributing activities to business-to-business (B2B) brand value by corporate managers and local stakeholders in the context of emerging markets.Design/methodology/approachThe case study examines brand strategies of a multinational company in the high-tech industry. By using NVIVO, this research analyses the brand narra

Early psychosocial adversities and maladjustment, such as childhood maltreatment and school adjustment problems, have been linked to an increased risk of aggressive antisocial behaviors. Yet, clinical studies of subjects at the highest risk of persistence in such behaviors are rare, especially during the life-changing transition years of emerging adulthood. This study describes early predictors of

As the saying goes, “a beloved child has many names”. So, too, is the case with the concept to be dealt with in this paper. Over the years various concepts have been used to denote education in a lifetime perspective, such as “education permanente”, recurrent education and lifelong learning. There are many who have disputed the correctness or appropriateness of one or the other concepts. Boudard (

Whistle-blowing can serve as a powerful mechanism helping policy-makers and other stakeholders recognize ethical misconduct and other types of wrongdoing in autonomous public agencies. This mechanism is of particular importance in major public sector reforms, such as agency mergers, when it may be difficult to secure continuity in the quality of organizational processes. Yet, we know little of wha

Something has happened in the field of Service Studies. With the introduction of what has been called Service Dominant Logic a large proportion of the established theories related to service as a phenomenon has been challenged. From previously having been defined as something different from the tangible things we buy (goods); i.e. a residual, service defined out of what service is not, the new lin

The radiation balance of urbanised catchments differs from their rural counterparts, with snowpacks experiencing either enhanced or decreased irradiance depending on snowpack location and condition. As snowmelt is largely driven by radiation inputs, changes to localised irradiance (and melt rates) have implications for urban runoff generation. Storm- and wastewater drainage systems in cold regions