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Stem cells are unique, undifferentiated cells that have the ability to both replicate themselves and develop into specialized cell types. This dual capability makes them valuable in the development of regenerative medicine. Current development in stem cell research has widened their application in cell therapy, drug discovery, reproductive cloning in animals, and cell models for various diseases.
Objective: Extremes of prepregnancy maternal BMI increase neonatal mortality and morbidity at term. They also increase the risk of extremely preterm (EP, i.e., <27 weeks' gestational age) births. However, the association between maternal BMI and outcomes for EP babies is poorly understood. Methods: We used a cross-country design, bringing together the following three population-based, prospective,
The European Union’s aim to decarbonize the building stock by 2050 requires significant reductions in the energy use for space heating and cooling. One such solution to decarbonization could be energy sharing between buildings. This paper presents the potential for energy saving and subsequent reduction in carbon emission with a low temperature district network in an energy community based in Malm
Background: Adverse skin reactions to continuous glucose monitors (CGMs) and devices for continuous subcutaneous insulin infusions (CSIIs) (“diabetes medical devices” (MDs)) are well known. However, epidemiological studies on prevalence and skin rash details are lacking. The objective of this study was to describe the prevalence and details of skin rash to diabetes MDs in adults with type 1 diabet
Low birth weight (LBW) is a risk factor for type 2 diabetes (T2D). We hypothesized that 4 weeks of carbohydrate overfeeding (COF) with +25% energy would unmask key T2D perturbations among 22 nonobese LBW men, including five with screen-detected metabolic dysfunction-associated steatotic liver disease (MASLD), compared with 21 healthy control participants with normal birth weight (NBW). Body weight
BACKGROUND: Ischemia/reperfusion injury is an unavoidable consequence of kidney transplantation, yet the characteristics of the immediate immune response after reperfusion and its impact on transplant outcomes remain poorly characterized in the clinical setting.METHODS: We conducted a cohort study including 63 kidney transplant recipients (26 living-donor, 37 deceased-donor) with an extended 4-y f
AIM: The aim of this study was to evaluate risk factors for venous thromboembolism (VTE) and deep vein thrombosis after living donor nephrectomy in a center using extensive preoperative screening and perioperative venous duplex scan.MATERIAL AND METHODS: Thrombophilia screening and pre- and postoperative ultrasonographies were performed in 130 consecutive living kidney donors (laparoscopic 105, op
Celiac disease etiopathogenesis requires genetic predisposition and exposure to gluten, yet these factors alone are not sufficient. Larger longitudinal studies are needed to determine the role of time-varying infections and gut microorganisms. The aim was to design a celiac disease case-cohort longitudinal study using The Environmental Determinants of Diabetes in the Young (TEDDY) study. By age 3-
Over the years, demand-responsive transport (DRT) and similar concepts have been implemented and tested in different environments and in different configurations. However, many of these transport services have been abandoned, for various reasons. Previous research shows that some of the most important success factors for a DRT service to sustain over the years are low-cost solutions adjusted to a
The revitalization of existing neighborhoods has been a frequent topic of public and academic debate in post–industrial times. Yet, little is known about the potential of individual, commercial real estate development projects to revitalize neighborhoods. Adaptive reuse of existing buildings, especially when combined with collaborative spaces, have been linked to positive social impacts beyond cul
Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both
Bus Rapid Transit (BRT) has predominantly been implemented in major urban areas worldwide, but interest is growing in its application within small and medium-sized cities. In these contexts, enhanced bus-based public transport is often essential for promoting more sustainable transport systems. However, limited research has explored how BRT can be adapted to smaller cities, particularly in Europe,
Insulin resistance (IR) contributes to atherogenic dyslipidemia and elevated ASCVD risk. Apolipoprotein A1 (ApoA1)-associated lipoproteins have diverse anti-atherogenic functions, but it is unclear whether IR drives adverse changes in their proteomic composition. We hypothesized that IR is associated with an atherogenic ApoA1 proteome and that insulin-sensitizing interventions would improve its co
Purpose: Direct laryngoscopy (DL) is the standard technique for endotracheal intubation. Video-assisted laryngoscopy (VL) has emerged as an alternative, particularly for difficult airway management. Nevertheless, DL and VL have not been systematically compared for simulation-based endotracheal intubation by inexperienced operators. Method: A prospective, randomized cross-over study was carried out
