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Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reportin
Carbohydrate quality might be more important than quantity to reduce type 2 diabetes (T2D) risk. Various metrics of carbohydrate quality exist; however, their associations with T2D have only been studied to a limited extent. Consequently, the aim was to investigate the association between four different pre-defined carbohydrate quality indices, with various amounts of fiber (≥1 g) and free sugar (
Eczema is a common chronic disease that affects both children and adults, and may have an adverse impact on school performance, as it is characteristically pruri-tic, and hence may lead to poor concentration and ina-dequate sleep. The aim of this study was to elucidate the relationship between eczema and self-reported difficulties keeping up with school education. The study was based on cross-sect
Adipocyte dysfunction is a hallmark of systemic insulin resistance. Insulin-responsive glucose transporter 4 (GLUT4) is downregulated in the insulin resistant state, and cellular insulin responsiveness varies depending on fat-depot origin and degree of adipose expansion. Here, we have resolved factors limiting cellular insulin responsiveness, by examining adipocyte function and traits related to g
BACKGROUND: Intracranial hemorrhage (ICH) is a potentially severe complication of endovascular thrombectomy (EVT). However, the relationship between the incidence and severity of ICH and vascular occlusion location is not well described.OBJECTIVE: To present a comprehensive analysis of subtypes of ICHs and their relationship to the occlusion site following EVT in the anterior circulation.METHODS:
The technical development of high-throughput sequencing technologies and the parallel development of targeted therapies in the last decade have enabled a transition from traditional medicine to personalized treatment and care. In this way, by using comprehensive genomic testing, more effective treatments with fewer side effects are provided to each patient—that is, precision or personalized medici
Knowledge about risks for overuse of psychoactive analgesics in patients having primary surgery for carpal tunnel syndrome (CTS) or ulnar nerve entrapment (UNE), or both, is limited. We investigated if patients with those nerve entrapment disorders have a higher risk of overuse of psychoactive analgesics (i.e., opioids and gabapentinoid drugs) before, after, and both before and after surgery than
Body-focused repetitive behavior disorders, including trichotillomania (hair-pulling disorder) and excoriation (skin picking) disorder, typically emerge in early adolescence, but little is known about the clinical characteristics and treatment outcomes of these disorders in young people, particularly in real-world clinical settings. Participants were 63 children and adolescents (51 girls; age rang
Most work implies the use of digital systems and tools, thus, digital technology plays a vital role in modern work environments. Even so, ergonomics and usability of IT systems and digital tools used at work are often weak, which causes work-related health problems including physical, visual, cognitive, and stress-related issues. We pose that one important reason for these types of issues is the l
In recent years, the need for affordable sustainable housing has increased. At the same time, there has been a gradual rising interest in compact living. With the mounting impacts of climate change, a new way of thinking is needed to develop more resilient and climate responsive ways of living that are compact, affordable, and climate-conscious. In response to this need, the idea of a ‘Z-Free Home
Stora företag i västvärlden har de senaste åren i ökad takt inkorporerat social rättvisa (jämställdhet, HBTQ+ rättigheter, rättvisa i rasfrågan) och miljörättvisa i deras marknadsföring och reklam. Modebranschen är en av de branscher som har använt sig särskilt mycket av social rättvise-symbolik. Denna avhandling fokuserar på artikulationer av miljö, genus, och ras genom en studie av hållbarhet ocThe corporatisation of social justice (gender justice, LGBTQI+ rights, racial justice) and environmental justice ideals in the last decades has grown immensely in western countries, exemplified by rainbow-clad ATM’s during Pride month or Nike using images of NFL player Kaepernick’s anti-racism protest action of taking a knee during the USA national anthem in a marketing campaign. One of the indust
Background: Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated wit
A policy entrepreneur is a distinct political actor aiming to affect change. The theoretical narrative regarding policy entrepreneurs is underpinned by their commitment to a policy solution, the multi-dimensional strategies they use to promote that solution, and a suite of attributes and skills facilitating their actions. Policy entrepreneurs reveal themselves through their attempts to transform p
