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Since 2021, the DarkLab at Lund University (LU) and the Digital Research Service at the French National Institute of Art History (INHA) have collaborated to develop state-of-the-art digital systems and tools for the management and publication of archaeological data, including information from fieldwork and artefact collections. Drawing on the combined expertise of both institutions, this partnersh

Identifying patients at risk for metastatic relapse is a critical medical need. We identified a common missense germline variant in proprotein convertase subtilisin/kexin type 9 (PCSK9) (rs562556, V474I) that is associated with reduced survival in multiple breast cancer patient cohorts. Genetic modeling of this gain-of-function single-nucleotide variant in mice revealed that it causally promotes b

High-resolution x-ray tomography is a common technique for biomedical research using synchrotron sources. With advancements in laboratory x-ray sources, an increasing number of experiments can be performed in the lab. In this paper, the design, implementation, and verification of a laboratory setup for x-ray nano-computed tomography is presented using a nano-focus x-ray source and high geometric m

Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on P

Extruded mortar joints, resulting from suboptimal workmanship in bricklaying, bridge air gaps within cavity external walls. This phenomenon establishes a connection between brick masonry claddings and adjacent layers (such as insulation or weather-resistive barriers), inadvertently intensifying water penetration due to wind-driven rain (WDR) loads. This study utilises a probabilistic analysis in c

Complex metabolic diseases due to overnutrition such as obesity, type 2 diabetes, and fatty liver disease are a major burden on the healthcare system worldwide. Current research primarily focuses on disease endpoints and trying to understand underlying mechanisms at relatively late stages of the diseases, when irreversible damage is already done. However, complex interactions between physiological

While hybridisation in vascular plants has received considerable attention, hybridisation in bryophytes is still relatively understudied. Here we investigate hybridisation between two species from the moss genus Dicranum Hedw. Dicranum scoparium Hedw. and D. bonjeanii De Not. are two moss species of the D. scoparium species complex with partially overlapping morphology and habitat ranges. This stu

Type 2 diabetes is associated with cardiovascular disease, possibly due to impaired vascular fibrous repair. Yet, the mechanisms are elusive. Here, we investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque extracellular matrix by combining multi-omics from the human Carotid Plaque Imaging Project cohort and functional studies. Plaques from type 2 diabetes

This paper studies family commitment among fast-track professionals and explores how continued childbearing and union stability vary among high-achieving men and women. The focus is on three particular fast-track professional groups (e.g., lawyers, medical doctors and Ph.D.s), that face quite different career structures and work environments that may affect family life. The determinants of having

Previous research has consistently found demographic responses to grain price fluctuations in preindustrial Europe, both at macro and micro level. Grain prices serve as a summary measure of the workings of the preindustrial economy, reflecting not only local harvest conditions but trade patterns and market integration. All over preindustrial Europe the manorial estate was an important institution

In the effort to separate pedestrian and bicycle traffic from motorised traffic the solution often is to let the pedestrians and bicyclists share space. However, combined pedestrian and bicycle paths lead to problems for both pedestrians and bicyclists; for pedestrians it is a security and safety problem and for bicyclists a mobility problem. Seniors and visually impaired pedestrians are especiall

The almost complete focus on the aggregate level in previous research on demographic, socioeconomic and cultural determinants of the fertility transition means that we to a large extent not only lack knowledge about the specific mechanisms of the decline, but also its socioeconomic patterns. In this paper we explore socioeconomic fertility differentials in an industrializing community of southern

The myriad of interpersonal relationships in tourism, between tourists, between tourists and locals, and between tourists and the service providers, are essential, generic components of the tourist experience. However, interpersonal relationships are emerging as a commercial value in the tourism industry as well, expressed for example in rural commercial home type of businesses, and in wellness-or

Varying degrees of collaboration and consultation in the area of child and family welfare in the public sector has grown rapidly since the 1980s, especially concerning children at risk. Collaboration is understood to provide a more holistic view of the individual's needs, lead to better care and treatment as well as increase knowledge in general. Collaboration in that sense constitute a flexible a