Search results

This study assessed whether methods for capturing the pedestrian experience of outdoor lighting, previously evaluated in a full‐scale laboratory, were applicable in a real‐world setting. It applied an approach capturing the human response to outdoor lighting in a systematic way, by assessing perception, evaluation and behaviour in the lit environment. The study involved 81 participants from two ag

C-terminal α-amidation is the final and essential step in the biosynthesis of several peptide hormones. Peptidylglycine α-amidating monooxygenase (PAM) is the only known enzyme to catalyse this reaction. PAM amidating activity (AMA) is known to be present in human circulation, but its physiological role and significance as a clinical biomarker remains unclear. We developed a PAM-specific amidation

AIM Enterococci cause 2-11% of all prosthetic joint infections (PJI) and are generally considered difficult to treat. However, study-results are not consistent. In this study we present a population-based case series of 55 cases with enterococcal PJI, investigating treatment and outcome, as well as describing the affected patient population regarding demography and co-morbidities. METHODS We ident

Objective: Smooth muscle cells contribute significantly to lipid-laden foam cells in atherosclerotic plaques. However, the underlying mechanisms transforming smooth muscle cells into foam cells are poorly understood. The purpose of this study was to gain insight into the molecular mechanisms regulating smooth muscle foam cell formation. Approach and results: Using human coronary artery smooth musc

Insulin secretion is impaired with increasing age. In this study, we aimed to determine whether aging induces specific transcriptional changes in human islets. Laser capture microdissection was used to extract pancreatic islet tissue from 37 deceased organ donors aged 1–81 years. The transcriptomes of the extracted islets were analysed using Ion AmpliSeq sequencing. 346 genes that co-vary signific

The United Nation’s Sustainable Development Goals state that education is both an end and a means for achieving sustainable development. Currently, education for sustainability focuses on (assessing and addressing) the external world of ecosystems, wider socio-economic structures, technology, and governance dynamics. A major shortcoming of such approaches is the neglect of inner dimensions and cap

The term ´lifestyle enterprise´ is often used to describe enterprising in small enterprises, and particularly those small enterprises involved in tourism. Although this lifestyle enterprising phenomenon has been the subject of scholarly investigations since at least the late 1980s, conceptual and theoretical development remains lacking. Typically conceived in objectivist terms as a form of entrepr

Management of asymptomatic carotid disease continues to challenge medical practice and present evidence is often conflicting. Stroke is a significant burden in Public Health and 11% to 15% appear as first neurologic event associated with asymptomatic carotid stenosis. Randomized trials provided support for Guidelines and Recommendations to intervene on asymptomatic stenosis, but at a known cost of

Omräkning av barns (≥2 år) kreatininvärden till motsvarande värden vid 18 års ålder och applicerade i Lund–Malmö-formeln för vuxna ledde till avsevärt förbättrad skattning av GFR bland barn vid uppmätt GFR <75, bibehållen noggrannhet ≥75 ml/min/1,73m2 och likvärdig med pediatriska formler.Lund–Malmö-formeln kan användas under hela livet ≥2 år utan plötsliga artificiella förändringar i skattad GFR

The starting point of this paper is to document considerable cross-country variation in the “labor wedge”, a common measure of labor market frictions. Its variation is theoretically isomorphic to differences in a preference-for-leisure parameter. The paper proceeds to investigate what might explain the variation. It presents three separate empirical exercises supportive of the view that, to a subs

Avoiding absorption in the upper gastrointestinal tract is one of the challengesconsidering targeted colon delivery but not much attention has been paid tomicrobial activity of vector material in saliva and small intestine. The aim of thepresent study was to develop an in vitro prototype model for evaluatingdigestion of encapsulation material by oral bacterial species based on readilyobtainable sa

In most mammals, the cell cycle kinase; cyclin-dependent kinase 2 (CDK2) is expressed as two major isoforms due to alternative splicing. The shorter CDK2 isoform: CDK2S, is expressed constitutively during the cell cycle and can be detected in several tissues. In contrast, the longer isoform: CDK2L, shows preferential expression in meiotically dividing cells and upon S-phase entry in the mitotic cy

Brown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency stimulates BAT in mice, thus contributing to a decrease in fat accumulation. Local in vivo AAV-mediated RAP250 silencing in BAT reduces body weight and fat mass and enhances glucose oxidation, thereby indicatin

In an increasingly globalized and digitized economy, goodwill—the intangible value linked to a company’s reputation, customer trust, and market position—is a central asset for businesses. However, this value is at risk of being rapidly threatened by unfair use and free-riding on reputation, especially through the growing trade of counterfeit goods online. This thesis examines the legal possibiliti