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The immune system is integral to cardiovascular health and disease. Targeting inflammation ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of cardiovascular disease, is conceptualized as lipid-driven inflammation in which macrophages play a nonredundant role. However, evidence emerging so far from single-cell atlases suggests a dichotomy between lipid-associa

The art of living and the art of eating: Professor Linnaeus recommends. By Gunnar Broberg. As professor of medicine, Linnaeus taught dietetics. He followed the pattern outlined by Galen and Regimen salernitatis, adding an extensive material originating from general cultural history and his own experience.Early in his life he wrote Diaeta naturalis, a collection of rules focusing the blessings of n

Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supe

Despite their detrimental circumstances, the number of refugee-owned businesses is on the rise—a situation referred to as “the paradox of refugee entrepreneurship.” However, a key question is how refugees, having undergone extreme life disruption due to war, conflict, and forced displacement, fare as entrepreneurs in their host country. Extant studies do not address this question, as they primaril

Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandial changes and explored their links with chronic and acute inflammatory responses in healthy individuals and

When interpreting a natural language argument that generalizes over a contextually relevant category, audiences are likely to activate the category prototype and transfer its characteristics onto category instances. A generalized argument can thus appear more (respectively less) persuasive than one mentioning a specific category instance, provided the argument’s claim is more (less) warranted for

Co-housing is often lauded as an alternative housing form offering a more socially, ecologically and economically sustainable way of living. This book takes its departure in the need for a critical exploration of co-housing in the context of sustainable urban development, beyond the normative approach that often characterizes co-housing research. Based on a four-year research project involving in-

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estim

Previous research has shown integrated planning to be important for achieving aims concerning more environmentally friendly transport operations, but less good at explaining prerequisites of implementation. This paper analyses how management and working practises in local authorities, here understood as steering cultures, affect implementation of integrated land-use and public transport planning a

In post-industrialist societies, similar high standards of living are becoming not only desired but also expected the world over. Globalising processes ensure that every material desire is within the reach of ordinary citizens, and then flame these desires in order to sustain continuous growth narratives. But are increasingly resource-intensive lifestyles sustainable, or even desirable? This artic

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent