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The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified

Naturally occurring human genetic variants that are predicted to inactivate protein-coding genes provide an in vivo model of human gene inactivation that complements knockout studies in cells and model organisms. Here we report three key findings regarding the assessment of candidate drug targets using human loss-of-function variants. First, even essential genes, in which loss-of-function variants

Public procurement is widely used in order to incorporate competition into public services. Competition in procurement often leads to efficiency but the process can also raise some problems. While providing the procurement documents you do not know who will be your upcoming partner. Another aspect is how flexibility can be managed in contract design while maintaining a high service quality. The ai

This article examines the role of national parliaments in policy processes related to the realization of the 2030 Agenda for sustainable development, adopted in the UN General Assembly in 2015. We outline three main roles of parliaments in the case of national policy-making based on intergovernmental agreements: legislative and policy approval, citizen representation, and accountability. The cases

Large scale infrastructure developments means balancing of partly conflicting interests of economic growth, social cohesion, environmental impact etc. How this balancing is done when the project hits the local context is depending on the legislative framework, for instance through building permits environmental assessment. Still, there can be a big difference between the intentions of the law, and

Competing Institutional Logics in Diaconal Work “Institutional logics” is a concept within the context of institutional theory. Institutions can be defined as patterns of activity rooted in material practices and symbolic systems. These institutional orders are all shaped by the history and each of them has a central logic that guides its organizing principles. The institutional logic provides

Various policy instruments and policy reforms are being implemented to encourage Green Growth and Green Economy. However, comprehensive ex-post evaluation policy methods have yet to be developed. The emerging literature shows that there is substantial ambiguity and discrepancy about how to measure the performance of policy instruments driving a Green Economy in general and, in our case, a Green En

The aim of the thesis is to develop a model, based on well known physical and empirical formulas, to simulate the heat load on a rink of artificially frozen ice. A comparison of the results from this model and the results from other methods to determine heat load of the rink is made. The model calculates the heat load from convection, long wave radiation from the air temperature and from the sky t

Today, due to the fast development of Internet Protocol TV (IPTV), which is the combination of IP technology and two-way broadband networks, the telecom industry is undergoing fundamental changes. Network operators and service providers around the world are making significant investments in order to deliver digital video content to their subscribers. Video puts very high demands on the network and

C-terminal α-amidation is the final and essential step in the biosynthesis of several peptide hormones. Peptidylglycine α-amidating monooxygenase (PAM) is the only known enzyme to catalyse this reaction. PAM amidating activity (AMA) is known to be present in human circulation, but its physiological role and significance as a clinical biomarker remains unclear. We developed a PAM-specific amidation